Tissue specificity of 8-prenylnaringenin: Protection from ovariectomy induced bone loss with minimal trophic effects on the uterus

Hümpel, M.; Isaksson, P.; Schaefer, Olaf; Kaufmann, Ulrike; Ciana, Paolo; Maggi, Adriana; Schleuning, Wolf‐Dieter

doi:10.1016/j.jsbmb.2005.05.009

Cited by 57 publications

(53 citation statements)

References 25 publications

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“…It is characterized by an uncoupling between bone resorption and bone formation. In some circumstances, osteoporosis may be due solely to either reduced bone formation or Ming /Zhou /Cheng /Ma /Chen Pharmacology 2011;88: [33][34][35][36][37][38][39][40][41][42][43] 34 increased bone resorption. The disequilibrium of the remodeling parameters leads to low bone density and an increased risk of osteoporotic fractures [3] .…”

Section: Introductionmentioning

confidence: 99%

Osthol, a Coumarin Isolated from Common Cnidium Fruit, Enhances the Differentiation and Maturation of Osteoblasts in vitro

Ming¹,

Zhou²,

Cheng³

et al. 2011

Pharmacology

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The effect of osthol on osteoblasts was investigated in primary osteoblastic cells isolated from newborn Wistar rats. Osthol was supplemented into cultured medium at 10^–7, 10^–6, 10^–5 and 10^–4 mol/l, respectively. No stimulating effect was found on cell proliferation, but 10^–5 mol/l osthol caused a significant increase in alkaline phosphatase (ALP) activity. Osteogenic differentiation markers were examined over a period of time at this concentration, and compared with control cells that were not supplemented with osthol. The results showed that the ALP activity, osteocalcin secretion and calcium deposition level in cells treated with osthol were 1.52, 2.74 and 2.0 times higher, respectively, than in the control cells. Results of ALP histochemical staining and mineralized bone nodule assays both showed that the number and area achieved in osthol-treated cells were 1.53-fold higher than in control cells. The gene expression of the growth and transcription factors basic fibroblast growth factor, insulin-like growth factor I, bone morphogenetic protein 2 (BMP-2), runt-related gene 2 (Runx-2) and osterix, which are associated with bone development, were also investigated. The increase in mRNA expression was 1.94, 1.74, 1.68, 1.83 and 2.31 times, respectively, higher compared to the control. Furthermore, osthol increased the protein expression of p38 mitogen-activated protein kinase (MAPK) and type I collagen. p38MAPK protein and collagen in osthol-treated cells were 1.42 and 1.58 times higher in osthol-treated cells compared to the control. The results of these studies support the conclusion that osthol significantly enhances the osteogenic differentiation of cultured osteoblasts. The results also indicated that osthol could stimulate the osteoblastic differentiation of rat calvarial osteoblast cultures by the BMP-2/p38MAPK/Runx-2/osterix pathway and that osthol may be used as an important compound in the development of new antiosteoporosis drugs.

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Section: Introductionmentioning

confidence: 99%

Osthol, a Coumarin Isolated from Common Cnidium Fruit, Enhances the Differentiation and Maturation of Osteoblasts in vitro

Ming¹,

Zhou²,

Cheng³

et al. 2011

Pharmacology

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“…This fact acquires a more relevant importance in the light of recent tenable evidences, as above cited, reported from some authors concerning the absence of negative side effects by some phytoestrogens (particularly genistein, 8-prenylnaringenin, reveratrol and red clover extract) on the tropism of various organs commonly targeted by estrogens (Burdette et al, 2002;Duffy et al, 2007;Eason et al, 2005;Gallo et al, 2006;Garcia-Perez et al, 2006;Hümpel et al, 2005;Lian et al, 2001;Limer & Speirs, 2004;Murray et al, 2003;Whitsett & Lamartiniere, 2006;Wu et al, 2002).…”

Section: Resultsmentioning

confidence: 82%

Role of Phytoestrogen Ferutinin in Preventing/Recovering Bone Loss: Results from Experimental Ovariectomized Rat Models

Palumbo¹,

Cavani²,

Bertoni³

et al. 2012

Osteoporosis

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“…Humpel a kol. (2005) testovali in vivo vliv 8-prenylnaringeninu na schopnost bránit ztrátě hustoty kostní hmoty po odebrání vaječníků krysím samičkám a ukazuje se, že 8-prenylnaringenin působí proti ztrátě kostní hmoty, pomáhá proti úbytku hmotnosti tkáně vagíny a působí proti nežádou-cím změnám vaginální sliznice (Humpel et al, 2005). cially the saturated ones, are able to inhibit these enzymes (Steffen et al, 2008).…”

Section: Estrogenní a Antiosteoporotické účInkyunclassified

“…Suh et al (2013) demonstrated the ability of xanthohumol to inhibit the activator NF-κB, which plays among other things a main role in the genesis of osteoclasts (Suh et al, 2013). Humpel et al (2005) tested the in vivo potential of 8-prenylnaringenin to prevent the loss of bone tissue density in female rats after removal of the ovaries. It seems that 8-prenylnaringenin successfully prevents the loss of bone tissue, defeats the decrease of vaginal tissue density and works against unwanted changes in the vaginal mucous membrane (Humpel et al, 2005).…”

Section: Oestrogenic and Antiosteoporotic Effectsmentioning

confidence: 99%

Prenylated Flavonoids as Valuable Biologically Active Compounds from Hops

et al. 2017

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Prenylované fl avonoidy jako cenné biologicky aktivní látky chmeleKlíčová slova : chmel, biologická aktivita, xanthohumol, 8-prenylnaringenin, zdravotní účinky ■ 1 ÚVOD Chmel otáčivý (Humulus lupulus L.) z čeledi konopovitých je rostlina, která je využívaná k lékařským účelům více než 2000 let (Koetter a Biendl, 2010). Již ve starověku léčitelé používali chmel při léčbě malomocenství, zápachu nohou, proti zácpě a při čištění krve (Karabin et al., 2015). V 11. století popsal arabský léčitel Mesue protizánětlivé účinky chmele (Koetter a Biendl, 2010). Později, roku 1158, německá abatyše a bylinářka Hildegarda z Bingenu nepřímo potvrdila antimikrobiální vlastnosti chmele, když doporučila přidává-ní chmele do nápojů za účelem prodloužení jejich skladovatelnosti. Od 13. století se většina historických spisů zmiňuje převážně o využití chmele pro pivovarské účely. Dochovala se i řada lékařských dokumentů z tohoto období a v jednom z nejcennějších, rukopisu z 15. století "Garden of Health", je popsán pozitivní účinek chmele při léčbě ušní infekce (Karabin et al., 2015). Hop cones contain a number of important compounds, which are frequently used in the brewing industry. Recently, an increasing interest has been raised in using hops also for other purposes, particularly in the pharmaceutical industry. The group of prenylated fl avonoids belongs to compounds with pharmaceutical potential. They display anticancer, cardiovascular, antioxidant, antimicrobial, antiinfl ammatory and oestrogenic effects, which have a positive impact on human health. This study presents the current knowledge about the biological effects exploitable in the pharmaceutical industry. Die Hopfendolden enthalten eine Reihe von bedeutenden Verbindungen, die häufi g in der Brauindustrie angewandt sind, zur Zeit nimmt die Interesse über ihre Anwendung zu den anderen Zwecken zu, ins besonders in der pharmazeutischen Industrie. Unter den Verbindungen des Hopfens mit dem pharmazeutischen Potenzial gehört auch die Gruppe von prenylierten Flavonoiden, die eine Reihe von bedeutenden Wirkungen auf die menschliche Gesundheit, ins besondere Antikarzionogen-, Kardiovaskulär-, Antioxidant-, Antimikrobial-, Antientzündug-und Östrogenwirkungen ausweisen. In dem übersichtlichen Artikel werden die zeitgenössischen Kenntnisse über einzelnen biologischen Wirkungen, die potenziale Ausnutzung in der pharmazeutischen Industrie haben, angeführt.

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Tissue specificity of 8-prenylnaringenin: Protection from ovariectomy induced bone loss with minimal trophic effects on the uterus

Cited by 57 publications

References 25 publications

Osthol, a Coumarin Isolated from Common Cnidium Fruit, Enhances the Differentiation and Maturation of Osteoblasts in vitro

Osthol, a Coumarin Isolated from Common Cnidium Fruit, Enhances the Differentiation and Maturation of Osteoblasts in vitro

Role of Phytoestrogen Ferutinin in Preventing/Recovering Bone Loss: Results from Experimental Ovariectomized Rat Models

Prenylated Flavonoids as Valuable Biologically Active Compounds from Hops

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