To Compare the Efficacy of C-Reactive Protein and Total Leucocyte Count as Markers for Monitoring the Course of Odontogenic Space Infections

Bali, Rishi; Sharma, Parveen; Ghanghas, Priya; Gupta, Niti; Tiwari, Jay Dutt; Singh, Abhiroop; Sapra, Nitin; Goyal, Disha

doi:10.1007/s12663-016-0978-3

Cited by 10 publications

(9 citation statements)

References 17 publications

(21 reference statements)

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“…This was contrary to the present study where all the patients had elevated levels of CRP as well as TLC but there was variation in ESR in few patients. 7 Bagul R et al and Seppänen L et al in their studies have observed that the levels of CRP and WBC count were increased in the first visit of the patient presenting with maxillofacial odontogenic infection but it subsequently decreased in the follow-up visits following surgical and medical management. They did not observe any superiority in CRP as compared to WBC count.…”

Section: Discussionmentioning

confidence: 95%

Role of C-reactive Protein, Total Leukocyte count and Erythrocyte Sedimentation Rate as a Diagnostic and Prognostic Indicator in Maxillofacial Infections

Beena¹,

Thomas²,

Bhargava³

et al. 2021

ijocd

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Purpose: The aim of this study was to evaluate the role of C-reactive protein (CRP), Total Leukocyte Count(TLC) and Erythrocyte Sedimentation Rate (ESR) levels as diagnostic and prognostic indicators in patientsdiagnosed with maxillofacial odontogenic infections.Materials and Methods: A prospective study was done among 30 patients with maxillofacial odontogenicinfections. Blood samples were collected at 3 intervals to detect the level of the study parameters followedby incision and drainage for all the patients under Local anesthesia.Results: The mean CRP, TLC and ESR levels gradually reduced on 5th post-operative day as compared today 1 and 3 suggestive of resolution of the infectious state.Conclusion: We conclude that CRP is required only in selective cases of maxillofacial infection wheremonitoring under intensive care will be required, else TLC alone is sufficient to indicate the presence ofinfection along with adequate medical and surgical care.

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Section: Discussionmentioning

confidence: 95%

Role of C-reactive Protein, Total Leukocyte count and Erythrocyte Sedimentation Rate as a Diagnostic and Prognostic Indicator in Maxillofacial Infections

Beena¹,

Thomas²,

Bhargava³

et al. 2021

ijocd

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“…23 Conversely, a recent study showed that CRP level has a more consistent relationship with the clinical severity of the infection than with the leucocyte count. 24 Sierra-Diaz et al 25 used a flow cytometry method to investigate the expression of TREM-1 in urine samples and to compare sTREM-1 levels between UTI and non-UTI samples. They detected TREM-1 expression in both the UTI and non-UTI group, but the levels were significantly higher in the UTI group.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Value of Plasma Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Children with Urinary Tract Infections

Tursun

Alpcan

Özsoy

et al. 2021

Journal of Pediatric Infectious Diseases

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Objective The aim of the present study was to evaluate the diagnostic value of soluble triggering receptor on myeloid cells-1 as a novel marker for diagnosis of childhood urinary tract infections (UTI). Methods This study enrolled 30 pediatric patients diagnosed with acute febrile UTIs; 30 healthy children were included as the control group. The blood samples from the patients and healthy controls were collected for a soluble triggering receptor on myeloid cells-1 (sTREM-1) test. Results The study group was composed of 9 males and 21 females, and the mean age of the study population was 6.6 ± 3.2 (range = 1–14) years. sTREM-1 levels were significantly higher in UTI patients than in the controls (592 ± 323 vs. 490 ± 299 pg/mL, p = 0.04). The receiver operating curve analysis revealed a cut-off value of soluble triggering receptor expressed on myeloid cells-1 of 514 ng/mL (area under the curve = 0.562). When the cut-off value was taken 514 pg/mL, soluble triggering receptor expressed on myeloid cells-1 had a sensitivity of 57% and a specificity of 50% for the diagnosis of UTI. Conclusion The present study revealed that plasma sTREM-1 level may be elevated in UTI and may therefore serve as a useful predictive tool for the diagnosis of UTI.

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“…Computed tomography and ultrasound imaging are used in the diagnosis and surgical managementof severe spreading infections (20). In in-patient care of severe infections, clinical examination can be complemented with determination of leukocyte count and serum C-reactive protein (CRP) level (21).…”

Section: Diagnosis Of Acute Dental Infectionsmentioning

confidence: 99%

Treatment of acute dental infections

Parikka¹,

Norppa²,

Välimaa³

et al. 2019

Tidende

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Antimicrobial resistance is globally a growing public health threat. Constrained and appropriately targeted use of antibiotics in health care could slow down the development of antibiotic resistance. Dentists are responsible for a substantial proportion of all antibiotic prescriptions, thus it is important that dentists know optimal principles and practices of using antibiotics. In Nordic countries, national guidelines have an important role as a source of up to date knowledge and expert opinion on treatment of dental infections including the use of antibiotics. The Nordic guidelines highlight that antibiotics should be prescribed only with strict indications and the use of broad-spectrum antibiotics should be avoided. At the same time, it should be kept in mind that common, localised dental infections may occasionally develop into severe life-threatening infections. Whenever antibiotic treatment is considered in addition to surgical drainage it should be started an hour before the procedure to avoid spread of the infection when manipulating infected tissues. It is essential that dentists can identify the patients with systemic infection or increased infection risk. Antibiotics are needed in severe infections and for patients with increased risk of infection complications, but primarily, acute dental infections are always treated by efficient drainage and elimination of the infection focus. KEY POINTS • Acute dental infections should primarily be treated by drainage and removal of the infection focus • Antibiotics should only be prescribed if there are signs of spreading infection and in suspicion of systemic infection or when local infection is judged not to heal with local treatment alone • Although the Nordic guidelines differ in some details they share the common feature that the base for treatment of dental infections is Pencillin V • Unnecessary use of antibiotics should be avoided because of the growing problem of antibiotic resistance

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To Compare the Efficacy of C-Reactive Protein and Total Leucocyte Count as Markers for Monitoring the Course of Odontogenic Space Infections

Abstract: CRP displayed a more consistent relation with clinical severity of the infection than TLC. Hence it could be more reliably employed to judge the progress in a patient with OSI.

Cited by 10 publications

References 17 publications

Role of C-reactive Protein, Total Leukocyte count and Erythrocyte Sedimentation Rate as a Diagnostic and Prognostic Indicator in Maxillofacial Infections

Role of C-reactive Protein, Total Leukocyte count and Erythrocyte Sedimentation Rate as a Diagnostic and Prognostic Indicator in Maxillofacial Infections

Diagnostic Value of Plasma Soluble Triggering Receptor Expressed on Myeloid Cells-1 in Children with Urinary Tract Infections

Treatment of acute dental infections

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