Thyrocalcitonin: Stimulation of Secretion by Pentagastrin

Cooper, Cary W.; Schwesinger, Wayne H.; Mahgoub, Ahmed; Ontjes, David A.

doi:10.1126/science.172.3989.1238

Cited by 129 publications

(42 citation statements)

References 10 publications

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“…Thirty years ago, it was shown for the first time that both hormones induce calcitonin secretion (20,21). The physiological and pathophysiological relevance of these early findings has been discussed controversially (22,23).…”

Section: Immunohistochemistrymentioning

confidence: 99%

Expression of the cholecystokinin 2-receptor in normal human thyroid gland and medullary thyroid carcinoma

Bläker

Weerth

Tometten

et al. 2002

European Journal of Endocrinology

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Objective: The cholecystokinin 2 -receptor (CCK 2 R) promotes secretion and cell growth induced by its ligands cholecystokinin (CCK) and gastrin. The receptor has recently been shown to be expressed in human medullary thyroid carcinomas (MTCs). The objective of this study was to analyze CCK 2 R expression in MTC samples of different tumor stages as well as in non-malignant thyroid tissues. Design and Methods: Using RT-PCR we investigated 19 MTC samples and TT-cells (a human MTC cell line), as well as samples of normal thyroid. In addition, we performed immunohistochemistry using calcitonin-and CCK 2 R-specific antibodies on MTCs and samples of C-cell hyperplasia. Results: We demonstrate for the first time that CCK 2 R is expressed not only in MTCs but in all samples of normal thyroid tissue. Using immunohistochemistry the receptor could be localized on calcitoninsecreting C-cells. The highest incidence of CCK 2 R expression in MTCs was observed in early-tumor stages, whereas CCK 2 R could not be detected in advanced or metastasized tumors. Conclusions: The expression of CCK 2 R in C-cells suggests a physiological function for gastrin and/or CCK in the regulation of calcitonin release, presumably related to bone and calcium metabolism. Moreover, these ligands might act as growth factors in MTCs. Efforts in the development of CCK 2 R scintigraphy for the detection of MTC lesions might have to consider a lower incidence of the receptor in advanced tumor stages.

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Section: Immunohistochemistrymentioning

confidence: 99%

Expression of the cholecystokinin 2-receptor in normal human thyroid gland and medullary thyroid carcinoma

Bläker

Weerth

Tometten

et al. 2002

European Journal of Endocrinology

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“…Apresenta como efeitos colaterais mais freqüentes sensação de aperto retro-esternal e epigastralgia, ambos bastante fugazes. É contra-indicado em portadores de doença cárdio-vascular, gestantes, idosos e crianças menores de 4 anos de idade (75).…”

Section: Rastreamento Bioquímicounclassified

Carcinoma medular da tireóide

Ezabella

Hayashida

Abelin

et al. 1998

Arq Bras Endocrinol Metab

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Recebido em 25/6/98 Revisado em 24/7/98 Aceito em 28/7/98 O CARCINOMA MEDULAR DA TIREÓIDE (CMT), identificado inicialmente como entidade clínico-patológica, em 1959, por Hazard e cols.(l) deriva das células C, produtoras de calcitonina. Tem características especí-ficas como presença de material amilóide, alta incidência de metástases em linfonodos cervicais e grau intermediario de malignidade, entre o carcinoma anaplásico e o carcinoma papilífero. Apesar de sua baixa incidência (3 a 12% dos carcinomas da tireóide), tem características bastante peculiares: 1) deriva das células C, originárias da crista neural, em contraste com as célu-las foliculares; 2) produz uma grande variedade de substancias bioativas, entre elas a calcitonina (CT), normalmente produzida pelas células C; 3) pode ocorrer de maneira esporádica (75 a 90%), ou sob a forma familiar (10 a 25%), com herança autossômica dominante. Nesta última, está geralmente associado a outras patologias, como parte das neoplasias endócrinas múltiplas tipo 2A e 2B (NEM 2A e NEM 2B). Pode também se apresentar sob a forma familiar isolada (CMTF)(2-8) (Tabela 1).O CMT tem sido diagnosticado com freqüência progressivamente maior, principalmente a sua forma hereditária, graças aos métodos de rastreamento entre familiares de indivíduos afetados. Assim, a forma hereditária chega a corresponder a até 25% dos casos em algumas séries(9).

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“…However, the recent discovery of the stimulatory effect of gastrin or pancreozymin on the secretion of calcitonin in the pig (Cooper et al 1971, Care et al 1971) and the inhibitory effect of calcitonin on the gastric secretion in man (Hesch et al 1971) has raised the possibility that calcitonin acts on the gastrointestinal organs. In view of these facts, we have studied the effect of calcitonin on the gastric secretion and furthermore on the development of experimental gastric ulcer in rat.…”

Section: Synopsismentioning

confidence: 99%