The review which follows is intended to cover those parts of the literature on internal secretions of the past two years which have seemed to the writer to be especially important or interesting. It was found impossible to master the entire literature that has sprung up about this fruitful subject, much less to include it in its entirety in a review, so that some important work may receive no mention. Cer¬ tain organs known to have an internal secretion, the genital glands and pancreas, and others thought by some to possess an internal secretory function, such as the kidney, have been purposely omitted from consideration for lack of time and space for adequate treatment. On the other hand, the pineal and carotid glands, which have been much exploited recently, have been discussed in some detail, although no certainty exists that they are organs of internal secretion. Pende's "new organ of internal secretion" has been included. 1. Thomas, E.: Beitr. z. path. Anat. u. z. allg. Path., L, 283; cited by Pappenheimer.