Time course of carregeenan-induced inflammation during experimental therapy

Aleksandrov, P. N.; Speranskaya, T. V.; Bobkov, Yu. G.; Zagorevskii, V. A.; Zykov, D. A.

doi:10.1007/bf00836108

Cited by 3 publications

(3 citation statements)

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“…These experiments described inflammation induced by carrageenan after application to the cheek of guinea-pigs (Yavuz and Akbay 1989) and to the cheek pouch in hamsters (Aleksandrov et al 1986;Aleksandrov and Speranskaya 1988). However, it is difficult to make valid comparisons between our work and these earlier studies, for a variety of reasons.…”

Section: Discussionmentioning

confidence: 65%

“…For instance, only the abstracts are in English and these do not mention the doses of carrageenan used or the time course of the inflammation. Moreover, the inflammatory variables measured were different-''pathological process' ' Aleksandrov et al 1986; changes in the microvasculature (Aleksandrov and Speranskaya 1988) and histopathological changes (Yavuz and Akbay 1989). Finally, comparison of inflammation between species adds a new layer of assumptions that weaken the strength of that assessment.…”

Section: Discussionmentioning

confidence: 99%

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Tissue-selective inflammation in the oral cavity of the rat

et al. 2016

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In the current study, carrageenan (CG; 100-1000 μg/site) was injected intraorally in the cheeks of Holtzman or Wistar rats to evaluate the consequences of administration of a non-immunogenic stimulus in the orofacial region. Subsequent inflammation was measured as oedema (increased thickness of the cheek wall using digital calipers), relative to the other cheek injected with saline. Oedema formation and tissue collection for histopathological studies were assessed at 0.5, 1, 2, 3, 4, 6, 24, 48, 72, 96, 120 and 144 h after injection. In parallel, other groups of rats were injected with CG in the hind paw, to provide a reference response. The inhibitor of prostaglandin biosynthesis, indomethacin, and antagonists of histamine, serotonin and NK1 receptors were injected s.c., 0.5 h before CG. CG induced a dose-related oedema more rapidly from 0 to 2 h which lasted for at least 72 h, showing a biphasic profile (peak at 2 and 24 h), compared with the monophasic oedema induced in rat paws (maximal duration of 24 h). Histopathological analysis of the CG-injected cheek revealed oedema formation with little leukocyte recruitment at 1-3 h, mast cell degranulation at 6 h, and a mixed polymorphonuclear and mononuclear cell infiltrate by 24 h. Histamine and serotonin antagonists and indomethacin, but not the NK1 antagonist, decreased cheek oedema in the first 4 h following carrageenan. Taken together, our data indicated important differences in the pattern of inflammation between the oral cavity and the paw which will determine the therapeutic approach to the treatment of inflammatory conditions in the oral cavity.

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Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Tissue-selective inflammation in the oral cavity of the rat

et al. 2016

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“…Rutin (C 27 H 30 O 16 ) (Scheme ), a glycoside of the flavonol quercetin, is one of the major polyphenols available. This compound has been extensively studied and is known to exhibit antitumor, anti-inflammatory, antiplatelet, and vasodilation properties. Nevertheless, due to its poor solubility (the solubility at T = 298.15 K is (0.66 ± 0.03) × 10 −5 (mole fraction value)), it shows a slow dissolution rate in solid oral forms, and the drug absorption from the gastrointestinal tract is generally slow and irregular, thus restricting its use in therapy .…”

Section: Introductionmentioning

confidence: 99%

Cationic Polyelectrolytes as Drug Delivery Vectors: Calorimetric and Fluorescence Study of Rutin Partitioning

2010

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The interaction between hydrophobically modified cationic polysaccharides based on dextran and a flavonoid drug (Rutin) was studied by isothermal titration calorimetry (ITC) and fluorescence spectroscopy, in order to assess the factors responsible for the interaction and characterize its energetics, as well as for evaluating their encapsulation capacity, for possible applicability of these polymers as drug delivery vectors. To address the importance of the hydrophobic pendant groups in the solution behavior of these polymer/drug systems, we also studied the interaction of Rutin with a cationic surfactant, cetyltrimethylammonium chloride (CTAC). The interaction enthalpies and drug binding constants for D40R30/Rutin systems were derived from ITC through a simple binding model. The binding constants were independently derived from fluorescence results, with fair agreement between the parameters obtained from both methods. By changing the Rutin concentration, we were able to get evidence for a solubility enhancement induced by the presence of the polymers, a promising effect regarding its use to improve bioavailability.

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