Titelbild: Directed 1D Assembly of a Ring‐Shaped Inorganic Nanocluster Templated by an Organic Rigid‐Rod Molecule: An Inorganic/Organic Polypseudorotaxane (Angew. Chem. 11/2008)

The development of biomolecular fiber materials with imaging ability has become more and more useful for biological applications. In this work, cationic conjugated polymers (CCPs) were used to construct inherent fluorescent microfibers with natural biological macromolecules (DNA and histone proteins) through the interfacial polyelectrolyte complexation (IPC) procedure. Isothermal titration microcalorimetry results show that the driving forces for fiber formation are electrostatic and hydrophobic interactions, as well as the release of counterions and bound water molecules. Color-encoded IPC fibers were also obtained based on the coassembly of DNA, histone proteins, and blue-, green-, or red-(RGB-) emissive CCPs by tuning the fluorescence resonance energy-transfer among the CCPs at a single excitation wavelength. The fibers could encapsulate GFP-coded Escherichia coli BL21, and the expression of GFP proteins was successfully regulated by the external environment of the fibers. These multi-colored fibers show a great potential in biomedical applications, such as biosensor, delivery, and release of biological molecules and tissue engineering.

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Multi‐Colored Fibers by Self‐Assembly of DNA, Histone Proteins, and Cationic Conjugated Polymers

Wang

Liu

Wang

et al. 2013

Angewandte Chemie

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Multi‐Colored Fibers by Self‐Assembly of DNA, Histone Proteins, and Cationic Conjugated Polymers

et al. 2013

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The development of biomolecular fiber materials with imaging ability has become more and more useful for biological applications. In this work, cationic conjugated polymers (CCPs) were used to construct inherent fluorescent microfibers with natural biological macromolecules (DNA and histone proteins) through the interfacial polyelectrolyte complexation (IPC) procedure. Isothermal titration microcalorimetry results show that the driving forces for fiber formation are electrostatic and hydrophobic interactions, as well as the release of counterions and bound water molecules. Color-encoded IPC fibers were also obtained based on the co-assembly of DNA, histone proteins, and blue-, green-, or red- (RGB-) emissive CCPs by tuning the fluorescence resonance energy-transfer among the CCPs at a single excitation wavelength. The fibers could encapsulate GFP-coded Escherichia coli BL21, and the expression of GFP proteins was successfully regulated by the external environment of the fibers. These multi-colored fibers show a great potential in biomedical applications, such as biosensor, delivery, and release of biological molecules and tissue engineering.

show abstract

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Titelbild: Directed 1D Assembly of a Ring‐Shaped Inorganic Nanocluster Templated by an Organic Rigid‐Rod Molecule: An Inorganic/Organic Polypseudorotaxane (Angew. Chem. 11/2008)

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Multi‐Colored Fibers by Self‐Assembly of DNA, Histone Proteins, and Cationic Conjugated Polymers

Multi‐Colored Fibers by Self‐Assembly of DNA, Histone Proteins, and Cationic Conjugated Polymers

Multi‐Colored Fibers by Self‐Assembly of DNA, Histone Proteins, and Cationic Conjugated Polymers

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