2000
DOI: 10.1006/bbrc.2000.3671
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Thyroid Oxidase (THOX2) Gene Expression in the Rat Thyroid Cell Line FRTL-5

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Cited by 64 publications
(53 citation statements)
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References 27 publications
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“…However, the DUOX are also expressed on the mucosal surfaces of the trachea and the bronchi (15) and in the airway epithelial cells (16,17), where it has been suggested that Duox1 is the isoform responsible for acid production and secretion in airways (16) and plays a critical role in mucin expression (18). DUOX2 was also expressed throughout the digestive tract, where it was found to be functional (19,20), in addition to the salivary gland and rectum (15).…”
Section: Duox2 (And Probablymentioning
confidence: 99%
See 1 more Smart Citation
“…However, the DUOX are also expressed on the mucosal surfaces of the trachea and the bronchi (15) and in the airway epithelial cells (16,17), where it has been suggested that Duox1 is the isoform responsible for acid production and secretion in airways (16) and plays a critical role in mucin expression (18). DUOX2 was also expressed throughout the digestive tract, where it was found to be functional (19,20), in addition to the salivary gland and rectum (15).…”
Section: Duox2 (And Probablymentioning
confidence: 99%
“…However, the DUOX are also expressed on the mucosal surfaces of the trachea and the bronchi (15) and in the airway epithelial cells (16,17), where it has been suggested that Duox1 is the isoform responsible for acid production and secretion in airways (16) and plays a critical role in mucin expression (18). DUOX2 was also expressed throughout the digestive tract, where it was found to be functional (19,20), in addition to the salivary gland and rectum (15).It has been suggested that Duox2, which was identified by purifying thyroid NADPH oxidase, may constitute the catalytic core of this enzyme and generate the H 2 O 2 used by Tpo to catalyze the biosynthesis of thyroid hormones at the apical surface of the thyrocytes (13). Although no functional Duoxbased H 2 O 2 -generating system has yet been reconstituted (21), this proposal is corroborated by a recent report of permanent and severe congenital hypothyroidism in a patient with a bial-* The costs of publication of this article were defrayed in part by the payment of page charges.…”
mentioning
confidence: 99%
“…As already shown in other tumor types, recent studies in thyroid cancer have demonstrated the prognostic significance of necrosis and proliferation, estimated by the number of mitoses (Akslen & LiVolsi 2000, Hiltzik et al 2006. Furthermore, immunohistochemistry may detect the expression of proteins involved in iodine metabolism (sodium iodine symporter (NIS), thyroglobulin (Tg), thyroid peroxidase (TPO), apical iodine transporter (AIT), and dual-oxidase (p138-DUOX)), FDG uptake (glucose transporter 1 (GLUT-1) and hexokinase; Dupuy et al 2000, De Deken et al 2002, Schönberger et al 2002, Lacroix et al 2004, and angiogenesis, such as vascular endothelial growth factor (VEGF) and VEGF receptor (VEGF-R) (Bunone et al 1999, Katoh et al 1999, Klein et al 2001, Lennard et al 2001). These three features were shown to be related to thyroid cancer prognosis.…”
Section: Introductionmentioning
confidence: 99%
“…Recently, a family of genes that are homologous to the human gp91 phox core unit has been discovered by molecular cloning from various somatic cell types. These include Nox1, 3, 4, 5 and Duox1 and Duox2, with gp91 phox being termed as Nox2 [7][8][9][10][11][12][13][14][15]. The novel non-phagocytic Nox/Duox proteins contain highly conserved binding sites for NADPH, FAD and heme.…”
Section: Introductionmentioning
confidence: 99%