Thrombospondin-1 and CD47 regulation of cardiac, pulmonary and vascular responses in health and disease

Rogers, Natasha M.; Sharifi‐Sanjani, Maryam; Csányi, Gábor; Pagano, Patrick J.; Isenberg, Jeffrey S.

doi:10.1016/j.matbio.2014.01.002

“…5, one can also notice thrombospondin 1 (THBS1), sphingosine-1-phosphate receptor 1 (S1PR1, endothelial differentiation gene 1), and collagens I and V, which seem to be significantly involved in the pathogenesis of early graft restenosis. THBS1 and S1PR1 are VEGFs-dependent proteins [29, 31]. They affect ECs in an opposite manner.…”

Section: Discussionmentioning

confidence: 99%

Vascular restenosis in coronary artery bypass grafting might be associated with VEGF-C/VEGFR-3 signaling pathway

Podemska-Jedrzejczak

¹

,

Malińska

²

,

Sujka-Kordowska

³

et al. 2018

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The vascular endothelial growth factor (VEGF) family of peptides and caveolins (CAVs) are reported to contribute, in early graft failure in patients, a coronary artery bypass grafting (CABG). To investigate the possible association of ultimate luminal occlusion to VEGFs and CAVs expression, a functional analysis (based on the molecular biology, bioinformatics, histology, and clinical studies) was performed. Twenty-four hundred and sixty-eight CABG patients diagnosed with multivessel stable coronary artery disease (CAD) were enrolled into prospective study and assigned to two subgroups: double- and triple-vessel CAD subjects. Distal parts of all the harvested saphenous vein (SV) and internal thoracic artery (ITA) segments were used for further tests. ITA graft failure did not differ between double-vessel and triple-vessel CAD patients. The number of SV occlusions was significantly higher in triple-vessel CAD subjects. The microarray analysis performed on SV and ITA samples obtained exclusively from triple-vessel CAD patients who developed early graft occlusion revealed 383 genes with increased and 301 genes with decreased expression in ITA samples as compared to SV grafts. This was followed by functional analysis of ‘blood vessel development’ group of genes. Average VEGF-C expression in ITA grafts was higher than in corresponding SV grafts; FLT4 expression was significantly higher in SV than in ITA transplants. VEGFR-3 and CAV3 expression demonstrated immunohistochemically in SMCs of the tunica media of SV grafts predicted their early restenosis in triple-vessel CAD patients. CAV2 protein expression in SMCs of ITA grafts indicated the risk of early graft failure both in double-vessel and triple-vessel CAD subjects.

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“…Even from the time of conception, TSP-1 may affect inhibition of vascular vasodilation and apoptosis of glomerular membrane. 6,7,9,15 A limitation of this study was that the blood pressure measurements were performed on only one occasion. A 24-hour ambulatory measurement of blood pressure would be more accurate.…”

Section: Discussionmentioning

confidence: 99%

Thrombospondin-1 and blood pressure in 7-8-year-old children born low birth weight and small for gestational age

Malonda¹,

Umboh²,

Gunawan³

2018

PI

0

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Background Thrombospondin-1 (TSP-1) is associated with endothelial damage, glomerular impairment, and hypertension. Low birth weight (LBW) and small for gestational age (SGA) children have higher risk of morbidity and mortality. Objective To assess for a possible association between TSP-1 level and blood pressure in children who were born low birth weight and small for gestational age. Methods We conducted a cross-sectional study from March to May 2015. Inclusion criteria were children who were born LBW and SGA in 2007-2008 at Prof. Dr. R. D. Kandou General Hospital, resided in Manado, North Sulawesi, had complete medical records, and whose parents consented to their participation. Exclusion criteria were children who were in puberty, obese, had renal disease, taking medications that affect blood pressure, or who were admitted to the hospital in the 2 weeks prior to enrollment. Data were analyzed using regression and simple correlation tests to assess for associations between TSP-1 and birth weight, as well as TSP-1 and blood pressure. Results Subjects' mean TSP-1 level was 257.95 ng/dL. There was a strong negative correlation between TSP-1 and birth weight (r=-0.784; P<0.0001). In addition, there were strong positive correlations between TSP-1 level and systolic blood pressure (r=0.718; P<0.0001) as well as TSP-1 and diastolic blood pressure (r=0.670; P<0.0001). Conclusion Higher TSP-1 is associated with higher systolic and diastolic blood pressure in 7 to 8-year-old children who were LBW and SGA at birth. Also, TSP-1 and birth weight have a strong negative correlation. [Paediatr Indones. 2017;57:269-73; doi: http://dx

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“…Increased TSP-1 can inhibit NO, that in turn causes vasoconstriction, significantly increased glomerulosclerosis, glomerular matrix accumulation, podocyte injury, renal infiltration with inflammatory cells, and altered renal function parameters. [10][11][12][13][14][15] Nevertheless, a comparison between human and animal models of TSP-1 levels and blood pressure should be viewed cautiously since TSP-1 levels and blood pressure in animal models may differ from human models.…”

Section: Discussionmentioning

confidence: 99%

Thrombospondin-1 and blood pressure in 7-8-year-old children born low birth weight and small for gestational age

Malonda

¹

,

Umboh

²

,

Gunawan

³

2018

PI

0

View full text Add to dashboard Cite

Background Thrombospondin-1 (TSP-1) is associated with endothelial damage, glomerular impairment, and hypertension. Low birth weight (LBW) and small for gestational age (SGA) children have higher risk of morbidity and mortality. Objective To assess for a possible association between TSP-1 level and blood pressure in children who were born low birth weight and small for gestational age. Methods We conducted a cross-sectional study from March to May 2015. Inclusion criteria were children who were born LBW and SGA in 2007-2008 at Prof. Dr. R. D. Kandou General Hospital, resided in Manado, North Sulawesi, had complete medical records, and whose parents consented to their participation. Exclusion criteria were children who were in puberty, obese, had renal disease, taking medications that affect blood pressure, or who were admitted to the hospital in the 2 weeks prior to enrollment. Data were analyzed using regression and simple correlation tests to assess for associations between TSP-1 and birth weight, as well as TSP-1 and blood pressure. Results Subjects' mean TSP-1 level was 257.95 ng/dL. There was a strong negative correlation between TSP-1 and birth weight (r=-0.784; P<0.0001). In addition, there were strong positive correlations between TSP-1 level and systolic blood pressure (r=0.718; P<0.0001) as well as TSP-1 and diastolic blood pressure (r=0.670; P<0.0001). Conclusion Higher TSP-1 is associated with higher systolic and diastolic blood pressure in 7 to 8-year-old children who were LBW and SGA at birth. Also, TSP-1 and birth weight have a strong negative correlation. [Paediatr Indones. 2017;57:269-73; doi: http://dx

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Thrombospondin-1 and CD47 regulation of cardiac, pulmonary and vascular responses in health and disease

Cited by 81 publications

References 139 publications

Vascular restenosis in coronary artery bypass grafting might be associated with VEGF-C/VEGFR-3 signaling pathway

Vascular restenosis in coronary artery bypass grafting might be associated with VEGF-C/VEGFR-3 signaling pathway

Thrombospondin-1 and blood pressure in 7-8-year-old children born low birth weight and small for gestational age

Thrombospondin-1 and blood pressure in 7-8-year-old children born low birth weight and small for gestational age

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