Thyrotropin-Releasing Hormone Loaded and Chitosan Engineered Polymeric Nanoparticles: Towards Effective Delivery of Neuropeptides

Kaur, Sarabjit; Bhararia, Avani; Sharma, Krishna K.; Mittal, Sherry; Jain, Rahul; Wangoo, Nishima; Sharma, Rohit K.

doi:10.1166/jnn.2016.12431

Cited by 8 publications

(3 citation statements)

References 22 publications

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“…Due to the resistance forces between hydrophilic peptide and hydrophobic PLGA molecules, the diffusion of CGRP was very fast when contacted with the water phase which may result in the relatively lower loading efficiency of the peptide comparing to the double emulsion method [40][41][42]. However, the final loading efficiency, in this study, was comparable to other studies using the nanoprecipitation strategy with loading efficiencies ranging from 0.2% to 0.5% [43][44][45][46]. The PEG with hydrophilicity may retard the diffusion of the peptide which may lead to the higher loading efficiency comparing to the PLGA without modification.…”

Section: Fabrication and Characterization Of Nanoparticlessupporting

confidence: 59%

The PLGA nanoparticles for sustainable release of CGRP to ameliorate the inflammatory and vascular disorders in the lung of CGRP-deficient rats

et al. 2021

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The calcitonin gene-related peptide (CGRP) has been demonstrated relating to vascular and inflammatory regulations not only the nerve systems. As the anti-inflammation factor and the most potent vasodilator, the CGRP holds therapeutic potentials for the treatment of cardiovascular diseases which was, however, limited by its peptide nature and short half-life. With advantages in improving the stability, circulation time and protection from degradation, the nanoparticles were promising as delivery carriers for the peptide. Nevertheless, few nanoparticulate systems were developed to deliver the CGRP peptide for the modulation of vascular or inflammatory functions instead of neural regulation. In this study, the CGRP was encapsulated into the poly (lactic-co-glycolic acid) (PLGA) nanoparticle for sustained release of CGRP in vivo . The nanoparticles recovered the systemic level of CGRP and the vascular inflammatory factors in the CGRP +/− rats comparing to the administration of (Dulbecco's Phosphate Buffered Saline) DPBS or peptide only. With the decrease of vascular wall thickness and the attenuation of the T cell infiltration in the lung, the polymer based CGRP delivery system showed potentials to facilitate the therapeutic effects of the CGRP which may help for the development of CGRP-based therapy in vascular and inflammatory disorder related diseases.

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Section: Fabrication and Characterization Of Nanoparticlessupporting

confidence: 59%

The PLGA nanoparticles for sustainable release of CGRP to ameliorate the inflammatory and vascular disorders in the lung of CGRP-deficient rats

et al. 2021

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“…In the treatment of AD, soluble CTS nanoparticles were also found to safely and efficiently deliver piperine to targeted sites and multiply, which can reduce the oral dose by 20 times [ 99 ]. In this paper, Kaur et al [ 100 ] reported that the synthesis and stability studies of novel CTS engineered thyrotropin-releasing hormone encapsulation poly (lactide- co -glycolide) showed the potential membrane penetrating and effective delivery of neuropeptides, which were used in the treatment of brain/spinal injury and certain CNS disorders, including schizophrenia, AD, depression, etc. Rosmarinic acid-loaded polyacrylamide-chitosan-poly (lactide- co -glycolide) nanoparticles were grafted with cross-reacting material 197 and apolipoprotein E to pass across the BBB and rescuing neurodegeneration.…”

Section: Biological Activity Of Cts and Cos And Its Derivatives Inmentioning

confidence: 99%

Application of Chitosan, Chitooligosaccharide, and Their Derivatives in the Treatment of Alzheimer’s Disease

Ouyang

Zhao

et al. 2017

Marine Drugs

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Classic hypotheses of Alzheimer’s disease (AD) include cholinergic neuron death, acetylcholine (ACh) deficiency, metal ion dynamic equilibrium disorder, and deposition of amyloid and tau. Increased evidence suggests neuroinflammation and oxidative stress may cause AD. However, none of these factors induces AD independently, but they are all associated with the formation of Aβ and tau proteins. Current clinical treatments based on ACh deficiency can only temporarily relieve symptoms, accompanied with many side-effects. Hence, searching for natural neuroprotective agents, which can significantly improve the major symptoms and reverse disease progress, have received great attention. Currently, several bioactive marine products have shown neuroprotective activities, immunomodulatory and anti-inflammatory effects with low toxicity and mild side effects in laboratory studies. Recently, chitosan (CTS), chitooligosaccharide (COS) and their derivatives from exoskeletons of crustaceans and cell walls of fungi have shown neuroprotective and antioxidative effects, matrix metalloproteinase inhibition, anti-HIV and anti-inflammatory properties. With regards to the hypotheses of AD, the neuroprotective effect of CTS, COS, and their derivatives on AD-like changes in several models have been reported. CTS and COS exert beneficial effects on cognitive impairments via inhibiting oxidative stress and neuroinflammation. They are also a new type of non-toxic β-secretase and AChE inhibitor. As neuroprotective agents, they could reduce the cell membrane damage caused by copper ions and decrease the content of reactive oxygen species. This review will focus on their anti-neuroinflammation, antioxidants and their inhibition of β-amyloid, acetylcholinesterase and copper ions adsorption. Finally, the limitations and future work will be discussed.

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“…Todas as imagens, tanto as topográficas quanto as de contraste de fase, foram fornecidas simultaneamente pelo equipamento durante a varredura de cada área. A técnica utilizada para a caracterização das partículas foi o espalhamento de luz dinâmico (DLS), que é amplamente utilizada para a avaliação físico-química de partículas, sendo relatada em diversos trabalhos envolvendo carreadores lipídicos (Marcato, 2009;Svilenov;Tzachev, 2014; Geszke-Moritz; Moritz, 2016) e poliméricos (Kaur et al, 2016). Dentre as vantagens da técnica de DLS estão a praticidade, facilidade de operação e velocidade na aquisição dos dados (Bohren;Huffman, 1983), vantagens estas que contribuíram para a escolha desta técnica para a etapa de caracterização de tamanho, índice de polidispersão e potencial zeta das partículas.…”

Section: Shimadzu Corporation Jpn) Na Faculdade De Filosofia Ciênciunclassified

Encapsulamento de epigalocatequina-3-Galato (EGCG) em nanopartículas para uso tópico bucal: desenvolvimento, caracterização e determinação da atividade antimicrobiana <i>in vitro</i>

Moreno¹

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Agradeço à minha orientadora Prof a. Dr a. Andiara De Rossi, pela confiança depositada em mim, por sua generosidade e bondade. Por transmitir de forma simples seus grandes conhecimentos e experiências, pelo apoio e orientação e por ser um grande exemplo. Agradeço pela forma carinhosa com que sempre me tratou, pela atenção dada a mim em todos os momentos, por guiar minhas escolhas, pelos conselhos dados, pelas sinceras conversas, enfim, pelo meu bem querer. Andi, sou imensamente grata por tudo! Agradeço à Prof a. Dr a. Priscyla Danielly Marcato Gaspari, pela atenção em todos os momentos, pelos conhecimentos compartilhados e pela paciência em me ajudar a caminhar por este nano-universo tão novo para mim. Obrigada por sua dedicação, carinho, companheirismo e pelos conselhos. Obrigada profa. Pri, pela confiança! Obrigada também ao Prof. Alexandre Gaspari, pelos conhecimentos compartilhados, pelo carinho e alto-astral! Ter conhecido vocês, foi um presente de Deus! Ao Prof. Dr. Sérgio Luiz de Souza Salvador, pelas valiosas contribuições e pelo modo gentil com que me recebeu em seu laboratório. Obrigada pelo apoio, pela ajuda e por compartilhar comigo seus conhecimentos e suas experiências. Obrigada por ter acreditado em mim! Agradeço à amiga Marina Constante Gabriel Del Arco, técnica do laboratório de Microbiologia da Faculdade de Ciências Farmacêuticas, pelo apoio, pelos conhecimentos compartilhados, pela paciência e por não medir esforços em me ajudar nos ensaios microbiológicos. Agradeço também pelas conversas sinceras, pelos conselhos e pelos momentos de descontração. Você é muito especial para mim! AGRADECIMENTOS Agradeço ao Prof. Dr. Roberto Santana da Silva, pelo apoio, pelos conhecimentos compartilhados e por ser um grande exemplo de professor. Agradeço pelas conversas sempre muito produtivas e esclarecedoras. Obrigada por ceder o laboratório de Química Analítica para as análises no HPLC. Agradeço à técnica do laboratório de Química Analítica, Juliana Cristina Biazzoto de Moraes, por ter aceitado o desafio de realizar as análises cromatográficas no HPLC e fazê-las com muito empenho e determinação. Obrigada pela atenção e disposição que sempre estiveram presentes por sua parte nesses dois anos. Ju, muito obrigada pela forma educada e carinhosa com que sempre me tratou. Agradeço à Prof a. Dr a. Renata Fonseca Vianna Lopez, por gentilmente disponibilizar o laboratório de Farmacotécnica para realizar as análises no Zeta Sizer.

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Thyrotropin-Releasing Hormone Loaded and Chitosan Engineered Polymeric Nanoparticles: Towards Effective Delivery of Neuropeptides

Cited by 8 publications

References 22 publications

The PLGA nanoparticles for sustainable release of CGRP to ameliorate the inflammatory and vascular disorders in the lung of CGRP-deficient rats

The PLGA nanoparticles for sustainable release of CGRP to ameliorate the inflammatory and vascular disorders in the lung of CGRP-deficient rats

Application of Chitosan, Chitooligosaccharide, and Their Derivatives in the Treatment of Alzheimer’s Disease

Encapsulamento de epigalocatequina-3-Galato (EGCG) em nanopartículas para uso tópico bucal: desenvolvimento, caracterização e determinação da atividade antimicrobiana <i>in vitro</i>

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