Titanium hypersensitivity causing painful intra‐abdominal oedema after staple‐fixed inguinal hernia repair

Hofmann, Silke; Plett, Maria; Jansen, Stefan; Thomas, Peter A.; Thölken, Karisa Farias Miksza

doi:10.1111/cod.12985

Cited by 6 publications

(9 citation statements)

References 9 publications

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“…There is growing evidence that titanium hypersensitivity from medical devices is not as rare as previously considered. [1][2][3][4][5][6][7][8] In the present case, medical history, histopathology showing an inflammatory pseudotumor with giant cells containing black pigment compatible with titanium 10…”

Section: Discussionmentioning

confidence: 99%

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Inflammatory lung pseudotumor possibly related to titanium hypersensitivity

et al. 2023

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Section: Discussionmentioning

confidence: 99%

“…Nevertheless, it has been recognized as a potential cause of complications following surgical procedures, related to titanium hypersensitivity, [1][2][3][4][5][6][7][8] as in the present case.…”

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confidence: 95%

Inflammatory lung pseudotumor possibly related to titanium hypersensitivity

et al. 2023

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“…Symptoms of hypersensitivity reaction include pain, joint effusion, swelling or allergic dermatitis (localized or systemic), changes in the oral mucosa and mucosal immune system connected with the presence of dental implants or prosthetic work [59], delayed bone healing, implant instability, and ultimately the aseptic failure of implants [60][61][62]. Due to previously described serious symptoms and the increasing incidence of hypersensitivity reactions to the implant materials in the population in recent years [63][64][65][66][67][68][69][70], this study is aimed at demonstrating the benefits of the MELISA® test for the minimization or complete elimination of health problems in patients with confirmed hypersensitivity to metals. The hypothesis of this study is that compliance with the health recommendations based on the results of MELISA® test will improve patients' symptoms induced by metal hypersensitivity.…”

Section: Introductionmentioning

confidence: 99%

Titanium and Other Metal Hypersensitivity Diagnosed by MELISA® Test: Follow-Up Study

Vrbová

Podzimek

Himmlová

et al. 2021

BioMed Research International

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This study is aimed at proving the clinical benefit of the MELISA® test in the minimization or complete elimination of health problems in patients with confirmed hypersensitivity to metals used for tissue replacements. A group of 305 patients aged 20-75 years with previously proven metal hypersensitivity (initial MELISA® test), mainly to titanium and then to another fifteen metals, was chosen from the database at the Institute of Dental Medicine. From these patients, a final group of 42 patients agreed to participate in the study, 35 of which were female and 7 were male. The patients completed a special questionnaire aimed at information regarding change of health status from their last visit and determining whether the results of the initial MELISA® test and recommendations based on it were beneficial for patients or not. They were clinically examined, and peripheral blood samples were taken to perform follow-up MELISA® tests. Questionnaire data was processed, and the follow-up MELISA® test results were compared with the results of the initial MELISA® tests. For statistical analysis, the Fisher’s exact test and paired T -test were used. Thirty-two patients reported that they followed the recommendations based on the results of the initial MELISA® tests, and of these, 30 patients (94%) confirmed significant health improvement. Six patients did not follow the recommendation, and from these, only one patient reported an improvement in his health problems. By comparison of the initial and follow-up MELISA® test results, it can be stated that the hypersensitivity to the given metal decreased or disappeared after the therapeutic interventions performed based on the initial MELISA® test results. The evaluation of the data obtained from patients in this study confirmed a significant clinical benefit of MELISA® test.

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“…For medical applications, especially dispersion ceramics like alumina toughened zirconia (ATZ) ceramics as well as ZTA (zirconia toughened alumina) are reliable materials, since they ideally combine a good biocompatibility (inertness) with a high wear resistance, exceptional hardness, high mechanical strength, and slow hydrothermal aging [17][18][19]. In addition to their outstanding biomechanical properties, the fast and stable ingrowth of host tissue into superficial implant structures is advantageous to inhibit intolerances, hypersensitivities, or allergic reactions, and to promote good osseointegration [20][21][22]. Crucial for this purpose is the availability of a defined pore gradient as a combination, for example from nano-, microand macrostructures which might combine complex microstructures and fine features on the nanoscale [23].…”

Section: Introductionmentioning

confidence: 99%

Process Development for Additive Manufacturing of Alumina Toughened Zirconia for 3D Structures by Means of Two-Photon Absorption Technique

et al. 2021

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Additive manufacturing is well established for plastics and metals, and it gets more and more implemented in a variety of industrial processes. Beside these well-established material platforms, additive manufacturing processes are highly interesting for ceramics, especially regarding resource conservation and for the production of complex three-dimensional shapes and structures with specific feature sizes in the µm and mm range with high accuracy. The usage of ceramics in 3D printing is, however, just at the beginning of a technical implementation in a continuously and fast rising field of research and development. The flexible fabrication of highly complex and precise 3D structures by means of light-induced photopolymerization that are difficult to realize using traditional ceramic fabrication methods such as casting and machining is of high importance. Generally, slurry-based ceramic 3D printing technologies involve liquid or semi-liquid polymeric systems dispersed with ceramic particles as feedstock (inks or pastes), depending on the solid loading and viscosity of the system. This paper includes all types of photo-curable polymer-ceramic-mixtures (feedstock), while demonstrating our own work on 3D printed alumina toughened zirconia based ceramic slurries with light induced polymerization on the basis of two-photon absorption (TPA) for the first time. As a proven exemplary on cuboids with varying edge length and double pyramids in the µm-range we state that real 3D micro-stereolithographic fabrication of ceramic products will be generally possible in the near future by means of TPA. This technology enables the fabrication of 3D structures with high accuracy in comparison to ceramic technologies that apply single-photon excitation. In sum, our work is intended to contribute to the fundamental development of this technology for the representation of oxide-ceramic components (proof-of-principle) and helps to exploit the high potential of additive processes in the field of bio-ceramics in the medium to long-term future.

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Titanium hypersensitivity causing painful intra‐abdominal oedema after staple‐fixed inguinal hernia repair

Cited by 6 publications

References 9 publications

Inflammatory lung pseudotumor possibly related to titanium hypersensitivity

Inflammatory lung pseudotumor possibly related to titanium hypersensitivity

Titanium and Other Metal Hypersensitivity Diagnosed by MELISA® Test: Follow-Up Study

Process Development for Additive Manufacturing of Alumina Toughened Zirconia for 3D Structures by Means of Two-Photon Absorption Technique

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