Time-Transient Effects of Silver and Copper in the Porous Titanium Dioxide Layer on Antibacterial Properties

Shimabukuro, Masaya; Hiji, Akari; Manaka, Tomoyo; Nozaki, Kosuke; Chen, Peng; Ashida, Maki; Tsutsumi, Yusuke; Nagai, Akiko; Hanawa, Takao

doi:10.3390/jfb11020044

Cited by 20 publications

(15 citation statements)

References 52 publications

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“…MAO easily and selectively incorporates the required elements into the titanium surface owing to the compositional control in the electrolyte. Table 2 summarizes the published articles related to the one-step MAO-based incorporation of antibacterial elements onto the Ti surface [ 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 ]. It should be noted that some researchers have combined MAO and other surface modification processes [ 103 , 104 , 105 , 106 ].…”

Section: Micro-arc Oxidation (Mao)mentioning

confidence: 99%

“…Therefore, the biodegradation behavior must be precisely characterized to understand its antibacterial effect and durability. Our previous studies [ 97 , 102 ] simulated the biodegradation behaviors of Ag-, Cu-, and Zn-incorporated Ti surfaces by immersion in physiological saline for 28 days to investigate the changes in surface composition, chemical states, and antibacterial effects. The surface concentrations of Ag, Cu, and Zn were dramatically decreased by incubation for up to 7 days and remained at slight amounts until 28 days ( Figure 4 a).…”

Section: Time-transient Effects Of Ag Cu and Zn On Their Antibacmentioning

confidence: 99%

“… Changes in the concentration of Ag, Cu, and Zn in the oxide layer ( a ) and antibacterial effects ( b ) before and after incubation in saline for 28 days [ 97 , 102 ]. …”

Section: Figurementioning

confidence: 99%

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Antibacterial Property and Biocompatibility of Silver, Copper, and Zinc in Titanium Dioxide Layers Incorporated by One-Step Micro-Arc Oxidation: A Review

Shimabukuro

2020

Antibiotics

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Titanium (Ti) and its alloys are commonly used in medical devices. However, biomaterial-associated infections such as peri-implantitis and prosthetic joint infections are devastating and threatening complications for patients, dentists, and orthopedists and are easily developed on titanium surfaces. Therefore, this review focuses on the formation of biofilms on implant surfaces, which is the main cause of infections, and one-step micro-arc oxidation (MAO) as a coating technology that can be expected to prevent infections due to the implant. Many researchers have provided sufficient data to prove the efficacy of MAO for preventing the initial stages of biofilm formation on implant surfaces. Silver (Ag), copper (Cu), and zinc (Zn) are well used and are incorporated into the Ti surface by MAO. In this review, the antibacterial properties, cytotoxicity, and durability of these elements on the Ti surface incorporated by one-step MAO will be summarized. This review is aimed at enhancing the importance of the quantitative control of Ag, Cu, and Zn for their use in implant surfaces and the significance of the biodegradation behavior of these elements for the development of antibacterial properties.

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Section: Micro-arc Oxidation (Mao)mentioning

confidence: 99%

Section: Time-transient Effects Of Ag Cu and Zn On Their Antibacmentioning

confidence: 99%

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Antibacterial Property and Biocompatibility of Silver, Copper, and Zinc in Titanium Dioxide Layers Incorporated by One-Step Micro-Arc Oxidation: A Review

Shimabukuro

2020

Antibiotics

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“…In the preparation process, the phase transformation of antibacterial active metals inevitably occurs, such as during electrochemical treatments or powder processing at high temperatures, which may lead to the oxidation of the metal. Shimabukuro et al [186] embedded Cu in the TiO 2 layer on the implant surface using MAO. They found that Cu existed in the form of Cu 2 O and exerted an antibacterial effect.…”

Section: Coppermentioning

confidence: 99%

Toward Bactericidal Enhancement of Additively Manufactured Titanium Implants

et al. 2021

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Implant-associated infections (IAIs) are among the most intractable and costly complications in implant surgery. They can lead to surgery failure, a high economic burden, and a decrease in patient quality of life. This manuscript is devoted to introducing current antimicrobial strategies for additively manufactured (AM) titanium (Ti) implants and fostering a better understanding in order to pave the way for potential modern high-throughput technologies. Most bactericidal strategies rely on implant structure design and surface modification. By means of rational structural design, the performance of AM Ti implants can be improved by maintaining a favorable balance between the mechanical, osteogenic, and antibacterial properties. This subject becomes even more important when working with complex geometries; therefore, it is necessary to select appropriate surface modification techniques, including both topological and chemical modification. Antibacterial active metal and antibiotic coatings are among the most commonly used chemical modifications in AM Ti implants. These surface modifications can successfully inhibit bacterial adhesion and biofilm formation, and bacterial apoptosis, leading to improved antibacterial properties. As a result of certain issues such as drug resistance and cytotoxicity, the development of novel and alternative antimicrobial strategies is urgently required. In this regard, the present review paper provides insights into the enhancement of bactericidal properties in AM Ti implants.

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“…Ionescu et al [ 12 ] have looked to the synergistic antibacterial performance of toothpaste containing nano-hydroxyapatite substituted with metal ions. Shimabukuro et al [ 13 ] have investigated both the durability of the antibacterial effect and the surface change of Ag- and Cu-incorporated porous titanium dioxide (TiO 2 ) layer; silver (Ag) and copper (Cu) have been incorporated into the titanium (Ti) surface to realize their antibacterial properties. Ag- and Cu-incorporated TiO 2 layers were formed by micro-arc oxidation (MAO) treatment using the electrolyte with Ag and Cu ions.…”

mentioning

confidence: 99%