Thyroid Gland in Chronic Obstructive Pulmonary Disease

Miłkowska-Dymanowska, Joanna; Białas, Adam J.; Laskowska, Paulina; Górski, Paweł; Piotrowski, Wojciech J.

doi:10.5603/arm.2017.0006

Cited by 6 publications

(2 citation statements)

References 41 publications

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“…Thyroid dysfunction is associated with many changes in pulmonary physiology. [ 58 ] Clinical investigators have observed that OSAHS and hypothyroidism share several common clinical features, such as daytime sleepiness, slow reaction time, and memory decline. These features are commonly seen in both conditions.…”

Section: Discussionmentioning

confidence: 99%

Lack of associations between thyroid dysfunction and obstructive sleep apnea-hypopnea syndrome: A meta-analysis

Xiong,

Hu,

Huang

et al. 2023

Medicine

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Background: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a comprehensive syndrome with endocrine and metabolic complications. This review aims to explore the correlation between thyroid hormone levels and the severity of OSAHS in patients. Methods: The protocol for this meta-analysis has been registered on PROSPERO. Searches were carried out from the inception of the databases to July 18, 2023, utilizing 6 databases (PubMed, CNKI, EMBASE, Web of Science, Cochrane Library, China Biology Medicine, and Wanfang). Standardized mean difference (SMD) and correlation coefficients were used as the effect size measures. Additionally, random effects or fixed effects models were used for pooled analysis. Moreover, data were statistically evaluated with the help of STATA 11.0 and R 4.1.3. Results: This study included 23 articles that satisfied the pre-defined criteria. The prevalence of hypothyroidism and subclinical hypothyroidism in OSAHS patients was 6% and 8%, whereas hyperthyroidism had a prevalence of 2%. Moreover, thyroid hormone levels in OSAHS individuals exhibited no significant difference relative to healthy subjects. Subgroup analysis based on disease severity also established no significant changes in thyroid hormone levels between OSAHS individuals and controls. There was no significant correlation between the Apnea-Hypopnea Index (AHI) and free triiodothyronine (FT3), serum thyroid stimulating hormone (TSH), and free thyroxine (FT4) levels. Conclusion: The prevalence of thyroid dysfunction is relatively low in OSAHS individuals. Thyroid hormone levels show no significant difference between OSAHS patients and healthy subjects. Furthermore, there is no significant correlation between AHI and serum TSH, FT3, and FT4 levels. Based on existing data, the relationship between OSAHS and thyroid function remains controversial, and further in-depth research is warranted to validate the connection and elucidate the underlying mechanisms.

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Section: Discussionmentioning

confidence: 99%

Lack of associations between thyroid dysfunction and obstructive sleep apnea-hypopnea syndrome: A meta-analysis

Xiong,

Hu,

Huang

et al. 2023

Medicine

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“…Supporting this, Karadag et al [11] found a positive correlation between interleukin 6, which is a systemic inflammation marker, and total triiodotironine (TT3) and TT3/TT4 (total tyhroxine) in patients with stable COPD [11]. Smoking increases systemic inflammation independently from associating COPD and may affect thyroid functions [12]. Higher levels of serum total triiodothyronine (TT3) were found in young healthy smokers compared to non-smoking control subjects, which may suggest that smoking acts independently of coexistent diagnosis of COPD [13].…”

Section: Introductionmentioning

confidence: 93%

Comorbidities of patients with chronic obstructive pulmonary disease (COPD): thyroid abnormalities in stable COPD

Ilievska¹,

Mickovski²

2021

Medical Research Journal

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Objective: The aim of the study is to evaluate the prevalence of thyroid abnormalities in patients with stable chronic obstructive pulmonary disease (COPD) and the relationship between thyroid disorder and ventilatory function tests and arterial blood gas analyses.Material and methods: This cross-sectional study was conducted with 60 patients with stable COPD without diagnosed thyroid disorder before the study (37 males and 23 females aged 40-75) as the Investigated Group (IG) and 30 subjects from the general population without COPD as the Control Group (CG). They were matched by age, gender and body mass index with the IG. All patients underwent laboratory tests, thyroid hormones -free thyroxin (fT4), thyroid-stimulating hormone (TSH), and free triiodothyronine (fT3), pulmonary function tests (FEV 1 , FVC%, FEV 1 /FVC, FEF25-75%), and ABG parameters (PH, PaCO 2 , PaO 2 , HCO 3 , O 2 saturation). The severity level in patients with COPD was determined according to GOLD (Global Initiative for Chronic Obstructive Lung Disease) criteria and classified into four stages GOLD I, II, III, and IV.Results: Our results presented a statistically significant difference between prevalence of thyroid hormones abnormalities in stable COPD compared to controls 18 (30.0%) vs 3 (10.0%), p = 0.0355; p < 0.05).Thyroid dysfunction among COPD patients was more common in females than males. Serum level of TSH was lower than the normal range in 18 patients (30.0%) from the IG and in 3 (10.0%) from the CG, with a statistically significant difference, p = 0.0355; p < 0.05. Thyrotoxicosis with low serum TSH and a higher serum level of fT3, according to the referent range, was present in 8 patients (13.3%), and in no patients from the CG 0 (0.0%), p = 0.0375; p < 0.05. The prevalence of subclinical hyperthyroidism with low serum TSH and normal serum level of fT3 was higher in the IG -10 patients (16.7%) compared with 3 (10.0%) of the CG, but the difference was not statistically significant p = 0.3970. Acute exacerbation frequency of IG was significantly higher than in the CG (1.6 ± 0.42 and 0.82 ± 0.79 respectively; p < 0.0001).A positive significant relationship between acute exacerbation frequency and TSH values was found (p < 0.0001; r = 0.82). The mean values of fT3 in the IG were significantly increasing with the increased severity of COPD. The degree of airflow limitation in COPD (FEV 1 as a percentage of the predicted value, FEV 1 %pred) was significantly negatively correlated to fT3, Pearson correlation, (R = -0.525; p = 0.000; p < 0.01). FEV 1 %pred was positively correlated with TSH (R = 0.358; p = 0.005; p < 0.01). Significant negative correlations were present between fT3 levels and both PaO 2 and SO 2 in the IG, and elevation of fT3 was associated with higher PaCO2. Conclusion:The present study confirms that both clinical and subclinical hyperthyroidism was higher in patients with COPD compared to the non-COPD group. TSH and fT3 are related to lung function. A better understanding of the correlation between thyroid gland disord...

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