To Assess the Magnitude of Oxidative Stress and Antioxidant Defense in Preeclampsia

Abstract

Preeclampsia is a multifactorial disease. Recent studies show that free radical induced endothelial injury may be a factor in pathogenesis of preeclampsia and that a biochemical imbalance occurs with an increase of oxidative stress, lipoperoxidation a nd deficient antioxidants. AIMS AND OBJECTIVESTo evaluate parameters of oxidative stress and antioxidant defense in preeclampsia and thereby find any aetiological correlation. MATERIALS AND METHODSStudy was carried on pregnant and non-pregnant women placed in four groups. This study was done to assess Malondialdehyde (MDA), as marker of oxidative stress and Total Antioxidant Capacity (TAC) measured by Ferric Reducing Ability of Plasma (FRAP) in normal pregnancy and preeclampsia and comparing with non-pregnant females. RESULTS Studyshows rise in MDA level highest in severe preeclampsia (192.8) followed by mild preeclampsia (151.8) than in normal pregnancy (105.9), and non-pregnant (95.8) showing significant increase in levels of MDA (p<0.0001) in preeclamptic patients. TAC measured by FRAP significantly highest in severe preeclampsia (1725.6) followed by mild preeclampsia (1507) than in normal pregnancy (1203.3) and although there was increase in TAC in normal pregnant compared to non-pregnant (1173.7), increase was statistically insignificant. CONCLUSIONPreeclampsia shows markedly increased oxidative stress as evidenced by significantly increased levels of malondialdehyde. There was strong correlation between total antioxidant capacity with severity of preeclampsia.

Difference of Frap Levels Between Preeclamptic and Normotensive Women: A Cross-Sectional Analysis from a Tertiary Care Hospital, Pakistan

“…It can lead to eclampsia if not promptly treated. Pre-eclampsia and eclampsia are greatly associated with maternal mortality and poor pregnancy outcomes 14 . The present study showed that 40 (13.0%) women in our study were pre-eclamptic while 269 (87%) were normotensive.…”

Relationship between serum selenium deficiency and preeclampsia among pregnant women at the Rivers State university teaching hospital, Port Harcourt, Nigeria

“…A biochemical imbalance between the production of endogenous antioxidants and the production of free radicals is thought to occur in pregnant women with preeclampsia. This imbalance will lead to an increase in oxidative stress, lipid lipoperoxidation, superoxide anion radicals, and a deficiency of anti-oxidants [10]. If this generated oxidative stress overwhelms the natural protective antioxidant mechanism in the body, there will be an increase in trophoblastic turnover and subsequent release of harmful trophoblastic debris into the maternal circulation [11,12].…”