Time-Frequency Characterization of Cerebral Hemodynamics of Migraine Sufferers as Assessed by NIRS Signals

Molinari, Filippo; Rosati, Samanta; Liboni, William; Negri, Emanuela De; Mana, Ornella; Allais, Gianni; Benedetto, Chiara

doi:10.1155/2010/459213

Cited by 11 publications

(8 citation statements)

References 26 publications

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“…In conclusion, we propose the joint approach of NIRS recordings, time and time-frequency analysis, and supervised/unsupervised clustering techniques as suitable in physiological and neuroscience experimental protocols [9,10]. …”

Section: Resultsmentioning

confidence: 99%

Time and time-frequency analysis of near-infrared signals for the assessment of ozone autohemotherapy long-term effects in multiple sclerosis

Lintas

Molinari

Simonetti

et al. 2013

2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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Time and time-frequency analysis of near-infrared signals for the assessment of ozone autohemotherapy long-term effects in multiple sclerosis / Lintas G.; Molinari F.; Simonetti V.; Franzini M.; Liboni W.. -2013Liboni W.. - (2013  Abstract-Ozone autohemotherapy is an emerging therapeutic technique that is gaining increasing importance in treating neurological disorders. A validated and standard methodology to assess the effect of such therapy on brain metabolism and circulation is however still lacking. We used a near-infrared spectroscopy system (NIRS) to monitor the cerebral oxygenation of 9 subjects: 4 remitting-relapsing multiple sclerosis (MS) sufferers and 5 controls. Subjects were tested before, during, and after ozone autohemotherapy. We monitored the concentration changes in the level of oxygenated and deoxygenated haemoglobin, and in the level of the Cytochrome-c-oxidase (CYT-c). From the time and timefrequency analysis of the NIRS signals we extracted 128 variables, which were used to characterize the metabolic brain pattern during the therapy. We showed that by using only 7 NIRS variables out of 128 it is possible to characterize the metabolic brain pattern of the two groups of subjects. The MS subjects showed a marked increase of the CYT-c activity and concentration about 40 minutes after the end of the autohemotherapy, possibly revealing a reduction of the chronic oxidative stress level typical of MS sufferers. From a technical point of view, this preliminary study showed that NIRS could be useful to show the effects of ozone autohemotherapy at cerebral level, in a long term monitoring. The clinical result of this study is the quantitative measurement of the CYT-c level changes in MS induced by ozone autohemotherapy.

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Section: Resultsmentioning

confidence: 99%

Time and time-frequency analysis of near-infrared signals for the assessment of ozone autohemotherapy long-term effects in multiple sclerosis

Lintas

Molinari

Simonetti

et al. 2013

2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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“…NIRS data were processed with a time-frequency distribution D xx ( t , f ) belonging to Cohen's class, and the Choi-Williams (CW) distribution was used as kernel with selectivity set to 0.5 to preserve a suitable compromise between lower attenuation of interference terms, and cleaner representation. A complete description of the custom developed time-frequency toolbox and of the processing technique is available [27]. Briefly, this toolbox firstly computes the instantaneous autocorrelation function of a time series x [ n ], then obtains the corresponding ambiguity function by an inverse Fourier transform, applies the CW kernel, and finally obtains the D xx ( t , f ) by a double Fourier transform from the lags to the time and frequency variables.…”

Section: Methodsmentioning

confidence: 99%

Effect of Ocular Movements during Eye Movement Desensitization and Reprocessing (EMDR) Therapy: A Near-Infrared Spectroscopy Study

et al. 2016

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IntroductionEye Movement Desensitization and Reprocessing (EMDR) is a psychotherapeutic treatment resolving emotional distress caused by traumatic events. With EMDR, information processing is facilitated by eye movements (EM) during the recall of a traumatic memory (RECALL). The aim of this study is to investigate the effects of ocular movements of EMDR on the hemodynamics of the prefrontal cortex (PFC).Material and MethodsTwo groups were recruited: a trial group (wEM) received a complete EMDR treatment, whereas a control group (woEM) received a therapy without EM. PFC hemodynamics was monitored by near-infrared spectroscopy during RECALL and during focusing on the worst image of the trauma (pre-RECALL). The parameters of oxy- (oxy-Hb), and deoxy-hemoglobin (deoxy-Hb) were acquired and analyzed in time domain, by calculating the slope within pre-RECALL and RECALL periods, and in the frequency domain, by calculating the mean power of oxy-Hb and deoxy-Hb in the very-low frequency (VLF, 20–40 mHz) and low frequency (LF, 40–140 mHz) bandwidths. We compared pre-RECALL with RECALL periods within subjects, and pre-RECALL and RECALL parameters of wEM with the corresponding of woEM.ResultsAn effect of group on mean slope of oxy-Hb and deoxy-Hb in pre-RECALL and oxy-Hb in RECALL periods was observed. wEM showed a lower percentage of positive angular coefficients during pre-RECALL with respect to RECALL, on the opposite of woEM. In the frequency domain, wEM had significant difference in oxy-Hb and deoxy-Hb LF of left hemisphere, whereas woEM showed no difference.Discussion and ConclusionWe observed the effect of EM on PFC oxygenation during EMDR, since wEM subjects showed a mean increase of oxy-Hb during RECALL and a decrease during pre-RECALL, as opposed to woEM. Frequency analysis evidenced a reduction of activity of sympathetic nervous system in wEM group during pre-RECALL. Our outcomes revealed a different hemodynamics induced by eye movements in wEM with respect to woEM group.

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“…These different properties, the concentration of each haemoglobin type, can be easily estimated by irradiating the tissue at two separate wavelengths [16]. Features extracted from NIRS recordings of diabetics during exercise have proven to be useful to assess the neuromuscular and peripheral pattern [17].…”

Section: Introductionmentioning

confidence: 99%

“…NIRS signals can typically tend to present a marked nonstationary nature [17,18]. Very low frequency components associated with long-term regulatory mechanisms makes the baseline of the NIRS signals vary [19], and the signal power depends on the local metabolic rate and oxygen consumption.…”

Section: Introductionmentioning

confidence: 99%

Empirical mode decomposition analysis of near-infrared spectroscopy muscular signals to assess the effect of physical activity in type 2 diabetic patients

Molinari

Martis²,

Acharya

et al. 2015

Computers in Biology and Medicine

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Time-Frequency Characterization of Cerebral Hemodynamics of Migraine Sufferers as Assessed by NIRS Signals

Cited by 11 publications

References 26 publications

Time and time-frequency analysis of near-infrared signals for the assessment of ozone autohemotherapy long-term effects in multiple sclerosis

Time and time-frequency analysis of near-infrared signals for the assessment of ozone autohemotherapy long-term effects in multiple sclerosis

Effect of Ocular Movements during Eye Movement Desensitization and Reprocessing (EMDR) Therapy: A Near-Infrared Spectroscopy Study

Empirical mode decomposition analysis of near-infrared spectroscopy muscular signals to assess the effect of physical activity in type 2 diabetic patients

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