Tissue reactions to collagen scaffolds in the oral mucosa and skin of rats: Environmental and mechanical factors

Collagen-Gelatin Scaffold Impregnated with bFGF Accelerates Palatal Wound Healing of Palatal Mucosa in Dogs

“…It has been reported that collagen scaffolds implanted in oral mucoperiosteal defects improve wound healing and reduce contracture and scar tissue formation [3,[14][15][16]. Recently we succeeded in developing a novel scaffold that can provide sustained release of bFGF [17].…”

Collagen- vs. Gelatine-Based Biomaterials and Their Biocompatibility: Review and Perspectives

“…Measuring the intensities and duration of the immune responses against implanted biomaterials is important for biocompatibility evaluation. The tissue response towards implanted biomaterials (also called the foreign body reaction) is influenced by morphology and composition of the biomaterial and the place where biomaterial is implanted (Ye et al, 2010;Jansen et al, 2008;Wang et al, 2008). Inflammation reaction is manifested by secretion of large amount of antibodies (secreting B cells and T cells with cytotoxic activity) and cytokines, in presence of foreign materials (as scaffolds) or pathogens.…”

Penetration effect of prostaglandin E2 gel on oral mucosa of rats

“…18 To be able to make the small dosage of PGE 2 , which is 25 µg and could penetrate into mucosa layer, the application of PGE 2 gel could be done in sequence, 3 times of 0, 2, and 4 hours. The active accumulation could continue to penetrate into deeper mucosa tissue until the alveolar bones.…”