Tissue Distribution of I131 Labeled Human Serum Albumin Following Intravenous Administration

Abstract

Previous studies utilizing I'sl' labeled human serum albumin have revealed that approximately 60 per cent of the total exchangeable albumin of nonedematous subjects is in extravascular locations (1,2

Studies of Iodoalbumin Metabolism. Ii. The Effects of Thyroid Hormone*

“…Once in the circulating blood, albumin is transported across the capillary wall to the interstitial fluid and body cavity fluids. It is probable that the transport of albumin from the interstitial fluid to plasma is almost exclusively via lymphatics rather than by re-entry of blood capillaries (12 (14). Utilizing the fluorescent antibody technique, Gitlin, Landing and Whipple (15) have demonstrated homologous serum albumin intracellularly in a variety of human tissues.…”

The Effect of Large Doses of Desiccated Thyroid on the Distribution and Metabolism of Albumin-I131 in Euthyroid Subjects1

“…One of the highest extravascular-intravascular ratios ever observed in this laboratory was in a patient with myxedema, in whom 73 per cent of the iodinated albumin remaining within the body at distribution equilibrium was in the extravascular spaces (2). The high extravascular albumin content in myxedema may be related to increased skin thickness since it has been shown that skin contains a disproportionately large fraction of the total extravascular albumin (3). It therefore seemed of interest to evaluate whether extravascular-intravascular shifts of serum albumin could be initiated in euthyroid subjects by the administration of large doses of thyroid hormone.…”

Kinetics of movement of iodide, sucrose, inulin and radio‐iodinated serum albumin in the central nervous system and cerebrospinal fluid of the rat

“…injection the brain RISA curve was practically parallel to the plasma curve; the muscle RISA concentration continued to increase during the 24hr. Rothschild, Bauman, Yalow & Berson (1955) studied the RISA levels in muscle for 22 days after i.v. injection and found that the muscle activity increased steadily during the first 5 days and then remained constant.…”