Total elbow arthroplasty in patient with severe von Willebrand disease

Kotela, Ireneusz; Żbikowski, Piotr; Ambroziak, Paweł; Buczma, Anna; Gwozdowska, Adela; Kotela, Andrzej; Windyga, Jerzy

doi:10.1111/hae.12555

Cited by 6 publications

(4 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The clinical course of IBD is dominated by spontaneous bleeding episodes, leading to irreversible destruction of affected joints. Severe arthropathy remains the major cause of morbidity for hemophilia, and the knee is the most commonly involved joint [1–6]. …”

Section: Introductionmentioning

confidence: 99%

Revision Knee Arthroplasty in Patients with Inherited Bleeding Disorders: A Single-Center Experience

et al. 2017

View full text Add to dashboard Cite

BackgroundThe results of total knee arthroplasty (TKA) in patients with inherited bleeding disorders (IBDs) are poorer when compared with those in the general population, with a notably higher risk of complications and higher revision rates. Thus, revision procedures are becoming a growing concern in this group of patients. The aim of this study was to evaluate the results of revision TKA in patients with IBD.Material/MethodsA retrospective cohort study with longitudinal assessment of hemophilia patients scheduled for revision TKA between January 2010 and September 2015 was performed. The clinical status of the patients was assessed based on the Knee Society Score, and the Numeric Rating Scale was used to assess knee pain severity and patient satisfaction with the surgery. Radiological examination, post-operative complications, and reinterventions were recorded and analyzed.ResultsVery good results were obtained in all patients treated for aseptic loosening of the implant. However, inferior results were found in cases with infection. All patients operated on for aseptic loosening required only single-stage TKA, whereas patients with infection underwent multiple interventions. Complications were observed only in cases with infection.ConclusionsOur study clearly outlined the differences in results based on failure mode, with far inferior results obtained in cases with infection. Given the lack of data in this area as well as the high specificity of this population, further high-quality studies are needed.

show abstract

Section: Introductionmentioning

confidence: 99%

Revision Knee Arthroplasty in Patients with Inherited Bleeding Disorders: A Single-Center Experience

et al. 2017

View full text Add to dashboard Cite

show abstract

“…When the medical treatment fails to control synovitis, radioactive or surgical synovectomy may be alternatives to control bleeding . In case of advanced arthropathy, radius head resection or elbow prosthesis may be required .…”

Section: Discussionmentioning

confidence: 99%

Benefits of radial head excision in patients with haemophilia: mid‐term functional results

et al. 2015

View full text Add to dashboard Cite

show abstract

“…It is closely related to decreasing the quality of life and numerous complications resulting from BMD reduction, including fractures and accelerated progress of osteoarthritis [41, 42]. Osteoporotic lesions also occur in numerous articular pathologies, such as rheumatoid arthritis or hemophilic arthropathy [43–45]. It results in very serious secondary consequences comprising the limitation or complete immobilization of patients, cardiovascular, infectious, or thrombotic complications [46].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Role of CX3CL1/CX3CR1 Signaling Axis Activity in Osteoporosis

Turczyn

Dobies-Krzesniak

Frasuńska

et al. 2019

Mediators of Inflammation

View full text Add to dashboard Cite

Osteoporosis is a civilization disease which is still challenging for contemporary medicine in terms of treatment and prophylaxis. It results from excessive activation of the osteoclastic cell line and immune cells like macrophages and lymphocytes. Cell-to-cell inflammatory information transfer occurs via factors including cytokines which form a complex network of cell humoral correlation, called cytokine network. Recently conducted studies revealed the participation of CX3CL1 chemokine in the pathogenesis of osteoporosis. CX3CL1 and its receptor CX3CR1 present unique properties among over 50 described chemokines. Apart from its chemotactic activity, CX3CL1 is the only chemokine which may function as an adhesion molecule which facilitates easier penetration of immune system cells through the vascular endothelium to the area of inflammation. The present study, based on world literature review, sums and describes convincing evidences of a significant role of the CX3CL1/CX3CR1 axis in processes leading to bone mineral density (BMD) reduction. The CX3CL1/CX3CR1 axis plays a principal role in osteoclast maturation and binding them with immune cells to the surface of the bone tissue. It promotes the development of inflammation and production of many inflammatory cytokines near the bone surface (i.e., TNF-α, IL-1β, and IL-6). High concentrations of CX3CL1 in serum are directly proportional to increased concentrations of bone turnover and inflammatory factors in human blood serum (TRACP-5b, NTx, IL-1β, and IL-6). Regarding the fact that acting against the CX3CL1/CX3CR1 axis is a potential target of immune treatment in osteoporosis, the number of available papers tackling the topic is certainly insufficient. Therefore, it seems justified to continue research which would precisely determine its role in the metabolism of the bone tissue as one of the most promising targets in osteoporosis therapy.

show abstract

Total elbow arthroplasty in patient with severe von Willebrand disease

Cited by 6 publications

References 9 publications

Revision Knee Arthroplasty in Patients with Inherited Bleeding Disorders: A Single-Center Experience

Revision Knee Arthroplasty in Patients with Inherited Bleeding Disorders: A Single-Center Experience

Benefits of radial head excision in patients with haemophilia: mid‐term functional results

Role of CX3CL1/CX3CR1 Signaling Axis Activity in Osteoporosis

Contact Info

Product

Resources

About