Tissue-Specific Accumulation and Antioxidant Defenses in Flounder (Paralichthys olivaceus) Juveniles Experimentally Exposed to Methylmercury

Ren, Zhonghua; Lü, Jinhu; Dou, Shuping; Zhou, Dayan; Cui, Wenting; Lv, Zhenbo; Cao, Liang

doi:10.1007/s00244-020-00775-2

Cited by 5 publications

(3 citation statements)

References 55 publications

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“…Moreover, flounder possesses antioxidant defensive responses to mercury. A recent study shows that activities of antioxidants in the flounder muscle are enhanced by mercury, even if its exposure dose is low 22 . Shark muscle is also a natural source of antioxidants 23 .…”

Section: Discussionmentioning

confidence: 99%

Prenatal antioxidant-enriched and pro-oxidant-contained food, IL4 and IL13 pathway genes, and cord blood IgE

Chen

Lee

et al. 2022

Sci Rep

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Prenatal oxidative balance might influence cord blood IgE (cIgE) levels. We aimed to explore if certain prenatal dietary sources of antioxidants and pro-oxidants are associated with cIgE elevation and if they interact with IL4 and IL13 pathway genes. A structured questionnaire was completed during the third trimester of pregnancy for 1107 full-term newborns. Surveyed antioxidant-enriched food included fish, shellfish, and fruit, whereas surveyed pro-oxidant-contained food included fried fish sticks and canned fish. Cord blood was collected for measuring cIgE levels and genotyping IL13 rs1800925, rs20541, rs848, IL4 rs2243250, and STAT6 rs324011. Fairly lean fish consumption showed protection against cIgE elevation (odds ratio [OR] 0.66; 95% CI 0.49–0.90) in the whole sample, while daily fruit (OR 0.46; 95% CI 0.27–0.79) and ≥ monthly canned fish (OR 2.81; 95% CI 1.24–6.36) exhibited associations only in genetically susceptible babies. A prenatal food protective index, comprising any fairly lean fish, daily fruit, and the absence of any canned fish, exerted dose–response protection against cIgE elevation in babies carrying the IL13 rs20541 GA or AA genotype (P for trend < 0.0001; P for interaction = 0.004). We concluded that prenatal antioxidant-enriched and pro-oxidant-contained food consumption may influence cIgE, especially in genetically susceptible babies.

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Section: Discussionmentioning

confidence: 99%

Prenatal antioxidant-enriched and pro-oxidant-contained food, IL4 and IL13 pathway genes, and cord blood IgE

Chen

Lee

et al. 2022

Sci Rep

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“…In the environment, mercu-ry is released by both natural and anthropogenic sources https://www.epa.gov/international-cooperation/ mercury-emissions-global-context. Organic mercury in the environment is of critical concern because of its highest toxicity (Ren et al, 2020). The toxicity caused by HgCl2 is related to the production of intracellular reactive oxygen species (ROS), Oxidative stress can induce genotoxicity caused due exposure to toxic compounds in various organisms (Trivedi et al, 2022;Kumar et al, 2022a;Kumar et al, 2022b).…”

Section: Introductionmentioning

confidence: 99%

“…

Print), 2231-5209 (Online) journals.ansfoundation.orgResearch Article which initiate oxidative stress and cellular damage (Trivedi et al, 2022). Estimation of oxidative stress parameters such as GSH and LPO reflects ill effects of mercury toxicity (Trivedi et al, 2022;Ren et al, 2020).

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confidence: 99%

Toxicological manifestations in gills, liver, kidney and muscles of Channa punctatus exposed to mercuric chloride

Kumar,

Zaveria,

Abhishek

et al. 2023

JANS

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Aquatic regimes are exposed to a variety of pollutants that are mainly released by anthropogenic activities. Mercuric chloride (HgCl2) pose serious hazards to freshwater fish resource for its toxicity and long persistence. It is also a threat to humans who consume fish as a food resource. This study aimed to determine the consequences of acute exposure to HgCl2 in the freshwater food fish Channa punctatus (Bloch, 1973). The acute study of 96 hours was composed of three groups (in triplicates), having ten fish in each group which includes group I (control), group II (0.112 mg/l of HgCl2) and group III (0.224 mg/l of HgCl2). Results showed induction in reactive oxygen species (ROS) level in erythrocytes of group III (22159 ± 258.036). The biomarkers of oxidative stress, glutathione reduced (GSH) and lipid peroxidase (LPO) showed significant (p < 0.05) decrement and increment in their activity, respectively, in gills, liver, kidney and muscle tissues of the fish treated with HgCl2. Further, micronuclei (MN) and nuclear abnormalities (NAs) were formed in the erythrocytes of the fish of groups II and III, revealing DNA damage, hence showing genotoxicity. Histopathological studies in sample tissues of HgCl2 treated group demonstrated irreversible tissue injuries and anomalies. Thus, the findings from the study demonstrate that biological stress is induced in fish because of acute exposure to HgCl2, leading to health impairment

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From molecular endpoints to modeling longer-term effects in fish embryos exposed to the elutriate from Doce River

Yamamoto

Souza²,

Paula³

et al. 2022

Science of The Total Environment

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Tissue-Specific Accumulation and Antioxidant Defenses in Flounder (Paralichthys olivaceus) Juveniles Experimentally Exposed to Methylmercury

Cited by 5 publications

References 55 publications

Prenatal antioxidant-enriched and pro-oxidant-contained food, IL4 and IL13 pathway genes, and cord blood IgE

Prenatal antioxidant-enriched and pro-oxidant-contained food, IL4 and IL13 pathway genes, and cord blood IgE

Toxicological manifestations in gills, liver, kidney and muscles of Channa punctatus exposed to mercuric chloride

From molecular endpoints to modeling longer-term effects in fish embryos exposed to the elutriate from Doce River

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