To Glue or Not to Glue? Analysis of Fibrin Glue for Split-thickness Skin Graft Fixation

Abstract

Background: Split-thickness skin grafting (STSG) is a commonly used tool in the plastic surgeon’s reconstructive armamentarium. Fibrin glue (FG) consists of a combination of clotting factors and thrombin whose key properties include adherence and hemostasis. This preliminary study aimed to assess clinical outcomes and cost of FG for STSG fixation in a general wound reconstruction. Methods: A retrospective review was conducted in all patients undergoing STSG placement by a single surgeon (JPF) from January 2016 to March 2018. Twenty patients were identified and matched by wound location and wound size. Patients were then divided into 2 groups based on the method of STSG fixation: FG (n = 10) or suture only (SO) (n = 10). Results: In patients with FG fixation, we observed trends of decreased adjusted operative times (34.9 versus 49.4 minutes, P = 0.612), a similar length of stay (2.8 versus 3.5 days, P = 0.306), and liberation from the use of negative pressure wound therapy (0 versus 10 wounds, P < 0.0001). There were no observed differences between the 2 groups in terms of graft-related complications at 180 days (1 complication FG versus 0 complications SO). Time to 100% graft take was also not different (20.2 versus 29.4 days, P = 0.405). Additionally, total direct cost ($16,542 FG versus $24,266 SO; P = 0.545) and total charges ($120,336 FG versus $183,750 SO; P = 0.496) were not statistically different between the FG and SO groups. Conclusions: In this preliminary comparative assessment, FG for STSG fixation has shown no difference in clinical outcomes to SO fixation, trends of decreased operative time, and afforded complete liberation from negative pressure wound therapy dressings.

Fibrin glues — the current state of knowledge

“…Physicians from a center in Nottingham applied fibrin for removal of hair cyst from the sacrococcygeal region (pilonidal cyst). After two rounds of curettage, the method was found 97% effective [9,26,[30][31][32][33][34][35][36].…”

Dopamine based adhesive nano-coatings on extracellular matrix (ECM) based grafts for enhanced host–graft interfacing affinity

“…Existing biomaterials studied for grafts' or devices' adhesives or glues [22][23][24][25][26][27][28][29][30] covered proteins such as fibrin, 25 gelatin, 31,32 and albumin, 33 polysaccharides 34,35 such as dextran and chitosan and synthetic polymers such as poly (ethylene glycol) (PEG) and [36][37][38] polyurethanes (PU), 39 which are biocompatible with sufficient mechanical strength. Moreover, adhesives should be capable of adhering to surrounding tissues by chemical bonds, interpenetration or physical linkage such as hydrogen bonds.…”

Fibrin Glue and Autologous Split-Thickness Skin Graft after Facial Skin Cancer Resection

“…Biologic fibrin glues have been applied to support skin graft survival since World War II [10,11]. Since early reports, multiple studies have shown that fibrin glues can reduce operative times, hematoma risk, need for negativepressure wound therapy and bolsters, with equivalent graft survival rates [12][13][14][15]. Herein, we describe the successful use of biologic fibrin glue with split-thickness skin graft reconstruction of a cutaneous facial defect.…”