Time Course of Cellular Infiltration in the Nasal Mucosa during the Immediate Allergic Reaction

Lozewicz, S.; Gomez, E.; Chalstrey, S; Gatland, D. J.; Davies, Robert J.

doi:10.1159/000235441

Cited by 15 publications

(4 citation statements)

References 18 publications

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“…At T 24 , however, more than 50% of MC TC cells in the nasal lamina propria of allergic rhinitis patients (as compared with only 10% in controls) had lost their granule contents, which is in accordance with findings during natural exposure (26). Lozewicz and Wagenmann have shown that unilateral nasal allergen challenge results in an immediate reduction in the number of stainable mast cells (34) and in a delayed increase in basophil numbers and histamine production in the contralateral unstimulated nostril (35). Lozewicz and Wagenmann speculated that a neural reflex mechanism was most likely to contribute to mast cell degranulation in the unchallenged nostril.…”

Section: Discussionsupporting

confidence: 82%

Segmental Bronchoprovocation in Allergic Rhinitis Patients Affects Mast Cell and Basophil Numbers in Nasal and Bronchial Mucosa

Braunstahl

Overbeek

Fokkens

et al. 2001

Am J Respir Crit Care Med

183

113

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Mast cells and basophils are cells that play an important role in the initiation and control of allergic inflammation in asthma and rhinitis. This study was undertaken to determine the presence and dynamics of mast cells and basophils in the nasal and bronchial mucosa of allergic rhinitis patients after segmental bronchial provocation (SBP). Eight nonasthmatic, grass pollen-allergic rhinitis patients and eight healthy controls were included. Bronchial and nasal biopsies, as well as blood samples, were taken before (T(0)) and 24 h (T(24)) after SBP. Immunohistochemical staining was performed for mast cells (tryptase and chymase; phenotypes MC(T), MC(TC), MC(C)) and basophils (BB1). In the bronchial mucosa, the number of BB1(+) cells increased significantly (p < 0.05) in allergic rhinitis patients after SBP. In the nasal mucosa, the numbers of MC(C) and MC(TC) cells decreased significantly, whereas the numbers of [BB1(+)] cells increased significantly in allergic rhinitis patients after SBP (p < 0.05). In blood, the number of basophils decreased (p < 0.05) and the level of interleukin (IL)-5 increased (p < 0.05) in atopic patients after SBP. No significant changes could be observed in healthy controls. This study shows that SBP in nonasthmatic allergic rhinitis patients reduces numbers of mast cells in the nose as a result of enhanced degranulation. At the same time, there is evidence for an influx of basophils from the blood into the nasal and bronchial mucosae.

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Section: Discussionsupporting

confidence: 82%

Segmental Bronchoprovocation in Allergic Rhinitis Patients Affects Mast Cell and Basophil Numbers in Nasal and Bronchial Mucosa

Braunstahl

Overbeek

Fokkens

et al. 2001

Am J Respir Crit Care Med

183

113

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“…Recently, Fc^RI-bearing monocytes have been demonstrated in atopic patients, and these may also contribute to the 29C6-I-cells in our sections (10). Since the number of toluidine blue+ cells in the epithelium of our sections was very low, we speculate that mast cells migrate into the nasal epithelium, degranulate (11), and thus decrease in stainability for the most part.…”

Section: Discussionmentioning

confidence: 66%

Demonstration of the high‐affinity IgE receptor (Fc_ɛRI) on Langerhans' cells of diseased nasal mucosa

Haas

Hamann

Grabbe

et al. 1997

Allergy

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Langerhans' cells in the skin have recently been shown to bind IgE molecules via the high-affinity IgE receptor (Fc epsilon RI). Using two highly specific antibodies against the antibody-binding alpha-chain of this receptor, 29C6 and 6F7, we demonstrate by immunohistochemistry and immunoelectron microscopy that Langerhans' cells of diseased nasal mucosa can express the Fc epsilon RI. Tissue sections from hyperplastic nasal conchae and nasal polyps of atopic and nonatopic patients have shown no basic differences in epithelial Fc epsilon RI-bearing cells. Only a few cells expressed the low-affinity IgE receptor (Fc epsilon RII) (Tü1 antibody) in some sections. These findings suggest that Langerhans' cells play an important role in the induction of transepithelial IgE-mediated allergy and in the mediation of inflammation of the nasal mucosa via their Fc epsilon RI.

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“…l V a s d allergy is actually more difficult to investigate. particularly in humans, as we found in a study carried out in 1990 (14), in which we looked at unilateral allergen challenge. Predictably, an increase in nasal airway resistance (NAR) occurred in the nostril after allergen challenge, and examination of biopsies from the challenged nostril showed that this was accompanied by mast cell degranulation and an early burst of eosinophils.…”

Section: Eosinophilsmentioning

confidence: 87%

Clinical implications of the pharmacological profile of Tilarin

Davies

1996

Allergy

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The pharmacological activity of nedocromil sodium is extensive and the compound should affect a variety of inflammatory processes by preventing activation of the involved cells or blocking release of their mediators. Some in vitro actions of nedocromil sodium are particularly relevant to the mechanisms of allergic rhinitis, and the response of the nasal epithelium to pollutants such as ozone. The effects of nedocromil sodium on mucosal mast cells, eosinophils, sensory nerves and nasal epithelial cells can each be linked to its potential clinical effectiveness by our own biopsy studies from patients with active allergic rhinitis. Nedocromil sodium has been shown to modulate production of a number of powerful cytokines, such as GM-CSF and TNF alpha, which are produced by the human nasal epithelium, as well as by involved inflammatory cells and lymphocytes, and which orchestrate the inflammatory response to allergen or to pollutant provocation. So, in addition to inhibiting activated mast cells and eosinophils, nedocromil sodium acts on the nasal epithelium itself to prevent further accumulation of these cells and thus to break the inflammatory chain of events. On this evidence of its preclinical activity, nedocromil sodium promises to become a very useful topical treatment for allergic rhinitis.

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Time Course of Cellular Infiltration in the Nasal Mucosa during the Immediate Allergic Reaction

Cited by 15 publications

References 18 publications

Segmental Bronchoprovocation in Allergic Rhinitis Patients Affects Mast Cell and Basophil Numbers in Nasal and Bronchial Mucosa

Segmental Bronchoprovocation in Allergic Rhinitis Patients Affects Mast Cell and Basophil Numbers in Nasal and Bronchial Mucosa

Demonstration of the high‐affinity IgE receptor (Fc_ɛRI) on Langerhans' cells of diseased nasal mucosa

Clinical implications of the pharmacological profile of Tilarin

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Time Course of Cellular Infiltration in the Nasal Mucosa during the Immediate Allergic Reaction

Cited by 15 publications

References 18 publications

Segmental Bronchoprovocation in Allergic Rhinitis Patients Affects Mast Cell and Basophil Numbers in Nasal and Bronchial Mucosa

Segmental Bronchoprovocation in Allergic Rhinitis Patients Affects Mast Cell and Basophil Numbers in Nasal and Bronchial Mucosa

Demonstration of the high‐affinity IgE receptor (FcɛRI) on Langerhans' cells of diseased nasal mucosa

Clinical implications of the pharmacological profile of Tilarin

Contact Info

Product

Resources

About

Demonstration of the high‐affinity IgE receptor (Fc_ɛRI) on Langerhans' cells of diseased nasal mucosa