Thymoquinone protects end organs from abdominal aorta ischemia/ reperfusion injury in a rat model

Aydın, Mehmet Salih; Koçarslan, Aydemir; Koçarslan, Sezen; Küçük, Ahmet; Eser, İrfan; Sezen, Hatice; Büyükfırat, Evren; Hazar, Abdüssemet

doi:10.5935/1678-9741.20140066

Cited by 18 publications

(24 citation statements)

References 35 publications

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“…In the present study, we have observed that TQ could protect the liver from OLZ-induced liver injury. We measured TAS, TOS, and OSI levels at the same time to evaluate the oxidative stress status more accurately, and found that serum TAS levels increased and TOS/OSI levels prominently decreased with TQ treatment as in the previous studies (44). Likewise, OLZ administration resulted in a decrease in the liver TAS level and have also reported a decline in TAS after OLZ exposure (43).…”

Section: Discussionmentioning

confidence: 80%

The protective effect of thymoquinone over olanzapine-induced side effects in liver, and metabolic side effects

Bilğiç¹,

Korkmaz²,

Azırak³

et al. 2018

BLL

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OBJECTIVES: The aim of the study was to investigate the possible protective qualities of thymoquinone (TQ) against the side-effects of olanzapine (OLZ) in an experimental model in rat liver with histologic and biochemical assessments. METHODS: Experimental procedures were performed on 35 female Sprague Dawley rats. Rats were randomly divided into fi ve groups as: group 1: control; group 2: OLZ; group 3: OLZ+TQ-1; group 4: OLZ+TQ-2; and group 5: OLZ+TQ-3. RESULTS: The results showed that a 2-week administration of OLZ (4 mg/kg, once a day for the fi rst week, 8 mg/kg once a day for the second week, p.o.) and treatment with TQ (25, 50, 100 mg/kg, once daily, p.o.) signifi cantly reduced weight gain induced by OLZ. In addition, TQ increased the total antioxidant status (TAS), high-density lipoprotein cholesterol (HDL), insulin levels and decreased serum oxidative stress index (OSI), total oxidant status (TOS), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transpeptidase (GGT), low density lipoprotein cholesterol (LDL), glucose, triglycerides (TG) and total cholesterol (CH) levels signifi cantly (p < 0.05). CONCLUSION: This study revealed that treatment with TQ might protect liver tissue against the side-effects of OLZ. TQ could be an effective course of therapy to enhance therapeutic effi cacy (Tab. 4, Fig. 4, Ref. 47). Text in PDF www.elis.sk.

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Section: Discussionmentioning

confidence: 80%

The protective effect of thymoquinone over olanzapine-induced side effects in liver, and metabolic side effects

Bilğiç¹,

Korkmaz²,

Azırak³

et al. 2018

BLL

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“…Antioxidant supplementations of Thymoquinone in Nigella sativa extract is beneficial in increasing natural antioxidants of the body, so that the expression of oxidative stress can be suppressed and skeletal healing process can be held without hindrance. [22][23][24] Continual data which were used as parameters of study is osteoblast amount, calculated from pathology anatomical samples and observed with microscope. Number of osteoblasts in rat samples with fracturing process of tibial bones exhibit more abundant number of cells in groups with administration of Nigella sativa extract compared to the amount of cells in control groups (groups with Thymoquinone administration =16.625±3.074 , control groups =4.688±2.024).…”

Section: Discussionmentioning

confidence: 99%

“…Several other studies about osteoporosis also supports the opinion of increasing ROS resulting in bone structural destruction, which is caused by the increase of osteoclast activities and disturbance to osteoblasts' functions, which in turn, reduce the number of osteoblasts from collagen synthesis. 17,20,24…”

Section: Discussionmentioning

confidence: 99%

Effect of thymoquinone: the extract of nigella sativa in accelerating soft callus formation in fracture

et al. 2019

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Background: Excessive oxidative stress on fracture case can inhibit fracture healing and decrease time of bone healing. Thymoquinone, an active substance of Nigella sativa, the so-called black cumin in common, is a potent antioxidant and have been studied as an antiosteoporotic agent. Thymoquinone is expected to be the adjuvant alternative that enhance the recovery process of fracture cases by reducing oxidative stress and promotes osteoblast proliferation on callus formation.Methods: Among 32 male mice Wistar Strain divided into 2 groups, conducted tibia fracture and casted. Group 1 was the control group without supplementation of Nigella sativa while black-cummin extract were given in group 2 orally at a dose of 800 mg/kg for 14 days. On the 14th day, group 1 and 2 were sacrificed, each bone tissue was taken to measure the levels of MDA by utilizing TBARS method and calculate the number of osteoblasts under the microscope. Data analysis were done using independent t-test.Results: There are both decreased MDA levels and increased number of osteoblasts that are histologically significant to the groups administered by Nigella sativa extract containing Thymoquinone compared to the control groups (p <0.05) on day 14.Conclusions: The administration of Thymoquinone from the extract of Nigella sativa reduced oxidative stress in fractures as well as increase the number of the osteoblast and its differentiation in callus formation.

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“…The serum MDA and NO levels significantly decreased in both cases compared with the active controls (25). Intraperitoneally administered thymoquinone, which is an active component of NS, was found to be efficient in decreasing the oxidative stress in an aorta ischemia and reperfusion model (26). Hosseinzadeh et al (6) reported that thymoquinone and NS had inhibitory effects against the lipid peroxidation process in cerebral ischemia and reperfusion injury in rats.…”

Section: CDmentioning

confidence: 99%

Effects of Nigella sativa and Hypericum perforatum on wound healing

Han¹,

Durmuş²,

Sağliyan³

et al. 2017

Turk J Vet Anim Sci

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IntroductionSkin wounds have long healing processes, and therefore they decrease the life quality of patients. The healing of wounds in a short time without any infections or scars is the desired outcome. In recent years, there have been many studies conducted on alternative treatment methods for wound healing (1-4). The studies related to wound healing aim to achieve wound healing without scar formation as well as accelerating the wound healing (4). However, studies are still ongoing to achieve optimal wound healing.From ancient times, herbal drugs have been used to treat wounds, and in many cultures their uses continue in traditional medicine. Historically, all medicinal preparations were derived from plants. Today, a significant number of drugs are developed from plants that are active against a number of diseases (5).Nigella sativa (NS) extract and its oil have antineoplastic, antibacterial, antifungal, anthelmintic, antidiabetic, and antioxidant effects, and they stimulate the immune system. These effects stem from the active compounds in the contents of NS. There are many active compounds in NS such as thymoquinone, dithymoquinone, thymol, carvacrol (volatile acids), nigellicine, nigellimine-N-oxide, nigellidine (alkaloids), and α-hedrin (triterpene) (6-8). It has been suggested that thymoquinone acts as an antioxidant and prevents membrane lipid peroxidation in tissues (9).Hypericum perforatum (HP) is used in various ways in wound healing. It is reported in the literature to have antispasmodic, sedative, antiseptic, and antidepressive effects as well as wound-healing effects (10,11). In addition, it is known to be effective against bacteria, viruses, inflammation, and pain (11,12).Today, traditional medicine is commonly used in wound healing. The aim of this study was to compare the effects of NS and HP in the form of an oil cream in concentration of 50% on wound healing in terms of clinical, biochemical, and histological aspects. Materials and methods ChemicalsNS, HP oil cream, and placebo cream were used. To prepare NS and HP oil creams, NS oil (Hel-Kim, 50 mL, Mersin, Turkey) and HP oil (Aksu Vital, 20 mL, İstanbul, Turkey) were separately mixed with equal amount of placebo cream.

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Thymoquinone protects end organs from abdominal aorta ischemia/ reperfusion injury in a rat model

Cited by 18 publications

References 35 publications

The protective effect of thymoquinone over olanzapine-induced side effects in liver, and metabolic side effects

The protective effect of thymoquinone over olanzapine-induced side effects in liver, and metabolic side effects

Effect of thymoquinone: the extract of nigella sativa in accelerating soft callus formation in fracture

Effects of Nigella sativa and Hypericum perforatum on wound healing

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