Time trend and regional variability of mortality rate due to ovarian cancer in Brazil: a 15-year analysis

Schoueri, Jean Henri Maselli; Kaufman, Fernando Alves Affonso; Camargo, Celeste Rodovalho Soares de; Sette, Cláudia Vaz de Melo; Adami, Fernando; Figueiredo, Francisco Winter dos Santos

doi:10.1093/pubmed/fdy080

Cited by 3 publications

(3 citation statements)

References 14 publications

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“…It occurs bilaterally in 30-50% of patients, affects women close to 60 years of age, is generally diagnosed late, and results in high lethality. In the context of late diagnosis and high lethality [9], studies on tumor biomarkers are very important for the prevention and early detection of ovarian cancer [3,6], as well as for analyzing social and demographic aspects to track the most vulnerable population and better understand the etiology of ovarian cancer [1,18,19].…”

Section: Discussionmentioning

confidence: 99%

“…Regarding mortality, a study based on the Global Cancer Observatory (GLOBOCAN) database showed that mortality rates vary among different countries due to differences in the Human Development Index (HDI) [2]. According to the National Cancer Institute (INCA), in Brazil, ovarian cancer is considered a gynecologic neoplasm with the lowest chance of cure, because of the challenges in diagnosis and the lack of an appropriate screening method to detect the disease at an early stage [3]. In this context, the discovery of a biomarker considering the histological subtypes of ovarian cancer may help identify individuals at a higher risk and/or detect the disease at an early stage.…”

Section: Introductionmentioning

confidence: 99%

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Social, Genetics and Histopathological Factors Related to Titin (TTN) Gene Mutation and Survival in Women with Ovarian Serous Cystadenocarcinoma: Bioinformatics Analysis

Gomes

Figueiredo

Araújo

et al. 2023

Genes

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Several factors may increase the risk of development of ovarian cancer. In this study, we investigated the relationship between social, genetic, and histopathologic factors in women with ovarian serous cystadenocarcinoma and titin (TTN) mutations, whether the TTN gene mutation may be a predictor, and its impact on mortality and survival in these patients. A total of 585 samples from patients with ovarian serous cystadenocarcinoma were collected from The Cancer Genome Atlas and PanCancer Atlas through the cBioPortal for analysis of social, genetic, and histopathological factors. Logistic regression was used to investigate whether TTN mutation could be a predictor, and the Kaplan–Meier method was applied to analyze survival time. TTN mutation frequency did not differ between age at diagnosis, tumor stage, and race, and was related to increased Buffa hypoxia score (p = 0.004), mutation count (p < 0.0001), Winter hypoxia Score (p = 0.030), nonsynonymous tumor mutation burden (TMB) (p < 0.0001), and reduced microsatellite instability sensor score (p = 0.010). The number of mutations (p < 0.0001) and winter hypoxia score (p = 0.008) were positively associated with TTN mutations, and nonsynonymous TMB (p < 0.0001) proved to be a predictor. Mutated TTN affects the score of genetic variables involved in cancer cell metabolism in ovarian cystadenocarcinoma.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Social, Genetics and Histopathological Factors Related to Titin (TTN) Gene Mutation and Survival in Women with Ovarian Serous Cystadenocarcinoma: Bioinformatics Analysis

Gomes

Figueiredo

Araújo

et al. 2023

Genes

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show abstract

“…(AUGUSTO et al, 2018;FERREIRA et al, 2018;JANOVSKY et al, 2018;LUCIANO et al, 2018;PAIVA;SOUZA, 2018;TEIXEIRA et al, 2018b;ALMEIDA et al, 2019ALMEIDA et al, , 2019BESSA;BONATTO, 2019;HERTZ et al, 2019;SENGER;SANTAREM;GOLDMEIER, 2019). Outra variável muito analisada nas pesquisas foi a região estudada, pois a prevalência de algumas condições e os investimentos em saúde influenciam de forma expressiva nos dados (BOQUETT et al, 2018;FERNANDES et al, 2018;PAVANITTO;MENEZES;NASCIMENTO, 2018;SCHOUERI et al, 2018;TEIXEIRA et al, 2018a;KUPEK, 2018).…”

Section: Estratégias De Pesquisaunclassified

Uso De Dados Do Departamento De Informática Do Sistema Único De Saúde (DATASUS) Em Pesquisas Científicas

Sousa¹,

Stadulni²,

Costa³

2021

Revista Científica Multidisciplinar Núcleo do Conhecimento

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O Departamento de Informática do Sistema Único de Saúde (DATASUS) surgiu como um instrumento responsável por dar suporte em sistemas de informação aos órgãos do Sistema Único de Saúde (SUS), apoiando dessa maneira os processos de planejamento, operação e controle do SUS. Esse estudo teve como objetivo verificar como os dados disponibilizados pelo DATASUS têm sido utilizados em pesquisas científicas. A seleção dos artigos científicos foi realizada por meio de levantamento bibliográfico em periódicos nacionais e internacionais acessíveis via internet na base de dados PubMed. A palavra DATASUS foi utilizada na busca dos artigos. A pesquisa realizada a partir da palavra-chave proposta na base de dados PubMed, para o período entre 01/01/2018 a 01/05/2019 produziu 35 citações. Após a triagem dos artigos, 2 foram excluídos. Foram lidos e analisados 33 artigos completos, destes, 17 foram publicados em periódicos internacionais (51,5%) e 16 (48,4%) em periódicos nacionais. As unidades de análise mais utilizadas foram: óbito em 44,1% dos artigos e internação em 32,3% dos artigos. O DATASUS é um instrumento implementado no SUS há 28 anos e possibilita analisar de forma consistente inúmeros aspectos que envolvem a saúde pública no Brasil, apesar disso, ele não tem sido utilizado efetivamente nos últimos anos.

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Global patterns and temporal trends in ovarian cancer morbidity, mortality, and burden from 1990 to 2019

Mazidimoradi,

Momenimovahed,

Khani

et al. 2023

Oncologie

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Objectives Ovarian cancer (OC) is the deadliest gynecological cancer in the world. Deeper knowledge over time is the basis for global studies to design and implement effective measures to reduce inequalities; this study was conducted to investigate the trend of OC incidence and management in the world from 1990 to 2019. Methods We obtained crude numbers and age-standardized rate (ASRs) of OC annually from the 2019 Global Burden of Disease (GBD) study to examine OC’s morbidity, mortality rates, and disability-adjusted life years (DALYs) based on age group, sociodemographic index (SDI), WHO regions, continents, World Bank regions, and GBD regions from 1990 to 2019 in 204 countries and territories. The relative change (%) and average Annual Percent Change (AAPC) were used to display the epidemiological trend. Results Globally, the number of OC incidents increased from 141,706 in 1990 to 294,422 in 2019. Despite the age-standardized incidence rate (ASIR) in regions with high SDI having a downward trend, these areas recorded the highest incidence cases and ASIR in 2019. Although the World Bank high-income level had the most frequent incidence cases and ASIR, the ASIR in these regions decreased from 1990 to 2019. Among the continents, Europe and America have the highest ASIR but experienced a decreasing trend from 1990 until 2019 in ASIR. The age-standardized mortality rate (ASMR) in the World Bank high-income level experienced a decreasing trend in 1990–2019. In contrast, in the middle, low-middle, and low SDI regions, the death number increased approximately 3.5–4.1 times, and the ASMR had a significant increase from 0.5 in the middle to 0.75 in the low-middle SDI. Globally, the DALY cases of OC rose from 2,732,666 in 1990 to 5,359,737 in 2019; almost doubling. A significant decrease in the DALYs ASR was observed in seven GBD regions. The most pronounced decrease was found in Australia. Conclusions The trend of OC incidence and burden and approximate mortality were stable from 1990 to 2019; especially in lower socioeconomic areas and low-income countries; while the incidence ASR of this cancer in the high SDI regions decreased from 1990 to 2019. The key to reducing OC remains in primary prevention. Approaches such as weight loss, a healthy lifestyle and diet, promoting childbearing and breastfeeding, and recommending the use of oral contraceptives in eligible individuals can have a protective effect against this silent killer.

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Time trend and regional variability of mortality rate due to ovarian cancer in Brazil: a 15-year analysis

Abstract: Although there are oscillations in mortality rates of OC in Brazil and its regions over the period studied, this parameter has remained relatively stable.

Cited by 3 publications

References 14 publications

Social, Genetics and Histopathological Factors Related to Titin (TTN) Gene Mutation and Survival in Women with Ovarian Serous Cystadenocarcinoma: Bioinformatics Analysis

Social, Genetics and Histopathological Factors Related to Titin (TTN) Gene Mutation and Survival in Women with Ovarian Serous Cystadenocarcinoma: Bioinformatics Analysis

Uso De Dados Do Departamento De Informática Do Sistema Único De Saúde (DATASUS) Em Pesquisas Científicas

Global patterns and temporal trends in ovarian cancer morbidity, mortality, and burden from 1990 to 2019

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