2019
DOI: 10.1016/j.bbr.2019.01.058
|View full text |Cite
|
Sign up to set email alerts
|

Time-dependent protective effects of morphine against behavioral and morphological deficits in an animal model of posttraumatic stress disorder

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
9
0

Year Published

2020
2020
2023
2023

Publication Types

Select...
7

Relationship

0
7

Authors

Journals

citations
Cited by 20 publications
(10 citation statements)
references
References 91 publications
1
9
0
Order By: Relevance
“…The increase of thin spines in adrenalectomized rats was lower when compared to morphine-treated intact rats, with no change detected in stubby spines within the shell of NAc (Geoffroy et al 2019 ). These findings agree with the results of another report investigating the impact of morphine in the post-traumatic stress disorder (PTSD) model (RaiseAbdullahi et al 2019 ). Young–adult rats exposed to a single episode of stress have received a morphine injection at four different timepoints (0, 6, 12, 24 h).…”
Section: Opioids In General Anesthesia and Spine Remodelingsupporting
confidence: 92%
See 1 more Smart Citation
“…The increase of thin spines in adrenalectomized rats was lower when compared to morphine-treated intact rats, with no change detected in stubby spines within the shell of NAc (Geoffroy et al 2019 ). These findings agree with the results of another report investigating the impact of morphine in the post-traumatic stress disorder (PTSD) model (RaiseAbdullahi et al 2019 ). Young–adult rats exposed to a single episode of stress have received a morphine injection at four different timepoints (0, 6, 12, 24 h).…”
Section: Opioids In General Anesthesia and Spine Remodelingsupporting
confidence: 92%
“…At 25d post-stress, morphine-treated groups showed increased dendritic spines, with the highest effects observed in the group injected with morphine 24 h after inducing a stress response. Of note, the stimulating effects of morphine on dendritic spine formation were antagonized by naloxone (RaiseAbdullahi et al 2019 ). Another study in mice also using chronic (6-day) morphine treatment followed by abstinence for 2 months showed an increase in spine density in the frontal cortex and NAc, which persisted over 2 months.…”
Section: Opioids In General Anesthesia and Spine Remodelingmentioning
confidence: 99%
“…However, the fish spent significant time in the non-preferred compartment due to conditioned avoidance, hence, the behavioral parameters quantified are likely to have originated from the non-preferred chamber. In rodents, the protective effect of morphine on fear memory and responses appears after 6 h but not immediately after the trauma given, and the most effective response is observed when morphine treatment is given 24 h after the traumatic event 49 . However, in the present study, single morphine treatment 30-min after AS-induced fear stimuli successfully reduced expression of ASconditioned avoidance of fish, which is much shorter time than that in rats.…”
Section: Discussionmentioning
confidence: 99%
“…Next day (Day-3), prior to post-conditioning assessment, the fish was again immersed in morphine solution for 30 min. This was because the protective effect of morphine on fear memory and responses has been demonstrated to be most effective 24 h or 48 h after the traumatic event 6,49 . The dose for morphine was chosen based on a previous study in adult zebrafish 66 .…”
Section: Post-conditioning (Day-3)mentioning
confidence: 99%
“…Low doses of opioids have been shown to reduce symptoms of air hunger and breathlessness in both acute and chronic states of dyspnea, 48,49 and an animal model of physiological and emotional stress has shown behavioral and structural neurologic benefits associated with use of morphine. 50 Propofol, a highly effective amnestic sedative, has been shown to be relatively ineffective at suppressing activation of the amygdala; that is, patients may still develop maladaptive fear responses to stimuli in the absence of conscious memories. 51,52 Although its effect on dyspnea has not been studied, deep sedation with propofol fails to diminish pain-related activations in the cerebral cortex.…”
Section: Drugs With Antidyspnea Effects May Hold Promisementioning
confidence: 99%