Total-body skeletal muscle mass: development and cross-validation of anthropometric prediction models

Lee, Robert C.; Wang, ZiMian; Heo, Moonseong; Ross, Robert; Janssen, Ian; Heymsfield, Steven B.

doi:10.1093/ajcn/72.3.796

Cited by 671 publications

(703 citation statements)

References 16 publications

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“…Participants were instructed on proper breathing and lifting form for each movement (Serra Rexach et al 2009). We estimated whole-body muscle mass as detailed elsewhere (Lee et al 2000).…”

Section: Methodsmentioning

confidence: 99%

The K153R variant in the myostatin gene and sarcopenia at the end of the human lifespan

González-Freire

Rodríguez-Romo

Santiago

et al. 2010

AGE

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We studied the A55T, E164K, I225T, K153R and P198A variants in the myostatin (GDF8) gene, muscle strength and mass, and physical function during daily living in 41 nonagenarians [33 women, age range, 90, 97]. No participant carried a mutant allele of the aforementioned variants, except three participants (all women), who carried the R allele of the K153R polymorphism, with one of them (woman aged 96 years) being homozygous. Overall, in KR women muscle phenotype values (1RM leg press and estimated muscle mass) were low-to-normal compared to the whole group (∼25th-50th percentile), and their functional capacity (Barthel and Tinetti tests) was normal. In the woman bearing the RR genotype, values of muscle mass and functional capacity were below the 25th percentile. She is the first RR Caucasian whose phenotype has been characterised specifically. In summary, heterozygosity for the GDF8 K153R polymorphism does not seem to exert a negative influence on the muscle phenotypes of women who are at the end of the human lifespan, yet homozygosity might do so. More research on larger cohorts of nonagenarians is needed to corroborate the present findings.

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“…Participants were instructed on proper breathing and lifting form for each movement (Serra Rexach et al 2009). We estimated whole-body muscle mass as detailed elsewhere (Lee et al 2000).…”

Section: Methodsmentioning

confidence: 99%

The K153R variant in the myostatin gene and sarcopenia at the end of the human lifespan

González-Freire

Rodríguez-Romo

Santiago

et al. 2010

AGE

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“…This widely known author worked mainly on Brazilian people, who are an important populational reference for South American neighbors like Uruguayans. Albeit a published validation was not available, it belongs to a recognized group of other methods which have been developed with the aim of calculating body composition (Jackson and Pollack, 1985;Heymsfield et al, 1997;Lee et al, 2000). The same methodology was followed in our first study on body composition (Ronco et al, 2009).…”

Section: Body Composition and Somatotypementioning

confidence: 99%

Risk Factors for Premenopausal Breast Cancer: A Case-control Study in Uruguay

Ronco¹,

Stéfani²,

Deneo‐Pellegrini³

2012

Asian Pacific Journal of Cancer Prevention

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In order to thoroughly analyze risk factors of breast cancer (BC) in premenopausal Uruguayan women, a case-control study was carried out at the Pereira Rossell Women's Hospital, Montevideo, where 253 incident BC cases and 497 frequency-matched healthy controls were interviewed on menstrual and reproductive story, were administered a short food frequency questionnaire and undertook a series of body measurements necessary to calculate body composition and somatotype. Odds ratio (OR) coefficients were taken as estimates of relative risk derived from unconditional logistic regression. Among the classical risk factors, only the family history of BC in first degree relatives was significantly associated with risk of premenopausal BC (OR=2.20, 95% CI 1.33-3.62). Interestingly, this risk factor was found to be stronger in women of ages >40 (OR=4.05, 95% CI 2.10-7.81), late menarche (OR= 2.39, 95% CI 1.18-4.

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“…One study [82] assessed body composition using Dual Energy X-ray Absorptiometry (DXA) to derive ASM, calculated as the sum of lean soft tissue mass in both arms and legs [90] and further adjusted by BMI to establish the ASM index calculated using the formula, ASM/BMI [91,92]. Tyrovolas et al [85] however assessed ASM using a predictive equation proposed by Lee et al [93] to determine the ASM index. Isometric hand-grip strength, gait speed or both were assessed in the remaining three studies [78,83,86].…”

Section: Adherence To the Mediterranean Diet Physical Frailty And Samentioning

confidence: 99%

Mediterranean Diet attenuates risk of frailty and sarcopenia: New insights and future directions

McClure

Villani

2017

JCSM Clinical Reports

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Sarcopenia and physical frailty are associated with progressive disability and predictive of negative health outcomes. Dietary interventions are considered the cornerstone in the management of sarcopenic symptomology and physical frailty. However few studies have investigated preventative strategies. Moreover, most studies have focused on the efficacy of individual nutrients or supplements rather than dietary patterns. The Mediterranean Diet (MedDiet) is a dietary pattern that provides evidence for an association between diet quality, healthy ageing and disease prevention. The purpose of this paper was to examine, synthesise and develop a narrative review of the current literature, investigating the potential benefits associated with adherence to a MedDiet and attenuation of physical frailty and sarcopenic symptomology in older adults. We also explored the underlying mechanisms underpinning the potential benefits of the MedDiet on ameliorating physical frailty and sarcopenic symptomology. Synthesis of the reviewed literature is suggestive of a decreased risk of physical frailty and sarcopenic symptomology with greater adherence to a MedDiet. We identified the anti-inflammatory and high antioxidant components of the MedDiet as two potential biological mechanisms involved. Due to a lack of evidence from RCTs to support the proposed physiological mechanisms, we suggest investigating these observations in older adults with type 2 diabetes (T2DM) whom are vulnerable to physical frailty and disability. A number of biological mechanisms describing the pathway to disability in older adults with T2DM have been postulated with many of these mechanisms potentially mitigated with dietary interventions involving the MedDiet. Exploring these mechanisms with the use of well-designed, longer-term dietary intervention studies in older adults with an increased vulnerability to physical frailty and sarcopenia is warranted.

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Total-body skeletal muscle mass: development and cross-validation of anthropometric prediction models

Abstract: These 2 anthropometric prediction models, the first developed in vivo by using state-of-the-art body-composition methods, are likely to prove useful in clinical evaluations and field studies of SM mass in nonobese adults.

Cited by 671 publications

References 16 publications

The K153R variant in the myostatin gene and sarcopenia at the end of the human lifespan

The K153R variant in the myostatin gene and sarcopenia at the end of the human lifespan

Risk Factors for Premenopausal Breast Cancer: A Case-control Study in Uruguay

Mediterranean Diet attenuates risk of frailty and sarcopenia: New insights and future directions

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