Tissue engineering for bone regeneration and osseointegration in the oral cavity

Pilipchuk, Sophia P.; Plonka, Alexandra B.; Monje, Alberto; Taut, Andrei D.; Lanis, Alejandro; Kang, Benjamin; Giannobile, William V.

doi:10.1016/j.dental.2015.01.006

Cited by 180 publications

(177 citation statements)

References 191 publications

(146 reference statements)

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“…There have only been a limited number of studies, which use triple combination (stem cells, growth factors, and scaffolds) in host tissues, which ultimately increases the success rate of osteogenic regeneration, which is supported by the results of the current study (31)(32)(33).…”

Section: Discussionsupporting

confidence: 64%

In Vitro Cultivation, Characterization and Osteogenic Differentiation of Stem Cells from Human Exfoliated Deciduous Teeth on 3D Printed Polylactic Acid Scaffolds

İslam

Mammadov

Kendirci

et al. 2017

Iran Red Crescent Med J

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Section: Discussionsupporting

confidence: 64%

In Vitro Cultivation, Characterization and Osteogenic Differentiation of Stem Cells from Human Exfoliated Deciduous Teeth on 3D Printed Polylactic Acid Scaffolds

İslam

Mammadov

Kendirci

et al. 2017

Iran Red Crescent Med J

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“…For example, partial dental tissue repair techniques involve specialised dental materials with uncertain effectiveness and durability, while high-tech dental implants are used for tooth replacement (Esposito et al, 2013;Fron Chabouis et al, 2013). These materials are often used in conjunction with growth factors and molecules to enhance the regenerative capacity of dental and periodontal tissues (Pilipchuk et al, 2015). Recent advances in tissue engineering and regenerative…”

Section: Introductionmentioning

confidence: 99%

Stem cell-based approaches in dentistry

Mitsiadis

Orsini

Jiménez-Rojo

2015

eCM

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Repair of dental pulp and periodontal lesions remains a major clinical challenge. Classical dental treatments require the use of specialised tissue-adapted materials with still questionable efficacy and durability. Stem cell-based therapeutic approaches could offer an attractive alternative in dentistry since they can promise physiologically improved structural and functional outcomes. These therapies necessitate a sufficient number of specific stem cell populations for implantation. Dental mesenchymal stem cells can be easily isolated and are amenable to in vitro expansion while retaining their stemness. In vivo studies realised in small and large animals have evidenced the potential of dental mesenchymal stem cells to promote pulp and periodontal regeneration, but have also underlined new important challenges. The homogeneity of stem cell populations and their quality control, the delivery method, the quality of the regenerated dental tissues and their integration to the host tissue are some of the key challenges. The use of bioactive scaffolds that can elicit effective tissue repair response, through activation and mobilisation of endogenous stem cell populations, constitutes another emerging therapeutic strategy. Finally, the use of stem cells and induced pluripotent cells for the regeneration of entire teeth represents a novel promising alternative to dental implant treatment after tooth loss. In this mini-review, we present the currently applied techniques in restorative dentistry and the various attempts that are made to bridge gaps in knowledge regarding treatment strategies by translating basic stem cell research into the dental practice.

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“…In the past two decades, tissue engineering by bone regeneration has become an alternative method used to overcome the shortcomings of conventional bone defect treatments [1][2][3][4]. In tissue engineering, the application of biomaterials is increasing, and the development of porous media, the so-called scaffold, is an advanced multidisciplinary research effort meant to meet the tissue engineering demand for regenerating tissues [5,6].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Porous Hydroxyapatite and Alginate Composite Scaffolds for Bone Tissue Engineering

2018

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Objective: To prepare and characterize composite scaffolds of a hydroxyapatite (HA) and an alginate having high viscosity. Materials and Methods:HA powder was synthesized using wet chemical precipitation, the alginate powder was extracted from the Sargassum duplicatum seaweed, and the HA/alginate composite scaffolds were prepared by freeze-drying. X-ray diffraction and Fourier transform infrared techniques were utilized to characterize the HA and alginate, and electron microscopy was used to evaluate the HA and the HA/alginate composite scaffolds. The HA/alginate composite scaffold obtained from the commercially available HA and alginate powders were employed as a comparison.Results: Synthesized HAs were identified as the HA phase, which contained absorbed water, phosphate, and carbonate groups. The extracted alginate contained the carboxyl, cyclic ether and hydroxyl groups. The scaffolds prepared from the HA and alginate mixture were three-dimensional and containing interconnected pores with a diameter ranging from 150 to 300 µm and pore walls of a composite construction. Conclusion:A three-dimensional scaffold was produced using a freeze-drying method from a composite of HA and the high viscosity alginate solution. The scaffold was highly porous and showed interconnected pores, with a diameter ranging from 150 to 300 µm.

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Tissue engineering for bone regeneration and osseointegration in the oral cavity

Cited by 180 publications

References 191 publications

In Vitro Cultivation, Characterization and Osteogenic Differentiation of Stem Cells from Human Exfoliated Deciduous Teeth on 3D Printed Polylactic Acid Scaffolds

In Vitro Cultivation, Characterization and Osteogenic Differentiation of Stem Cells from Human Exfoliated Deciduous Teeth on 3D Printed Polylactic Acid Scaffolds

Stem cell-based approaches in dentistry

Preparation and Characterization of Porous Hydroxyapatite and Alginate Composite Scaffolds for Bone Tissue Engineering

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