TLRs as pharmacological targets for plant-derived compounds in infectious and inflammatory diseases

Liu, Xin; Zheng, Jie; Zhou, Hong

doi:10.1016/j.intimp.2011.04.027

Cited by 21 publications

(15 citation statements)

References 61 publications

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“…The current study identified the expression and modulation of 4 TLRs by CPE, including cell surface localized TLR2, TLR4, TLR10, and nucleic acids sensing TLR3. Biologically active compounds derived from plant extracts can act as agonists or antagonists for TLRs (Liu et al 2011). Previous findings reported by suggested TLR2 as a possible agonist for CPE in bovine blood.…”

Section: Discussionmentioning

confidence: 93%

Microarray analysis of the effect of Cowpea (Vigna unguiculata) phenolic extract in bovine peripheral blood

Adjei‐Fremah

Jackai

Schimmel

et al. 2016

Journal of Applied Animal Research

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Section: Discussionmentioning

confidence: 93%

Microarray analysis of the effect of Cowpea (Vigna unguiculata) phenolic extract in bovine peripheral blood

Adjei‐Fremah

Jackai

Schimmel

et al. 2016

Journal of Applied Animal Research

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“…MMPs have important role in inflammation, tumor invasion and metastasis (Gialeli et al, 2011;Watanabe, 2010;Bulbule et al, 2011). Spearmint oil diminished the expression of MMP-9 in lung tissues of rat in vivo (Liu et al, 2011a). Therefore, anti-tumor and anti-inflammatory effects of spearmint may be in part due (as a result of) to its inhibitory effects on MMP-2/MMP-9 activity.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the anti-inflammatory effect of Mentha piperita against acute and chronic inflammation has been detected (Atta and Alkofahi, 1998). Furthermore, spearmint oil diminished the expression of MMP-9 in lung tissues of rat in vivo (Liu et al, 2011a). The existing therapeutic methods for fibrosarcoma have not been very successful (Vello et al, 2011;Grivas et al, 2010;Okuno et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Down regulation of matrix metalloproteinases by spearmint extract in Wehi-164 cells

Hajighasemi¹,

Hashemi²

2012

J. Med. Plants Res.

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Tumor invasion and metastasis are the main causes of cancer death. Matrix metalloproteinases (MMPs) are endopeptidases which degredate the extracellular matrix proteins. MMPs have an important role in tumor progression and metastasis. Fibrosarcoma has been recognized as a highly metastatic cancer which its current therapeutic methods have not been very successful. Medicinal plants are widely used in treatment of cancers. Spearmint is a herb with well known anti-tumor activities. In the present study, the effect of hydro extract of spearmint on MMP-2/9 activities in Wehi-164 fibrosarcoma cells has been evaluated in vitro. Wehi-164 cells were cultured in Roswell Park Memorial Institute (RPMI) medium with 10% fetal bovine serum (FBS). Then the cells at logarithmic growth phase were incubated with different concentrations of hydro extract of spearmint (0.1 to 10 mg/ml) in the presence or absence of phorbol myristate acetate (PMA) (25 ng/ml) for 24, 48 and 72 h. The MMP-2/MMP-9 activity in conditioned medium was evaluated by gelatin zymography. Spearmint aqueous extract significantly reduced the MMP-2 and PMA-induced MMP-9 activity in fibrosarcoma Wehi-164 cells dose dependently. The aqueous extract of spearmint showed inhibitory effect on MMP-2/MMP-9 activity in Wehi-164 fibrosarcoma cells. So, the anti-tumor effects of spearmint may be in part due to its inhibitory effects on MMP-2/MMP-9 activity. Evaluation of effective component (s) in the spearmint extract with anti-MMP activity and their mechanism of action could be useful in designing novel natural MMP inhibitors.

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“…[6][7][8][9][10][11][12][13] SsnB, therefore, is a promising lead for the development of selective TLR antagonist for inammation control. But the low content of SsnB in plants hampered further studies, which attracted us to develop efficient and practical synthetic methods to prepare SsnB.…”

mentioning

confidence: 99%

Total synthesis of Sparstolonin B, a potent anti-inflammatory agent

Wang

et al. 2015

RSC Adv.

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Two concise routes for the first total synthesis of Sparstolonin B (SsnB) have been described. The synthesis of SsnB could be accomplished in 5 and 6 steps with 40% and 38% overall yield, respectively. The rhodium-catalysed oxidative coupling of benzoic acid with internal alkyne was used in both strategies to construct the core structure of SsnB.Sparstolonin B (SsnB) is the rst novel bioactive natural small molecule, isolated from a Chinese herb, Sparganium stoloniferum, by Liang and coworkers, which selectively blocks toll-like receptors 2 (TLR2) and TLR4 mediated inammatory signalling by inhibiting the recruitment of MyD88 to the Toll/Il-1 receptor homologue domains of TLR2 and TLR4.

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TLRs as pharmacological targets for plant-derived compounds in infectious and inflammatory diseases

Cited by 21 publications

References 61 publications

Microarray analysis of the effect of Cowpea (Vigna unguiculata) phenolic extract in bovine peripheral blood

Microarray analysis of the effect of Cowpea (Vigna unguiculata) phenolic extract in bovine peripheral blood

Down regulation of matrix metalloproteinases by spearmint extract in Wehi-164 cells

Total synthesis of Sparstolonin B, a potent anti-inflammatory agent

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