TORULOPSIS GLABRATA SEPTICqMIA TREATED WITH 5-FLUOROCYTOSINE

Webb, A. J.; Speller, D. C. E.; Buckler, K. G.

doi:10.1016/s0140-6736(70)92438-4

Cited by 81 publications

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“…5-Fluorocytosine has been used with success in urinary infection by Candida albicans (Davies and Reeves, 1971;Schonebeck, Steen, and Tarnvik, 1972;Holt and Newman, 1973) though treatment sometimes fails. One case of successful treatment of T. glabrata septicaemia has been recorded (Webb, Speller, and Buckler, 1970). The two patients described here were rapidly cured.…”

Section: Commentmentioning

confidence: 66%

Torulopsis glabrataurinary tract infection treated with 5-fluorocytosine

Speller

1974

J Clin Pathol

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Section: Commentmentioning

confidence: 66%

Torulopsis glabrataurinary tract infection treated with 5-fluorocytosine

Speller

1974

J Clin Pathol

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“…Use of 5-FC for the treatment of fungal infections in man first appeared in the literature in 1967 (5), since which time 10 articles in the English literature have reported experience with a total of 22 patients with cryptococcal disease, 19 with Candida infection, and 1 with Torulopsis glabrata septicemia (3,4,(8)(9)(10)(15)(16)(17)(18)(19). Although this agent is undergoing clinical investigation in a number of centers at the present time, relatively little is known about its pharmacological properties.…”

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confidence: 99%

Pharmacological Studies with 5-Fluorocytosine

Block

Bennett

1972

Antimicrob Agents Chemother

108

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A cylinder plate bioassay for 5-fluorocytosine (5-FC) is described which permits determination of 5-FC concentrations in biological fluids in the presence of amphotericin B. Using this assay, we determined serum concentrations in 12 patients after a single dose of drug and in 8 patients receiving daily 5-FC at 6-hr intervals (4 to 120 days). Drug was detectable in serum as early as 0.5 hr and concentrations were measurable as long as 24 hr after a dose, regardless of renal function. Peak concentrations occurred 6 hr after the initial drug dose, but were seen between 1 and 2 hr after a dose in all patients receiving a minimum of 4 days of therapy. Mild to moderate renal impairment produced marked increases in peak 5-FC concentrations in the serum of a group of eight patients on three different dosage schedules. Five patients were studied before and after amphotericin B-induced renal insufficiency. Peak concentrations increased from 14 to 142% concomitant with the change in renal function. Parallel studies in rabbits confirmed the results in our patients. 5-FC half-life in the serum of 10 rabbits increased from 3.35 0.27 to 24.63 0.70 hr after experimentally induced acute renal failure. Concentrations of 5-FC in the cerebrospinal fluid of five patients ranged from 17 to 62 ,ug/ml and were 74.4 + 5.6% of simultaneously determined serum concentrations. The effect of renal function on 5-FC concentrations in cerebrospinal fluid was similar to that seen with serum.

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“…5th Congr. ISHAM, Paris) and that it is also effective against infections due to Torulopsis glabrata (17). It is relatively nontoxic (13,14), but clinical experience has shown that the development of resistance is common (15).…”

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In Vitro Studies of 5-Fluorocytosine Resistance in Candida albicans and Torulopsis glabrata

Normark

Schönebeck

1972

Antimicrob Agents Chemother

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Spontaneous mutants of Candida albicans resistant to 5-fluorocytosine (5-FC) were isolated from a strain susceptible to 5-FC. These mutants were compared with 5-FC-resistant strains of C. albicans and Torulopsis glabrata isolated from patients treated with the drug and from untreated patients. Resistance to 5-FC was in all cases followed by a decreased susceptibility to 5-fluorouracil. Most strains were also more resistant to 5-fluorouridine and had a lowered incorporation of uridine. In one spontaneous mutant totally resistant to all three 5-fluoropyrimidines, the uridine monophosphate pyrophosphorylase activity was greatly decreased. The 5-FC-resistant strains were of two main phenotypic classes. Class one was unaffected by 5-FC at the highest concentration tested. The growth rate of strains belonging to the other class was markedly decreased by low concentrations of 5-FC, but these strains were still able to form colonies after 7 days of incubation on plates containing very high concentrations of the drug (2,000 ,g/ml). The frequency of spontaneous mutation of a susceptible strain to 5-FC resistance was fairly high. The number of mutants growing on media containing 5-FC was unchanged by concentrations ranging from 25 to 500 ,g/ml.

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TORULOPSIS GLABRATA SEPTICqMIA TREATED WITH 5-FLUOROCYTOSINE

Cited by 81 publications

References 0 publications

Torulopsis glabrataurinary tract infection treated with 5-fluorocytosine

Torulopsis glabrataurinary tract infection treated with 5-fluorocytosine

Pharmacological Studies with 5-Fluorocytosine

In Vitro Studies of 5-Fluorocytosine Resistance in Candida albicans and Torulopsis glabrata

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