Topical Antibacterial Agents

Nielson, Colton; Hsu, Sylvia; Motaparthi, Kiran

doi:10.1016/b978-0-323-61211-1.00041-3

Cited by 7 publications

(5 citation statements)

References 247 publications

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“…Moreover, the authors observed its efficiency in diminishing hyperpigmentation. The effectiveness of azelaic acid in decreasing hyperpigmentation has been confirmed in many studies and for this reason the acid is widely used in cosmetology and dermatology 25–28 . Moreover, some studies have reported the role of this compound in the reduction of post‐inflammatory hyperpigmentation, or hyperpigmentation caused by phototoxic reactions 29,30 .…”

Section: Discussionmentioning

confidence: 87%

“…The effectiveness of azelaic acid in decreasing hyperpigmentation has been confirmed in many studies and for this reason the acid is widely used in cosmetology and dermatology. [25][26][27][28] Moreover, some studies have reported the role of this compound in the reduction of post-inflammatory hyperpigmentation, or hyperpigmentation caused by phototoxic reactions. 29,30 In turn, PA is an alpha-hydroxy acid used mainly for skin exfoliation and lightening.…”

Section: (Cheek)mentioning

confidence: 99%

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Clinical evaluation of anti‐aging effects of combined therapy—Azelaic acid, phytic acid, and vitamin C applied layer by layer in females with Fitzpatrick skin types II and III

Markiewicz‐Tomczyk

Budzisz

Erkiert‐Polguj

2022

J of Cosmetic Dermatology

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Introduction Vitamins C, E, and A and substances of plant origin, including azelaic acid and phytic acid are frequently used in cosmetic preparations to counteract oxidative stress and negative effects of free radicals. The aim of the study was to evaluate a novel combined therapy consisting of azelaic acid, ascorbic acid, and phytic acid applied layer on layer. Methods Twenty study participants received a series of eight treatments performed every 7 days. Twenty percent azelaic acid and then 30% phytic acid were applied to the entire face, while 40% l‐ascorbic acid only on the left side. The preparations were applied layer by layer. Skin parameters were measured before the series of treatments (T0), after the series of eight treatments (T1–8 weeks), and 1 month after the end of the treatment (T2–12 weeks). Results The application of two and three active compounds resulted in a significant improvement in erythema and hyperpigmentation both on the forehead and the cheeks, however, more pronounced effects were observed when all the three active compounds were used. Both applied types of treatment considerably increased skin moisture. All the participants (100%) were satisfied with the effects of the treatment. A majority of them reported an improvement in skin hydration, firmness, and elasticity, more uniform skin tone and a reduction of skin redness and wrinkles. Conclusions Topical application of these active compounds resulted in improvement of skin elasticity and flexibility, reduction of wrinkles, hyperpigmentation, erythema, and telangiectasia as well as amelioration of skin tone.

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Section: Discussionmentioning

confidence: 87%

Section: (Cheek)mentioning

confidence: 99%

Clinical evaluation of anti‐aging effects of combined therapy—Azelaic acid, phytic acid, and vitamin C applied layer by layer in females with Fitzpatrick skin types II and III

Markiewicz‐Tomczyk

Budzisz

Erkiert‐Polguj

2022

J of Cosmetic Dermatology

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“…Finally, in special populations, i.e., in persons pregnant or lactating, it is not advisable to administer clindamycin. Concerning oral administration, unless the necessity for its use outweighs the risks, oral clindamycin in the long term is cautioned against and topical clindamycin (i.e., for acne treatment) is not suggested as (i) clindamycin can be found in breast milk and (ii) safety considerations of clindamycin for dermatologic use when pregnant or breastfeeding have not been holistically described [ 71 , 77 , 82 , 83 ]. Overall, it is pertinent to acknowledge that clindamycin is a suitable treatment option for a range of dermatologic indications, but also that safety, efficacy, and individual patient histories must be considered when prescribing clindamycin in accordance with evidence based medicine.…”

Section: Efficacy and Use Of Clindamycin In Dermatologic Diseasementioning

confidence: 99%

Scientific Rationale and Clinical Basis for Clindamycin Use in the Treatment of Dermatologic Disease

Armillei,

Lomakin,

Del Rosso

et al. 2024

Antibiotics

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Clindamycin is a highly effective antibiotic of the lincosamide class. It has been widely used for decades to treat a range of skin and soft tissue infections in dermatology and medicine. Clindamycin is commonly prescribed for acne vulgaris, with current practice standards utilizing fixed-combination topicals containing clindamycin that prevent Cutibacterium acnes growth and reduce inflammation associated with acne lesion formation. Certain clinical presentations of folliculitis, rosacea, staphylococcal infections, and hidradenitis suppurativa are also responsive to clindamycin, demonstrating its suitability and versatility as a treatment option. This review describes the use of clindamycin in dermatological practice, the mechanism of protein synthesis inhibition by clindamycin at the level of the bacterial ribosome, and clindamycin’s anti-inflammatory properties with a focus on its ability to ameliorate inflammation in acne. A comparison of the dermatologic indications for similarly utilized antibiotics, like the tetracycline class antibiotics, is also presented. Finally, this review addresses both the trends and mechanisms for clindamycin and antibiotic resistance, as well as the current clinical evidence in support of the continued, targeted use of clindamycin in dermatology.

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“…Microbial resistance is found to be settled in prolonged treatment, being associated as well with skin reactions like erythema, scaling, dryness which will further influence the patient adherence. The efficacy of the proposed treatment may be compromised in the case of antibiotics like erythromycin or nadifloxacin [ 303 , 304 ]. For erythromycin, a study of Ochiuz and Hortolomei, revealed the importance of choosing the appropriate S/CoS mixture in the formulation study.…”

Section: Microemulsions In a New Vision For An Optimized Acne Thermentioning

confidence: 99%

Foray into Concepts of Design and Evaluation of Microemulsions as a Modern Approach for Topical Applications in Acne Pathology

et al. 2020

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With a fascinating complexity, governed by multiple physiological processes, the skin is considered a mantle with protective functions which during lifetime are frequently impaired, triggering dermatologic disorders. As one of the most prevalent dermatologic conditions worldwide, characterized by a complex pathogenesis and a high recurrence, acne can affect the patient’s quality of life. Smart topical vehicles represent a good option in the treatment of a versatile skin condition. By surpassing the stratum corneum known for diffusional resistance, a superior topical bioavailability can be obtained at the affected place. In this direction, the literature study presents microemulsions as a part of a condensed group of modern formulations. Microemulsions are appreciated for their superior profile in matters of drug delivery, especially for challenging substances with hydrophilic or lipophilic structures. Formulated as transparent and thermodynamically stable systems, using simplified methods of preparation, microemulsions have a simple and clear appearance. Their unique structures can be explained as a function of the formulation parameters which were found to be the mainstay of a targeted therapy.

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Topical Antibacterial Agents

Cited by 7 publications

References 247 publications

Clinical evaluation of anti‐aging effects of combined therapy—Azelaic acid, phytic acid, and vitamin C applied layer by layer in females with Fitzpatrick skin types II and III

Clinical evaluation of anti‐aging effects of combined therapy—Azelaic acid, phytic acid, and vitamin C applied layer by layer in females with Fitzpatrick skin types II and III

Scientific Rationale and Clinical Basis for Clindamycin Use in the Treatment of Dermatologic Disease

Foray into Concepts of Design and Evaluation of Microemulsions as a Modern Approach for Topical Applications in Acne Pathology

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