Thrombophilic Risk Factors in Different Types of Retinal Vein Occlusion in Tunisian Patients

Mrad, Meriem; Fekih-Mrissa, Najiba; Wathek, Cheima; Rannen, R.; Gabsi, S.; Gritli, Nasreddine

doi:10.1016/j.jstrokecerebrovasdis.2013.12.048

Cited by 8 publications

(14 citation statements)

References 33 publications

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“…Risse et al [ 55 ] in a study of 51 patients with BRVO on age-, gender-, and C-reactive protein-adjusted logistic regression analysis did not fi nd a signifi cant additive effect of elevated factor VIII activity on the risk of developing BRVO. Mrad et al [ 56 ] in 68 patients with BRVO found no statistically signifi cant differences in the frequencies of the prothrombin G20210A polymorphism between the BRVO group and healthy controls. Sartori et al [ 57 ] reported that cardiovascular but not thrombophilic risk factors seem to be infl uenced by age in retinal vein occlusion patients.…”

Section: Hematologic Abnormalitiesmentioning

confidence: 90%

Branch Retinal Vein Occlusion

Hayreh

2014

Ocular Vascular Occlusive Disorders

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Section: Hematologic Abnormalitiesmentioning

confidence: 90%

Branch Retinal Vein Occlusion

Hayreh

2014

Ocular Vascular Occlusive Disorders

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“…The G/A genotype of Factor V G1691A was previously associated with an increased risk of RVO in French [ 14 ] and Tunisian [ 43 ] populations. However, no differences in the frequency of the Factor V G1691A polymorphism between RVO cases and controls were reported in studies of Turkish populations [ 22 , 32 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Factor VG1691A is associated with an increased risk of retinal vein occlusion: a meta-analysis

Zou

Zhang

et al. 2017

Oncotarget

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We performed a meta-analysis to investigate the association between the Factor V G1691A polymorphism and the risk of retinal vein occlusion (RVO). This analysis included 37 studies involving 2,510 cases and 3,466 controls. Factor V G1691A was associated with an increased risk of RVO in the allele, heterozygote, dominant, and carrier models (PA < 0.001, odds ratios >1), but not the homozygote or recessive models (PA > 0.05). Similar results were observed in a meta-analysis of central retinal vein occlusion (CRVO) and when comparing Caucasian subgroups to population-based controls. These data demonstrate that the G/A genotype of Factor V G1691A is associated with an increased risk of RVO/CRVO in a Caucasian population.

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“…APLA was also reported as an important biomarker for thrombophilia, thrombophilia and vascular risk factors. APLA was potentially important in the incidence of RVO [ 28 , 29 ]. A previous meta-analysis reported that congenital thrombophilic diseases were associated with the risk of RVO [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Antiphospholipid Antibody and Risk of Retinal Vein Occlusion: A Systematic Review and Meta-Analysis

Zhu

et al. 2015

PLoS ONE

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BackgroundRetinal vein occlusion (RVO) is a common retinal vascular disease and it is one of the most frequently reported causes of visual damage and blindness in the elderly. The current study investigated the potential association between antiphospholipid antibodies (APLA) and RVO risk by conducting a meta-analysis of case–control studies.MethodsA systematic literature search of Pubmed and Embase databases was conducted in August 1st, 2014. Odds ratios (ORs) were used to evaluate the associations between APLA and the incidence of RVO. A random-effects model was obtained for the quantitative synthesis.ResultsA total of 11 studies were included in this meta-analysis. A meta-analysis of all studies assessing the risk of RVO revealed that APLA was associated with a statistically increased risk of RVO incidence (OR = 5.18, 95% CI = [3.37, 7.95]). The association between anticardiolipin antibodies (ACA) and the risk of RVO was significant (n =8, OR = 4.59, 95% CI = [2.75, 7.66]). However, the association between lupus anticoagulants (LA) and risk of RVO was non-significant (n = 5, OR = 3.90, 95% CI = [0.99, 15.37]). No significant publication bias was found in the 11 selected studies.ConclusionAPLA was significantly associated with the risk of RVO. Advanced analyses showed that ACA rather than LA affected the risk of RVO. Additional well-designed and well-conducted epidemiological studies are required to further our understanding of the relationship between APLA and RVO risk.

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Thrombophilic Risk Factors in Different Types of Retinal Vein Occlusion in Tunisian Patients

Cited by 8 publications

References 33 publications

Branch Retinal Vein Occlusion

Branch Retinal Vein Occlusion

Factor VG1691A is associated with an increased risk of retinal vein occlusion: a meta-analysis

Antiphospholipid Antibody and Risk of Retinal Vein Occlusion: A Systematic Review and Meta-Analysis

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