2005
DOI: 10.1016/j.brainresbull.2004.11.006
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Tooth-pulp-evoked rostral spinal trigeminal nucleus neuron activity is inhibited by conditioning sciatic nerve stimulation in the rat: possible role of 5-HT3 receptor mediated GABAergic inhibition

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Cited by 13 publications
(8 citation statements)
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“…These findings provide clues regarding the novel functions of 5-HT3R. To cite an example from the oral areas, 5-HT3R was reported to be involved in tooth-pulp-evoked Sp5 neuronal excitation8283 and gustatory nerve activation83. In fact, in our study, strong 5-HT3AR expression was observed in the Sp5ODM (the former) and NTS (the latter).…”
Section: Discussionsupporting
confidence: 54%
“…These findings provide clues regarding the novel functions of 5-HT3R. To cite an example from the oral areas, 5-HT3R was reported to be involved in tooth-pulp-evoked Sp5 neuronal excitation8283 and gustatory nerve activation83. In fact, in our study, strong 5-HT3AR expression was observed in the Sp5ODM (the former) and NTS (the latter).…”
Section: Discussionsupporting
confidence: 54%
“…This effect was completely blocked by co‐administration of bicuculline, indicating the 5‐HT3 receptor‐mediated release of GABA in the STN and the involvement of this neurotransmitter in the inhibitory action of phenylbiguanide . In turn, intravenously or microiontophoretically applied tropisetron reduced the sciatic nerve stimulation‐induced inhibition of tooth‐pulp electro stimulation‐evoked discharges of the STN neurons; a similar effect was produced by iontophoretic injection of bicuculline …”
Section: Discussionmentioning
confidence: 79%
“…28 In turn, intravenously or microiontophoretically applied tropisetron reduced the sciatic nerve stimulation-induced inhibition of tooth-pulp electro stimulation-evoked discharges of the STN neurons; a similar effect was produced by iontophoretic injection of bicuculline. 29 These observations imply that 5-HT3 receptor blockade may either, at best, not affect central nociceptive processing or, at worst, increase transmission of pain signals. The last possibility among other things may be a reason why headache is one of the most common side effects associated with the use of setrons.…”
Section: Discussionmentioning
confidence: 99%
“…Such disinhibition activates glutamatergic followed by serotonergic neurons in the nucleus raphe magunus (NRM) (the PAG-NRM-trigeminal pathway) [56]. In addition, in vitro resveratrol upregulates ion currents stimulated through 5-HT 3 receptors [58], and conditioning stimulation of peripheral nerve induced 5-HT 3 receptor-mediated GABAergic inhibition on the excitability of SpVc neurons responding to noxious stimulation [59,60]. Together, these findings indicate that excitatory synaptic transmission of the SpVc is suppressed by resveratrol via activation of GABAergic activity mediated by 5-HT 3 receptor (Fig.…”
Section: Central Mechanismmentioning
confidence: 99%