Torsades de pointes et hypomagnésémie

Marsepoil, T.; Blin, F.; Hardy, F.; Letessier, G.; Sebbah, J.-L.

doi:10.1016/s0750-7658(85)80253-7

Cited by 7 publications

(2 citation statements)

References 5 publications

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“…Hypokalemia has been reported to be present in 17% to 70% of patients who have developed drug-induced torsades de pointes. 24–27 Similarly, hypomagnesemia has been reported to be a contributing factor to numerous published cases of drug-induced torsades de pointes. 27–29 Therefore, maintenance of serum potassium and magnesium concentrations within the normal range is important before administration of ibutilide, and magnesium supplementation may mitigate the risk of torsades de pointes.…”

Section: Rhythm Controlmentioning

confidence: 99%

2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

Joglar,

Chung,

Armbruster

et al. 2024

Circulation

578

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AIM The “2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation” provides recommendations to guide clinicians in the treatment of patients with atrial fibrillation. METHODS A comprehensive literature search was conducted from May 12, 2022, to November 3, 2022, encompassing studies, reviews, and other evidence conducted on human subjects that were published in English from PubMed, EMBASE, the Cochrane Library, the Agency for Healthcare Research and Quality, and other selected databases relevant to this guideline. Additional relevant studies, published through November 2022, during the guideline writing process, were also considered by the writing committee and added to the evidence tables, where appropriate. STRUCTURE Atrial fibrillation is the most sustained common arrhythmia, and its incidence and prevalence are increasing in the United States and globally. Recommendations from the “2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation” and the “2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation” have been updated with new evidence to guide clinicians. In addition, new recommendations addressing atrial fibrillation and thromboembolic risk assessment, anticoagulation, left atrial appendage occlusion, atrial fibrillation catheter or surgical ablation, and risk factor modification and atrial fibrillation prevention have been developed.

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Section: Rhythm Controlmentioning

confidence: 99%

2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

Joglar,

Chung,

Armbruster

et al. 2024

Circulation

578

View full text Add to dashboard Cite

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“…Hence, in the conclusion, mechanism of the action of Mg is similar to the Ca channel blockers. [3] Hypomagnesemia has been associated with hypocalcemia. However, decreased body Mg can cause a depletion in PTH levels, raise in tissue resistance to PTH, and reduce active Vitamin D concentration [4] and ultimately lead to decreased serum Ca.…”

mentioning

confidence: 99%

Correlation of magnesium and calcium in the management of cardiac arrhythmia: Perspectives for better outcome

Patel

Jagrit

Madole

et al. 2021

AUJMSR

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Objectives: To find correlation between serum Mg, serum Ca, and cardiac arrhythmia. Materials and Methods: The present case–control analytical study includes records of 100 participants; 50 patients (both male and female average age: 47 ± 12 years, mean ± SD) admitted during the period of March 2019–March 2020 into the Coronary Care Unit of LG Hospital, AMCMET Medical College who were clinically diagnosed as arrhythmia and 50 subjects for control group from OPD patients coming to the same institution for health check-up. Mg was estimated with xylitol blue colorimetric end-point method and Ca was estimated by NM-BAPTA Method by Roche Cobas c311 instrument. Results: In 50 cases, mean Mg value was 1.454 mg/dl and SD 0.2566 while in control group, mean value was 2.2 mg/dl and SD is 0.3110 with 95% confidence interval of 1.381–1.527 and 2.199–2.375 for cases and controls group, respectively, which was statistically significant (p < 0.0001). In 50 cases, mean Ca value was 8.6426 mg/dl and SD 1.3 mg/dl while in control group, mean value was 9.5 mg/dl and SD 0.47 with 95% confidence interval of 8.268–9.018 and 9.377–9.643 for cases and controls, respectively, which was statistically significant (p < 0.0028) and shows correlation between serum Ca and serum Mg which are low in cardiac arrhythmias. Receiver operating characteristic analysis of Ca: Mg (3.36) ratio showed optimum cutoff in diagnosis of cardiac arrhythmia. Conclusion: We concluded that serum Mg and Ca along with Ca/Mg ratio should be considered as an important parameter for investigation of cardiac disorders, especially for patients of cardiac arrhythmia.

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Elevated plasma free fatty acid concentrations do not modify cardiac repolarization in patients treated by electrolyte-glucose-insulin infusion

Nappo

Loreto

Giugliano

et al. 2002

J Endocrinol Invest

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Fat emulsion infusion is routinely used as a source of calories and essential fatty acids for critically ill patients who may be at risk for acquired ventricular repolarization alterations due either to drugs or electrolyte disturbances. The aim of this study was to evaluate whether acute elevations of plasma free fatty acid concentrations influence the corrected Q-T interval (Q-Tc), Q-Tc dispersion and sympathetic nervous system activity in patients requiring parenteral nutrition. Thirty hospitalized patients (mean +/- SD: 62 +/- 17 yr of age) requiring total parenteral nutrition received an infusion of 10% (500 ml) triacylglycerol emulsion as a source of calories (450 Kcal); on another occasion, and in random order, the same patients received an infusion of 20% (500 ml) triacylglycerol emulsion (900 Kcal). The infusion lasted 8 h and was preceded by a sc injection of heparin (5,000 U). Infusions of both 10% and 20% triacylglycerol emulsion increased plasma free fatty acid (p<0.00 1) and triacylglycerol (p<0.01) concentrations, and was associated with no significant change in mean BP, heart rate, and plasma catecholamines. At baseline, Q-Tc and Q-Tc dispersion were within the normal range (<440 milliseconds for QTc and <40 ms for QTc-d) and did not show any significant change at any time during infusion of triacylglycerol emulsion at both concentrations. In the setting of a balanced parenteral nutrition, acute elevation of plasma free fatty acid concentrations in critically ill patients do not modify ventricular repolarization.

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Torsades de pointes et hypomagnésémie

Cited by 7 publications

References 5 publications

2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

Correlation of magnesium and calcium in the management of cardiac arrhythmia: Perspectives for better outcome

Elevated plasma free fatty acid concentrations do not modify cardiac repolarization in patients treated by electrolyte-glucose-insulin infusion

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