Time Course for the Changes of Serum Lipoproteins and Apolipoprotein T Concentrations after Major Surgical Trauma in Man

Abstract

Trauma induces changes in the serum lipoprotein pattern in man. A characteristic apolipoprotein, named apolipoprotein T existing in its isoforms T-I to T-IV, in the high density lipoprotein (HDL) fraction of serum, also appears in response to trauma. In this report eight patients operated on for abdominal aortic aneurysms were studied concerning the time dependency in changes of serum lipoproteins and the appearance of apolipoprotein T. Blood samples for lipoprotein analysis were taken preoperatively, postoperatively on days 1, 2, 4, 6 and thereafter twice a week until discharge from the hospital. The serum lipoprotein concentrations were compared with those from a group of healthy men. The most striking abnormalities were found in serum VLDL where both concentrations of triglycerides and cholesterol decreased during the first 2 days by more than 50%, compared to the initial level, and remained low for about 1 week. Also the concentration of LDL cholesterol in serum decreased about 40% from the preoperative value during the first days. Serum HDL cholesterol either increased during the first 2 days in those patients with a low preoperative concentration or stayed on a subnormal level during the first 4 days. After day 4 the serum HDL cholesterol decreased and reached the minimum level on days 10 to 13. Already on day 1 after trauma apolipoprotein T had reached a high level in order to stay high for several weeks. The apolipoprotein T isoforms had different appearance with time and varied independently of serum cholesterol in HDL.

Changes in lipoprotein profiles during intense military training.

“…During various pathological states, such as trauma, acute infections, myocardial in farctions, and surgery, decreases in TC concentration of a similar magnitude to our study have been reported [17][18][19]. It is not known if the decline in TC has similar underlying physiological mechanisms and may represent a type of response to severe stress.…”

Raman spectroscopy of serum: A study on ‘pre’ and ‘post’ breast adenocarcinoma resection in rat models

“…Six rats were visually and palpably normal six weeks post surgery and were further used for blood collection (post surgery samples). Collection of blood six weeks post surgery ensures minimal influence of inflammatory, surgical trauma and tissue loss associated changes in serum, since these changes do not persist for more than 5–7 days . No additional drugs or treatment were administered to these rats, except topical application of 5% Povidone Iodine (Wockhardt Health Care) over surgical wound to prevent infection.…”

The Role of Cholesterol in Assessing the Condition of the Surgical Patients

“…Surgery is not just a local tissue trauma but also leads to metabolic and hormonal changes in the organism, which can be designated as postoperative disease or post-aggression syndrome [24 onset of postoperative complications and the patients' reaction to treatment. The observed hypocholesterolemia [25][26][27] is related to reduced LDL amounts, but also a lower level of HDL. Therefore, there is a correlation between the severity of surgical intervention and the rapid reduction of cholesterol-containing lipoproteins in the serum.…”