Topographical and Histological Localization of Dysplasias, Carcinomata in Situ, Microinvasions, and Microcarcinomata

Cytokeratin expression in squamous metaplasia of the human uterine cervix

“…The former is characteristically composed of nonkeratinizing stratified squamous epithelium, while the latter * To whom offprint requests should be sent and Hadassah Hospital, Jerusalem, Israel ** Affiliated with the Medical School of The Hebrew University contains a simple epithelial monolayer of columnar cells which line the mucosal surface and invaginate into the stroma. The sharp squamocolumnar junction detected between the two areas is normally located at the cervical portio [S, 121. This boundary area has been found to be the most common site for the development of squamous metaplasia [6,12,431. This metaplasia is preceded by the outward extension of the endocervical mucosa into the exocervical portion, a process denoting erosion or ectopy [12].…”