Tissue depletion of biotin in chickens and the development of deficiency lesions and the fatty liver and kidney syndrome

Abstract

SUMMARYWithin two weeks of hatching liver reserves of biotin were depleted so that chickens were likely to develop fatty liver and kidney syndrome. However, liver biotin concentrations had to remain low for 3 to 4 weeks before overt deficiency lesions and growth depression were observed. Liver and kidney biotin concentrations were a more sensitive index of biotin intake than circulating concentrations of the vitamin, especially when intake was low.

Effect of Adding Different Levels of Biotinto the Diet in Some Biochemical Characteristics of the Blood Serum of Japanese Quail Exposed to Oxidative Stress

“…From these results, it can be noted that the treatment with biotin led to an increase in the concentration of total protein and albumin, and this proves its role in acting as one of the most important antioxidants (Combs, 2008;A l-Qudah,2010), which was reflected in the health status of the herd and reducing stress. Resulting from oxidation of free radicals represented by an increase in the concentration of total protein and albumin, in addition to the role of biotin in increasing the number of lymphocytes white, which decreased its percentage in the index of the ratio of lymphocytes to heterozygous cells in the factors of adding biotin in this study, and that the significant improvement in the albumin concentration of the biotin treatments in the blood serum It may be due to the improvement of the total protein ratio, as an increase in the total protein concentration in the blood serum indicates an increase in protein synthesis and a decrease in protein catabolism (Patterson et al,1967).As for glucose concentration, it is known that biotin has an important role in maintaining normal levels of glucose in the blood (Bryden ,1991;Volker ,2007), through its work as an co enzymatic companion to carboxylases as it acts as a non-protein group accompanying the enzymes to transport the carboxyl group. Carboxy pyruvate is an enzyme of the Carboxylase group for which biotin acts as an co enzyme companion, and Carboxy pyruvate serves to determine the process of regenerating glucose (Chapman and Cronan,1999).…”