Topical Heparin: A Promising Agent for the Prevention of Tracheal Stenosis in Airway Surgery

Sen, Sayan; Meteoğlu, İbrahim; Oğurlu, Mustafa; Şen, Selda; Derinceoz, Onur Ozgun; Barutça, Sabri

doi:10.1016/j.jss.2009.01.028

Cited by 12 publications

(14 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Damaged tissue can be repaired by ECM remodeling and scar formation. Some modulators in the ECM induce a scarless wound: heparin, anti‐transforming growth factor beta, mitomycin C, 5‐fluorouracil, and triamcinolone have been evaluated for prevention of fibrosis . Doxycycline has antimicrobial properties and is also effective in ECM modulation, regulation of wound healing, and immunomodulation .…”

Section: Discussionmentioning

confidence: 99%

Prevention of tracheal inflammation and fibrosis using nitinol stent coated with doxycycline

Choi

Kim

et al. 2017

The Laryngoscope

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Prevention of tracheal inflammation and fibrosis using nitinol stent coated with doxycycline

Choi

Kim

et al. 2017

The Laryngoscope

View full text Add to dashboard Cite

show abstract

“…Therefore, it is possible that soluble heparin at the site of injury could act competitively to release this growth factor from HS binding sites and promote participation in tissue repair. Furthermore, heparin has been found to promote tissue repair in rabbit trachea after topical application in experimental airway surgery (Sen et al, 2009), further suggesting that the ability of heparin to bind a range of growth factors may be useful in the specific situation of tissue repair after localized tissue injury (Table 1). …”

Section: Would Healing and Tissue Repairmentioning

confidence: 99%

Pharmacology of Heparin and Related Drugs

Mulloy

Hogwood

Gray

et al. 2016

Pharmacological Reviews

280

255

View full text Add to dashboard Cite

“…Alternative treatment options studied in animal and human models include steroid injections, topical mitomycin C (MMC), topical heparin, 5-fluorouracil, and halofuginone [2,8,11,13,14,15]. …”

Section: Introductionmentioning

confidence: 99%

The Efficacy of Mitomycin C in the Treatment of Laryngotracheal Stenosis: Results and Experiences with a Difficult Disease Entity

Reichert

Zhao

Galati

et al. 2015

ORL

View full text Add to dashboard Cite

Background/Aims: Laryngotracheal stenosis (LTS) is a difficult entity to treat, with many patients requiring multiple procedures. Our study assessed the efficacy of mitomycin C (MMC) application as complimentary treatment of LTS. Methods: We reviewed clinical charts of patients with operative procedures for LTS between January 2005 and May 2013. Patients were grouped according to mitomycin use. Several outcome measures were assessed, including the number of procedures and time between procedures. Results: Seventy-one patients were included in the study (30 MMC, 41 non-MMC). They underwent similar numbers of procedures (2.3 MMC, 2.0 non-MMC, p > 0.05). The average time between procedures was 360 (MMC) and 178 (non-MMC) days (p = 0.015). Multiple treatments with mitomycin increased the duration between procedures (366 vs. 340 days, multiple vs. single application, p > 0.05). Fewer mitomycin patients underwent procedures for respiratory distress than non-MMC patients (6.6 vs. 19.5%, p > 0.05). Mitomycin use increased the duration between procedures in patients treated specifically for subglottic stenosis (375 vs. 186 days, p > 0.05). Conclusion: Our results and experiences with mitomycin demonstrate it is an effective agent for adjuvant treatment of LTS. Its use lengthens the symptom-free period, with further improvement demonstrated when patients expected to undergo multiple surgeries receive multiple mitomycin treatments.

show abstract

Topical Heparin: A Promising Agent for the Prevention of Tracheal Stenosis in Airway Surgery

Cited by 12 publications

References 36 publications

Prevention of tracheal inflammation and fibrosis using nitinol stent coated with doxycycline

Prevention of tracheal inflammation and fibrosis using nitinol stent coated with doxycycline

Pharmacology of Heparin and Related Drugs

The Efficacy of Mitomycin C in the Treatment of Laryngotracheal Stenosis: Results and Experiences with a Difficult Disease Entity

Contact Info

Product

Resources

About