Tissue-protective effects of fullerenol C60(OH)24 and amifostine in irradiated rats

Trajković, Sanja; Dobrić, Silva; Jacević, Vesna; Dragojević-Simić, Viktorija; Milovanović, Zoran; Đorđević, Aleksandar

doi:10.1016/j.colsurfb.2007.01.005

Cited by 148 publications

(70 citation statements)

References 10 publications

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“…Fullerenol treatment significantly reduced the level of GGT and elevated the level of SOD in irradiated cells, suggesting the redox homeostasis effect and ROS scavenging activity of fullerenol [28]. Fullerenol of C 60 (OH) 24 was found with great radioprotective effects on the spleen, small intestine, and lung in rats [29]. It was previously reported that C 60 nanoparticles, prepared by mechanical-milling in liquid media without adding any polarorganic solvent, could protect the liver in a dose-dependent manner against CCl 4 acute toxicities in rats by scavenging large numbers of radicals [30].…”

Section: Anti-oxidative Activitymentioning

confidence: 90%

Fullerenes as unique nanopharmaceuticals for disease treatment

Liang

2010

Sci. China Chem.

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As unique nanoparticles, fullerenes have attracted much attention due to their unparalleled physical, chemical and biological properties. Various functionalized fullerenes with OH, NH 2 , COOH, and peptide modifications were developed. It summarized the biological activities of fullerenes derivatives in cancer therapy with high efficiency and low toxicity, as reactive oxygen species scavenger and lipid peroxidation inhibitor, to inhibit human immunodeficiency virus and to suppress bacteria and microbial at low concentration. In addition, the mechanism for fullerene to enter cells and biodistribution of fullerene in vivo was also discussed. This research focuses on the current understanding of fullerenes-based nanomaterials in the potential clinical application as well as biological mechanism of fullerenes and its derivatives in disease therapy. fullerene, nanoparticle, nanomedicine, clinical application, biological effect

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Section: Anti-oxidative Activitymentioning

confidence: 90%

Fullerenes as unique nanopharmaceuticals for disease treatment

Liang

2010

Sci. China Chem.

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“…These tissue distribution studies suggest that apart from the bone marrow, salivary gland and kidneys, the heart might also benefit from cytoprotection provided by amifostine treatment prior to cardiotoxic radio-and chemotherapy. In our previous experiment in which general radioprotective efficacy of amifostine was examined in rats subjected to whole body irradiation (WBI, absolutely lethal dose of X-rays), it was shown that amifostine significantly protected rats and increased their survival comparing to the unprotected animals Trajkovic et al, 2007). Moreover, a mean cardiac damage (MCD) score, obtained by histopathological analysis, in amifostine-pretreated rats was significantly reduced compared with unprotected animals, on both days 7 and 28 after WBI.…”

Section: Amifostinementioning

confidence: 98%

Doxorubicin-Induced Oxidative Injury of Cardiomyocytes - Do We Have Right Strategies for Prevention?

Torres¹,

Dragojevic-Simic²

2012

Cardiotoxicity of Oncologic Treatments

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“…In relation to fullerenol radioprotectivity, importance must be placed on its hemato-and tissue-protective effects. So far, the tissue protective effect has mainly been confi rmed on the spleen, small intestine and lung tissue [105].…”

Section: Fullerenol In Vivo Activitymentioning

confidence: 99%

Bioimpact of Carbon Nanomaterials

Djordjević

Injac

Mrdjanović

et al. 2013

Advanced Carbon Materials and Technology

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The unique size-dependent properties of carbon nanomaterials (CNMs)-graphene, nanotubes (CNTs) and fullerenes-make them very attractive for diagnostic and therapeutic application. This chapter presents possible application of CNMs. Graphene with extraordinary chemical and physical properties has already revealed a great number of potential applications such as environmental toxic material removal, drug delivery, tissue engineering, and fl uorescence-based biomolecular sensing. The CNT derivatives have many interesting properties which make them potentially useful in a living system as biosensors, bioelectronic devices based on enzyme-nanotube or antibody-nanotube conjugates, chemotherapeutic agents, hyperthermia therapy and immunotherapy agents, agent in treatment of central nervous system disorders, and tissue engineering agent. Fullerene C 60 derivatives have been used as: drug and gene delivery vectors, magnetic resonance imaging agents, radio protectors, antioxidants, HIV-1 protease inhibitors, antigenotoxic agents, and phototherapy agents. Fullerenols are polyhydroxylated derivatives of fullerene (C 60 (OH)n) with remarkable antioxidant, xenobiotic-protective, radioprotective, nanodrug and endohedral gadolinium carrier properties.

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Tissue-protective effects of fullerenol C60(OH)24 and amifostine in irradiated rats

Cited by 148 publications

References 10 publications

Fullerenes as unique nanopharmaceuticals for disease treatment

Fullerenes as unique nanopharmaceuticals for disease treatment

Doxorubicin-Induced Oxidative Injury of Cardiomyocytes - Do We Have Right Strategies for Prevention?

Bioimpact of Carbon Nanomaterials

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