Topical nanoemulsion therapy reduces bacterial wound infection and inflammation after burn injury

Hemmila, Mark R.; Mattar, Aladdein; Taddonio, Michael; Arbabi, Saman; Hamouda, Tarek; Ward, Peter A.; Wang, Stewart C.; Baker, James R.

doi:10.1016/j.surg.2010.01.001

Cited by 79 publications

(53 citation statements)

References 21 publications

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“…Therefore, starting the appropriate treatment before the agent leads to a systemic infection becomes important in burn patients where A.baumannii colonisation is detected. It has been shown in various studies that the adoption of infection control and prevention standards like proper hand hygiene, isolation rooms, environmental cleanliness and disinfection methods in burn units reduces infections caused by MDR microorganisms [17,18]. Also in our case, these infection control and prevention standards were applied and the transmission of the infection to other patients was limited.…”

Section: Discussionmentioning

confidence: 67%

An Evaluation of Burn Infections Caused by Multidrug Resistant A.baumannii and the Treatment Approach

Selcuk

2011

J Curr Surg

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Background: If not treated properly, A.baumannii infections in burn patients may cause delays in wound healing, graft losses, or even development of sepsis that may lead to death in cases where the bacteria enters the systemic circulation. In this study, our aim is to present the treatment options and their results in patients where burn infections due to multidrug resistant (MDR) A.baumannii have been diagnosed.

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Section: Discussionmentioning

confidence: 67%

An Evaluation of Burn Infections Caused by Multidrug Resistant A.baumannii and the Treatment Approach

Selcuk

2011

J Curr Surg

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“…The rats then received a topical application of 1 × 10 6 colony-forming units of both S. aureus and E. coli in 100 µL and were left for 24 hours for infection to develop. 25 All rats were divided into three groups, ie, three rats in group A, six rats in group B, and three rats in group C. The electrospun NDEM (PLGA/ collagen matrix) was applied to the infected wounds of each rat in group A, while the DEM (PLGA/collagen/antibiotic) was applied to the infected wounds of each rat in group B. The rats in group C were treated with conventional gauze sponge as the control.…”

Section: Healing Of Wound Infection Testmentioning

confidence: 99%

Novel biodegradable sandwich-structured nanofibrous drug-eluting membranes for repair of infected wounds: an in vitro and in vivo study

Chen¹,

Liao²,

Liu³

et al. 2012

IJN

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Background:The purpose of this study was to develop novel sandwich-structured nanofibrous membranes to provide sustained-release delivery of vancomycin, gentamicin, and lidocaine for repair of infected wounds. Methods: To prepare the biodegradable membranes, poly(D, L)-lactide-co-glycolide (PLGA), collagen, and various pharmaceuticals, including vancomycin, gentamicin, and lidocaine, were first dissolved in 1,1,1,3,3,3-hexafluoro-2-propanol. They were electrospun into sandwichstructured membranes with PLGA/collagen as the surface layers and PLGA/drugs as the core. An elution method and a high-pressure liquid chromatography assay were used to characterize in vivo and in vitro drug release from the membranes. In addition, repair of infected wounds in rats was studied. Histological examination of epithelialization and granulation at the wound site was also performed. Results: The biodegradable nanofibrous membranes released large amounts of vancomycin and gentamicin (well above the minimum inhibition concentration) and lidocaine in vivo for more than 3 weeks. A bacterial inhibition test was carried out to determine the relative activity of the antibiotics released. The bioactivity ranged from 40% to 100%. The nanofibrous membranes were functionally active in treating infected wounds, and were very effective as accelerators in early-stage wound healing. Conclusion: Using the electrospinning technique, we will be able to manufacture biodegradable, biomimetic, nanofibrous, extracellular membranes for long-term delivery of various drugs.

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“…In the world there are already many topical therapies available for the burn injuries, such as, 1% silver sulfadiazine (SSD), moist exposed burn ointment (MEBO), mafenide acetate 10% cream, and povidone iodine (Hemmila et al, 2010, Jewo et al, 2009, Vloemans et al, 2003. But there were gradually some problems found in the treatments, for example, disturbing evidence has appeared that SSD could stimulate the inflammatory and cause the injury to the wounds against the healings (Li, 2011).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Effectiveness in a Novel Wound Healing Ointment-Crocodile Oil Burn Ointment

Li¹,

Deng²,

Zhang³

et al. 2016

Afr J Tradit Complement Altern Med

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Background: Crocodile oil and its products are used as ointments for burns and scalds in traditional medicines. A new ointment formulation -crocodile oil burn ointment (COBO) was developed to provide more efficient wound healing activity. The purpose of the study was to evaluate the burn healing efficacy of this new formulation by employing deep second-degree burns in a Wistar rat model. The analgesic and anti-inflammatory activities of COBO were also studied to provide some evidences for its further use. Materials and methods:The wound healing potential of this formulation was evaluated by employing a deep second-degree burn rat model and the efficiency was comparatively assessed against a reference ointment -(1% wt ⁄ wt) silver sulfadiazine (SSD). After 28 days, the animals were euthanized and the wounds were removed for transversal and longitudinal histological studies. Acetic acid-induced writhing in mice was used to evaluate the analgesic activity and its anti-inflammatory activity was observed in xylene -induced edema in mice. Results: COBO enhanced the burn wound healing (20.5±1.3 d) as indicated by significant decrease in wound closure time compared with the burn control (25.0±2.16 d) (P<0.01). Hair follicles played an importance role in the physiological functions of the skin, and their growth in the wound could be revealed for the skin regeneration situation. Histological results showed that the hair follicles were well-distributed in the post-burn skin of COBO treatment group, and the amounts of total, active, primary and secondary hair follicles in post-burn 28-day skin of COBO treatment groups were more than those in burn control and SSD groups. On the other hand, the analgesic and anti-inflammatory activity of COBO were much better than those of control group, while they were very close to those of moist exposed burn ointment (MEBO). Conclusions: COBO accelerated wound closure, reduced inflammation, and had analgesic effects compared with SSD in deep second degree rat burn model. These findings suggest that COBO would be a potential therapy for treating human burns.

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Topical nanoemulsion therapy reduces bacterial wound infection and inflammation after burn injury

Cited by 79 publications

References 21 publications

An Evaluation of Burn Infections Caused by Multidrug Resistant A.baumannii and the Treatment Approach

An Evaluation of Burn Infections Caused by Multidrug Resistant A.baumannii and the Treatment Approach

Novel biodegradable sandwich-structured nanofibrous drug-eluting membranes for repair of infected wounds: an in vitro and in vivo study

Evaluation of Effectiveness in a Novel Wound Healing Ointment-Crocodile Oil Burn Ointment

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