Time–course monitoring of serum amyloid A in a cat with pancreatitis

Abstract

Time-course changes in the concentration of serum amyloid A (SAA), a major acute phase protein, were measured in a cat with pancreatitis over an 831-day period and compared with changes in WBC count and feline trypsin-like immunoreactivity (fTLI). SAA concentration was increased at the onset of the disease and gradually decreased over 5 days of treatment with an improvement in the clinical condition. In contrast, fTLI concentration and WBC count were not increased at the onset of the disease but increased gradually during the 5 days of treatment. Long-term monitoring from days 68 to 831 revealed a good correlation between SAA concentration and the reoccurrence of clinical signs in the cat; however, WBC count did not increase even with the exacerbation of disease. These findings suggest that the SAA concentration may be a useful marker for evaluating response to treatment and disease exacerbation in feline pancreatitis.

Acute phase response in Chinese soft-shelled turtle (Trionyx sinensis) with Aeromonas hydrophila infection

“…With rapid resolution of the symptoms in this cat, SAA returned to normal levels, whereas the WBC count was just beginning to increase (Tamamoto et al, 2009). In mammals, SAA is synthesized extrahepatically by different cellular types like monocytes/macrophages (Yamada et al, 2000).…”

Acute Phase Proteins as Biomarkers in Animal Health and Welfare

“…The serum concentration of SAA may be also a useful marker for evaluating response to treatment and disease exacerbation in feline pancreatitis (Tamamoto et al, 2009). Elevated concentrations of AGP have been also found in serum of cats with lymphoma although did not provide useful information regarding response or survival of affected animals (Correa et al, 2001).…”

“…On the other hand, CRP represents an interesting parameter to measure in other processes, just as in canine lymphoma, where a significant decrease in CRP values was associated to remission after treatment with specific cytotoxic drugs (Nielsen et al, 2007). Specific APPs have been reported as value tools in monitoring both infectious diseases, just as CRP and Cp (but not SAA or Hp) in leishmaniasis (Martínez-Subiela et al, 2003) or CRP (but not Hp) in trypanosomiasis (N'dungu et al, 1991), and inflammatory processes, just as SAA in feline acute pancreatitis (associated with remission and recurrence) (Tamamoto et al, 2009) or Hp in bovine respiratory disease (Carter et al, 2002). In other conditions, just as canine hemolytic anemia, the changes in APPs were not useful to monitor the success of specific treatments (Griebsch et al, 2009;Mitchell et al, 2009).…”

“…Moreover, AGP has been shown to be useful in monitoring the early interferon (IFN) treatment of parvoviral infected cats (Paltrinieri et al, 2007a). SAA has been reported as a useful tool in the diagnosis, monitoring and treatment of feline pancreatitis (Tamamoto et al, 2009). An enhancement in the concentration of AGP and Hp has been observed in anemic cats suffering from pyothorax, abscesses or fat necrosis (Ottenjann et al, 2006).…”

Serum Amyloid A Promotes Invasion of Feline Mammary Carcinoma Cells

“…Because of the dramatic increase in serum SAA concentration during inflammation, serum SAA concentration is used as an inflammatory marker in humans [13] and cats [24]. Elevated SAA concentration has been described in various inflammatory and infectious diseases [3, 25].…”