Tissue engineering, 3D-Bioprinting, morphogenesis modelling and simulation of biostructures: Relevance, underpinning biological principles and future trends

Rodríguez, Diego Alejandro Sánchez; Ramos-Murillo, Ana Isabel; Godoy-Silva, Rubén Darío

doi:10.1016/j.bprint.2021.e00171

Cited by 6 publications

(4 citation statements)

References 240 publications

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“…One of the exciting prospects of bioprinting is the ability to print and arrange all the components of a tissue, including cells and matrix materials, in three dimensions to create structures that closely resemble natural tissues [ 112 , 113 ].The precise delivery of living cells with suitable materials in an organized manner, at the right location and in sufficient quantities, within an appropriate environment, is crucial for various emerging technologies [ 63 , 65 , 66 ].…”

Section: Discussionmentioning

confidence: 99%

The Progress in Bioprinting and Its Potential Impact on Health-Related Quality of Life

Yaneva,

Shopova,

Bakova

et al. 2023

Bioengineering

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The intensive development of technologies related to human health in recent years has caused a real revolution. The transition from conventional medicine to personalized medicine, largely driven by bioprinting, is expected to have a significant positive impact on a patient’s quality of life. This article aims to conduct a systematic review of bioprinting’s potential impact on health-related quality of life. A literature search was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive literature search was undertaken using the PubMed, Scopus, Google Scholar, and ScienceDirect databases between 2019 and 2023. We have identified some of the most significant potential benefits of bioprinting to improve the patient’s quality of life: personalized part production; saving millions of lives; reducing rejection risks after transplantation; accelerating the process of skin tissue regeneration; homocellular tissue model generation; precise fabrication process with accurate specifications; and eliminating the need for organs donor, and thus reducing patient waiting time. In addition, these advances in bioprinting have the potential to greatly benefit cancer treatment and other research, offering medical solutions tailored to each individual patient that could increase the patient’s chance of survival and significantly improve their overall well-being. Although some of these advancements are still in the research stage, the encouraging results from scientific studies suggest that they are on the verge of being integrated into personalized patient treatment. The progress in bioprinting has the power to revolutionize medicine and healthcare, promising to have a profound impact on improving the quality of life and potentially transforming the field of medicine and healthcare.

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Section: Discussionmentioning

confidence: 99%

The Progress in Bioprinting and Its Potential Impact on Health-Related Quality of Life

Yaneva,

Shopova,

Bakova

et al. 2023

Bioengineering

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“…The significance of tissue engineering is that it gives the potential that damaged tissues can be replaced with new ones through bioengineering in a laboratory environment and then later implanted within the human body. [5] Tissue engineering, with the help of AM techniques, has shown more favorable solutions to complications found during the traditional tissue engineering process. Traditional tissue engineering techniques include adding regenerative cells to a scaffold containing growth factors and eventually allowing a functional matrix to be formed.…”

Section: Introductionmentioning

confidence: 99%

“…[2] Moreover, a few other notable characteristics of bioprinting include its ability to "adaptability to a traditional, modular or mixed approach" and capacity to print details down to the range of 50-200 μm. [5] Conventional bioprinting techniques usually follow a layer-by-layer manner to construct 3D structures, like extrusion-based, droplet-based, and laser-assisted including digital light processing (DLP) and stereolithography (SLA). [7] There are also some new technologies that do not follow the layer-by-layer method such as volumetric bioprinting (VBP), which is a notable advancement in bioprinting, also known as computed axial lithography (CAL), that enables printing large cm-scaled structures in a considerable short time with high resolution.…”

Section: Introductionmentioning

confidence: 99%

Computational Fluid Dynamics (CFD) Analysis of Bioprinting

Fareez,

Naqvi,

Mahmud

et al. 2024

Adv Healthcare Materials

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The rapid evolution of healthcare and technology has given rise to advancements in the fields of bioprinting, tissue engineering, and regenerative medicine. 3D bioprinting has emerged as an alternative to traditional practices by offering the potential to create functional tissues. Traditional tissue engineering has faced challenges due to irregular cell distribution on scaffolds, limited cell density, and the difficulty of manufacturing patient‐specific tissues, which 3D bioprinting overcomes through layer‐by‐layer fabrication. This has immense significance for addressing organ shortages and enhancing transplant options for the future. 3D printing fully functional organs is a far‐sighted dream; however, the field is moving in the right direction, and research is being done to shorten the gap between the dream and reality. Notably, bioprinting's precision and compatibility with complex geometries have fueled its demand for lab‐grown tissue constructs. Computational Fluid Dynamics (CFD), a cornerstone of engineering, finds relevance in diverse sectors, including bioengineering. Its cost‐effectiveness and accurate simulation capabilities have drawn attention to its application in bioprinting research. CFD plays a pivotal role in optimizing 3D bioprinting by testing parameters like shear stress, diffusivity, and cell viability. This reduces the need for repetitive experiments, curbing costs and time. CFD simulations also enable the analysis of flow behaviors and material deformation under stress, aiding in material selection and bioprinter nozzle design. This review delves into recent applications of CFD in 3D bioprinting, shedding light on its potential to enhance the performance of this technology. Through this integration, CFD offers a pathway to advancing bioprinting, thus contributing to the evolution of regenerative medicine and healthcare.This article is protected by copyright. All rights reserved

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“…Biomaterial development should primarily focus on and deal with some key issues (conforming degradation to tissue development and ensuring adequate mechanical properties while obtaining rheological properties needed for the manufacturing process), structure design (including vascularization of the structure), and system integration (integration of multiple cells, materials, and manufacturing processes in a sterile and controlled environment) [ 27 , 28 , 29 ]. The major prospect of bioprinting is the ability to print and pattern all the components that comprise a tissue (cells and matrix materials) in three dimensions to generate structures similar to tissues [ 30 ]. Also, printing tissue analogue constructs is vital for some emerging technologies that require the delivery of living cells with appropriate material in a defined and organized manner, at the right location, in sufficient numbers, and within the right environment [ 29 , 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

(Bio)printing in Personalized Medicine—Opportunities and Potential Benefits

et al. 2023

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The global development of technologies now enters areas related to human health, with a transition from conventional to personalized medicine that is based to a significant extent on (bio)printing. The goal of this article is to review some of the published scientific literature and to highlight the importance and potential benefits of using 3D (bio)printing techniques in contemporary personalized medicine and also to offer future perspectives in this research field. The article is prepared according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Web of Science, PubMed, Scopus, Google Scholar, and ScienceDirect databases were used in the literature search. Six authors independently performed the search, study selection, and data extraction. This review focuses on 3D bio(printing) in personalized medicine and provides a classification of 3D bio(printing) benefits in several categories: overcoming the shortage of organs for transplantation, elimination of problems due to the difference between sexes in organ transplantation, reducing the cases of rejection of transplanted organs, enhancing the survival of patients with transplantation, drug research and development, elimination of genetic/congenital defects in tissues and organs, and surgery planning and medical training for young doctors. In particular, we highlight the benefits of each 3D bio(printing) applications included along with the associated scientific reports from recent literature. In addition, we present an overview of some of the challenges that need to be overcome in the applications of 3D bioprinting in personalized medicine. The reviewed articles lead to the conclusion that bioprinting may be adopted as a revolution in the development of personalized, medicine and it has a huge potential in the near future to become a gold standard in future healthcare in the world.

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Tissue engineering, 3D-Bioprinting, morphogenesis modelling and simulation of biostructures: Relevance, underpinning biological principles and future trends

Cited by 6 publications

References 240 publications

The Progress in Bioprinting and Its Potential Impact on Health-Related Quality of Life

The Progress in Bioprinting and Its Potential Impact on Health-Related Quality of Life

Computational Fluid Dynamics (CFD) Analysis of Bioprinting

(Bio)printing in Personalized Medicine—Opportunities and Potential Benefits

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