Thrombose veineuse cérébrale de l’enfant: à propos d’une série de 12 cas

Baddouh, Naima; Elbakri, Safaa; Draïss, Ghizlane; Mouaffak, Y.; Rada, Noureddine; Younous, S.; Bouskraoui, M.

doi:10.11604/pamj.2019.32.22.17656

Cited by 4 publications

(1 citation statement)

References 23 publications

(35 reference statements)

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“…Dehydration and infection increase the risk of venous thrombosis, particularly in children [ 28 , 29 ]. It is important to ensure patients with CBS deficiency are well-hydrated at all times, especially when sick and during anesthesia and surgery.…”

Section: Discussionmentioning

confidence: 99%

Recurrent dislocation of binocular crystal lenses in a patient with cystathionine beta-synthase deficiency

et al. 2021

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Background Ectopia lentis is the common ocular manifestation of homocystinuria resulting from cystathionine beta-synthase (CBS) deficiency which has a high risk of thromboembolic complications. Case presentation The present study reports the case of a teenager with recurrent lens dislocation and glaucoma. He was diagnosed with CBS deficiency according to a high level of serum homocysteine and compound heterozygous mutations at two different positions on the CBS gene. Antiglaucoma eyedrops and a mydriatic successfully controlled the intraocular pressure, while oral pyridoxine and betaine uptake lowered the serum homocysteine level effectively. Conclusions Children with CBS deficiency may suffer from ectopia lentis, glaucoma and/or amblyopia. We firstly discovered a new mutation of CBS c. 697 T > G which had not been reported before. The patient was pyridoxine responsive and well controlled by medicine.

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Section: Discussionmentioning

confidence: 99%

Recurrent dislocation of binocular crystal lenses in a patient with cystathionine beta-synthase deficiency

et al. 2021

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Fatal cerebral sinus thrombosis associated with diabetic ketoacidosis in a child

Bellali,

Zaara,

Belhaj

et al. 2023

Forensic Sci Med Pathol

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Cerebral Venous Thrombosis in Children: About 3 Cases

Menjel,

Benmoussa,

Harim

et al. 2024

AJP

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The cerebral venous system is an unusual site for thrombosis. It is a rare pathology in children, with a considerable risk of morbidity and mortality in the absence of specific treatment. The incidence has increased over the last few decades due to improvements in neuroradiological techniques. Clinical features range from seizures, headache and respiratory distress to threatening focal neurological deficits and comatose state. The risk factors are age-dependent, frequently multiple and different from those reported in adults. Infections are the most common predisposing factor both in neonates and older children, followed by hypercoagulable/hematological states, dehydration and various other conditions. In majority of cases, it results from combination of prothombotic risk factors with or without underlying clinical condition. The prognosis is favorable in most cases if the diagnosis is made quickly and treatment is initiated promptly, although acute complications or chronic disability still occur in a quarter of patients. The mainstay of treatment is anticoagulation, which is needed to stop the clot spreading and recanalize it. Endovascular procedures are reserved for patients with a particularly severe presentation or rapidly developing neurological symptoms despite appropriate anticoagulation, although data from clinical trials is lacking. The aim of this work is to study the clinical, etiological, therapeutic and evolutionary characteristics of cerebral venous thrombosis (CVT) in the pediatric population.

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Thrombose veineuse cérébrale de l’enfant: à propos d’une série de 12 cas

Cited by 4 publications

References 23 publications

Recurrent dislocation of binocular crystal lenses in a patient with cystathionine beta-synthase deficiency

Recurrent dislocation of binocular crystal lenses in a patient with cystathionine beta-synthase deficiency

Fatal cerebral sinus thrombosis associated with diabetic ketoacidosis in a child

Cerebral Venous Thrombosis in Children: About 3 Cases

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