Topical Corticosteroids in Dermatology: From Chemical Development to Galenic Innovation and Therapeutic Trends

Gual, Adrià; Pau-Charles, Ignasi; Abeck, Dietrich

doi:10.4172/2155-9554.1000269

Cited by 5 publications

(3 citation statements)

References 30 publications

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“…Commonly used repigmentation therapies for vitiligo that are supported by data from randomized controlled trials include topical agents such as corticosteroids and calcineurin inhibitors (Boniface et al, 2018). In the last decades, corticosteroid derivatives have been designed to simultaneously improve efficacy without reaching the systemic circulation to avoid systemic adverse effects (Gual, Pau‐Charles, & Abeck, 2015). Esterification, increase lipophilicity, and improvement of the characteristics of the vehicle, together with the proper indication and use, have been reported to enhance potency, while improving the safety profile of the molecule (Chi et al, 2017; Gual et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…In the last decades, corticosteroid derivatives have been designed to simultaneously improve efficacy without reaching the systemic circulation to avoid systemic adverse effects (Gual, Pau‐Charles, & Abeck, 2015). Esterification, increase lipophilicity, and improvement of the characteristics of the vehicle, together with the proper indication and use, have been reported to enhance potency, while improving the safety profile of the molecule (Chi et al, 2017; Gual et al, 2015). Another treatment frequently used are calcineurin inhibitors (Cavalié et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

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Macrophage inhibitory factor (MIF) gene polymorphisms are associated with disease susceptibility and with circulating MIF levels in active non‐segmental vitiligo in patients from western Mexico

García-Orozco

Martinez-Magaña

Riera‐Leal

et al. 2020

Molec Gen & Gen Med

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Macrophage inhibitory factor (MIF) gene polymorphisms are associated with disease susceptibility and with circulating MIF levels in active non‐segmental vitiligo in patients from western Mexico

García-Orozco

Martinez-Magaña

Riera‐Leal

et al. 2020

Molec Gen & Gen Med

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“…-Unani physicians often suggest dietotherapy as the first line of treatment or as adjuvant therapy with other modalities of treatment. 35 Psoriatic patients are advised to avoid intake of food that increases the production of Saudāwi Māddah (black bile). Ali Ibn al-Majusi advised the patients to avoid meat and sweet items.…”

Section: Ilāj Bi'l-ghiza (Diet Therapy)mentioning

confidence: 99%

Concept of Bars-e-Aswad (Plaque Psoriasis) and Its Management in Unani System of Medicine

Manzoor

2024

Int J Res Rev

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Plaque Psoriasis is a natural, genetically determined inflammatory skin disorder that affects 1- 3% of the world's population, the prevalence of psoriasis in adults varies from 0.44 to 2.8%, in India. People of any age may be affected, and men and women are equally affected. The word psoriasis is derived from Greek word ‘psora’ meaning ‘itch’ ‘iasis’ meaning ‘action, condition’. Conventional medical practices have been under use for the past half-century for treating psoriasis, but the incessant nature, reoccurrence of the disease, and lack of safe and effective drugs are on the quest. In Unani medicine, plaque psoriasis is known as Bars-e Aswad and treated according to its established etiology. Unani scholars has emphasized the Usool-e-Ilaj (principle of treatment) such as evacuations of black bile (Istifragh or Tanqiyahe Sauda), use of blood purifier (Tasfeeh-e-Dam), Munzijate Sauda (Melancholic concoctives), Mushilate Sauda (Melancholic purgatives), Tabreed Badan (genesis of ratoobat or fluids in the body), try to restore normal temperament (Tadeele Mizaj), topical application of jali (detergent), murakhi (emollient), murattib and mohallil (anti-inflammatory) advia. Methodology: Through ancient unani literature and modern journals related to the concept and management of Bars-e-Aswad (plaque psoriasis). Conclusion: Present review has been studied about concept of Bars-e Aswad (Plaque psoriasis) and its management in unani system of medicine Keywords: Bars-e Aswad, Plaque psoriasis, Unani medicine.

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Keloids Treatment Using Triple Medicine Combination

Teplyi

Grebchenko

2018

Med. Sci. of Ukr.

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Relevance. A lot of conservative approaches have been proposed to the management of keloids, but none of them provides a guaranteed positive result and a stable absence of relapse. Objective: to evaluate the effectiveness and side effects of triple keloid scar therapy. Materials and methods. Thirty-three patients aged 18-69 years, who received treatment of keloids by triple medicine combination therapy, were investigated retrospectively. All patients were divided into two groups. In first one (16 patients) intralesional injections of mixture of 5-fluorouracil, triamcinolone acetonide and bovine origin hyaluronidase were performed. In the second group (17 patients) instead of triamcinolone betamethasone suspension was used. Four sessions of therapy were performed with a monthly interval. Results were assessed 1 month and 6 months after the last session. The planimetric investigation and measurement of scars’ volume were performed. The influence of treatment on the number of telangiectasias within the scar was performed with the help of our method of computer processing of its digital photographs. Results. There was not statistically significant difference in linear size, area and volume of the scars in patients of two groups before beginning of the treatment. One month after the fourth session scars’ width increased statistically significantly. Their length and area also increased but difference did not reach statistically significant level. At the same time maximal height of the scars over surrounding tissues (p<0.001) and their volume (p=0.012 та 0.001) reduced significantly in both groups. There was not difference in percentage of scar volume reduction ((67.4±18.01) % and (74.3±14.71) % correspondingly, p=0.308) in different groups. The main negative effect of treatment was redness of the scars due to purpura and increase of telangiectasias number. Reliable increase of the part of the scars’ surface taken by the telangiectasias was registered in both groups without difference between them. Despite the overall improvement in self-esteem, the patients noted that the change in the color of the scar after the treatment came into the first plane among the factors causing aesthetic dissatisfaction. Supplementary methods of telangiectasias and hyperemia correction were used in 12 patients of the first and 11 patients of the second group. Pain syndrome and itching were eliminated in 11 out of 14 (78.6%) patients in the first group and in 11 out of 15 (73.3%) patients in the second group (p = 0.753). Performed treatment positively influenced patients’ quality of life. Their self-esteem increased essentially ((3.4±2.16) points, p=0.005 and (3.2±1.92) points, p=0.001 correspondingly). At re-examination 6 months after the termination of triple therapy, no statistically significant changes in the size of scars were found, pain and itching did not restore. The quality of life self-esteem remained unchanged. Conclusion. The combined use of 5-fluorouracil, glucocorticoid, and hyaluronidase reduced the protrusion and volume of not-burn keloids in patients of both groups (by (67.4 ± 18.01) % and (74.3 ± 14.71) % respectively (p = 0.308)). Triple medicine therapy permitted to eliminate the pain syndrome and itching in 78.6 % of patients of group where triamcinolone acetonide was used, and in 73.3% of patients who received mixture that included betamethasone suspension (p=0.753). Triple medicine therapy effectiveness, both in term scars’ resizing, and eliminating clinical symptoms and improving the quality of life, was the same for both variants of the combination of drugs. The main side effect, that somewhat worsened the aesthetic result of treatment, was the increase of telangiectasias number. The part of the scar area taken by telangiectasias increased from the (3.4±1.16) % to the (9.7±3.51) %, p<0.001 in the first group and from the (3.3±1.31) % to the (9.7±3.05) %, p<0.001 in the second one. The use of glucocorticoid in triple therapy, which to a lesser extent will stimulate the formation of telangiectasias, will improve the cosmetic result of the treatment.

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Topical Corticosteroids in Dermatology: From Chemical Development to Galenic Innovation and Therapeutic Trends

Cited by 5 publications

References 30 publications

Macrophage inhibitory factor (MIF) gene polymorphisms are associated with disease susceptibility and with circulating MIF levels in active non‐segmental vitiligo in patients from western Mexico

Macrophage inhibitory factor (MIF) gene polymorphisms are associated with disease susceptibility and with circulating MIF levels in active non‐segmental vitiligo in patients from western Mexico

Concept of Bars-e-Aswad (Plaque Psoriasis) and Its Management in Unani System of Medicine

Keloids Treatment Using Triple Medicine Combination

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