Tissue ingrowth and differentiation in the bone-harvest chamber in the presence of cobalt-chromium-alloy and high-density-polyethylene particles.

Goodman, Stuart B.; Aspenberg, Per; Song, Yong; Knoblich, Gunther; Huie, Phil; Regula, Donald; Lidgren, Lars

doi:10.2106/00004623-199507000-00008

Cited by 88 publications

(75 citation statements)

References 24 publications

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“…However, it is possible that metal particles are more harmful than polyethylene particles, due to their shape and smaller size (Pazzaglia et al 1987). CoCr particles are known to be toxic (Haynes et al 1993) and conducive to infection (Corder0 et al 1994), induce proliferation of macrophages (Howie 1990), damage macrophages (Rae 1975) and fibroblastic cells (Maloney et al 1993), reduce the amount of bone (Goodman et al 1995), and cause malignant tumors in rats (Lewis and Sunderman 1996). The health risk from metal release has been debated.…”

Section: Discussionmentioning

confidence: 99%

Metal release from total hip articulations in vitro: Substantial from CoCr/CoCr, negligible from CoCr/PE and alumina/PE

Saikko¹,

Nevalainen

Revitzer

et al. 1998

Acta Orthopaedica Scandinavica

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Section: Discussionmentioning

confidence: 99%

Metal release from total hip articulations in vitro: Substantial from CoCr/CoCr, negligible from CoCr/PE and alumina/PE

Saikko¹,

Nevalainen

Revitzer

et al. 1998

Acta Orthopaedica Scandinavica

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“…However, as shown in Table, the amounts and sizes of particles have varied between the different studies (Howie et al 1988, Goodman 1994, Bobyn et al 1995, Dowd et al 1995, Frökjaer et al 1995, Goodman et al 1995, 1999, Kraemer et al 1995, Allen et al 1996, Aspenberg and Herbertsson 1996, Shanbhag et al 1997, Van Der Vis et al 1997, Kim et al 1998, Frökjaer et al 1999, Lalor et al 1999, Brooks et al 2000, Rahbek et al 2000, 2001, Bechtold et al 2001, Bi et al 2001b, Sundfeldt et al 2002. The time of introduction of the particles and the design of the studies also varied greatly.…”

Section: Particle Diseasementioning

confidence: 99%

Aseptic loosening, not only a question of wear: A review of different theories

et al. 2006

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“…Patients' median OHS (using the 48-point OHS) improved from 26 (range, [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] preoperatively to 46 (range, [35][36][37][38][39][40][41][42][43][44][45][46][47][48], and UCLA score improved from 5 (range, 2-8) to 8 (range, 4-10) at latest review (paired t-test p \ 0.001 for both). There was no difference in median [35][36][37][38][39][40][41][42][43][44][45][46][47][48] or in the median postoperative UCLA scores between males (8; range, 5-10) and females (8; range, 4-10) (Mann-Whitney U p = 0.293 and p = 0.115, respectively).…”

Section: Survivorship and Hip Scoresmentioning

confidence: 99%

“…The metal debris in BMHR may come from the wear of the bearing surface or the corrosion of the BMHR taper junction. Cobalt, chromium, and titanium have been shown to affect bone turnover in animal studies by decreasing bone formation and inducing resorption [20,24], and all three metal ions can be released from the BMHR device. However, all patients with osteolysis in our series had normal blood metal ion levels; and pseudotumors have been found common in well-functioning low-wearing MoM hips with no osteolysis [22,33].…”

Section: Study Limitationsmentioning

confidence: 99%

Frequent Femoral Neck Osteolysis With Birmingham Mid-head Resection Resurfacing Arthroplasty in Young Patients

Asaad

Hart

Khoo

et al. 2015

Clinical Orthopaedics &Amp; Related Research

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Background Mid-head resection total hip resurfacing arthroplasty was promoted as an alternative to traditional total hip resurfacing for patients with poor femoral head bone quality or abnormal femoral head morphology, because those patients are at high risk of failure with traditional total hip resurfacing. It is a large-headed metal-onmetal device that uses a short, bone-conserving stem. Good performance of the implant has been reported at short-term followup, but no information on the implant performance in the mid-or long-term is available. Questions/purposes In this study, we report (1) on the mid-term implant survivorship and hip scores in a single nondesigner surgeon series. Because of the occurrence of femoral neck osteolysis and pseudotumor in a subgroup of patients, we also investigated the following: (2) Were there any preoperative parameters that are associated with osteolysis? (3) Could we differentiate the osteolysis group from the others on the basis of implant component sizes, positions, and radiologic parameters? (4) Could we differentiate the osteolysis group from the others on the basis of metal ion levels? Methods Between 2006 and 2011, one surgeon performed a total of 49 Birmingham Mid-head Resection total hip resurfacing arthroplasties in 47 patients. The general indications for this procedure were young patients who were considered suitable for hip resurfacing arthroplasty but had avascular necrosis, large cysts, or severe deformity of the femoral head. Clinical followup including Oxford Hip Score (OHS) and UCLA hip scores were available preoperatively and at a mean of 6 years (range, 3-8 years) on all patients (100%), radiographic followup on 45 of 47 (96%), MRIs on 18 (38%), and metal ion levels on 37 (79%). Mean age at surgery was 50 years. Spearman's correlation was used to test the association between femoral neck osteolysis and preoperative parameters, implant component sizes and positions, and blood metal ion levels. Results We found 100% survival. Patients' median OHS was 46 of 48 (range, 35-48) and UCLA 8 of 10 (range, 4-10). However, 16% of the hips (seven of 45) demonstrated osteolysis in the femoral neck. Of the preoperative parameters, the osteolysis was associated with low weight (r = À0.337, p = 0.031) and to a lesser degree with female sex (r = 0.275, p = 0.067). Radiologically, the osteolysis was strongly associated with the presence of a

show abstract

Tissue ingrowth and differentiation in the bone-harvest chamber in the presence of cobalt-chromium-alloy and high-density-polyethylene particles.

Cited by 88 publications

References 24 publications

Metal release from total hip articulations in vitro: Substantial from CoCr/CoCr, negligible from CoCr/PE and alumina/PE

Metal release from total hip articulations in vitro: Substantial from CoCr/CoCr, negligible from CoCr/PE and alumina/PE

Aseptic loosening, not only a question of wear: A review of different theories

Frequent Femoral Neck Osteolysis With Birmingham Mid-head Resection Resurfacing Arthroplasty in Young Patients

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