2008
DOI: 10.1016/j.ymgme.2007.12.001
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Total homocysteine, B-vitamins and genetic polymorphisms in patients with classical phenylketonuria

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Cited by 16 publications
(30 citation statements)
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“…Hcy levels were low or in the lower part of the reference range in most patients. Our findings are in accordance with other studies reporting about twice as high folate levels in PKU children and young adults than in controls (Colome et al 2003;Huemer et al 2008). A recent report of 19 Norwegian latetreated adults found high intakes of folic acid and corresponding high blood folate concentrations (Wiig et al 2013).…”
Section: Discussionsupporting
confidence: 93%
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“…Hcy levels were low or in the lower part of the reference range in most patients. Our findings are in accordance with other studies reporting about twice as high folate levels in PKU children and young adults than in controls (Colome et al 2003;Huemer et al 2008). A recent report of 19 Norwegian latetreated adults found high intakes of folic acid and corresponding high blood folate concentrations (Wiig et al 2013).…”
Section: Discussionsupporting
confidence: 93%
“…While a higher dietary intake of natural folate is linked with reduced cancer risk (Duthie 2011;Figueiredo et al 2009), there are also reports that supplementation with synthetic folic acid actually increases cancer risk (Cole et al 2007;Wien et al 2012;Ebbing et al 2009;Figueiredo et al 2009), cancer mortality, and all-cause mortality (Ebbing et al 2009). Both high and low blood concentrations of folate and vitamin B12 have been reported in PKU patients compared to controls (Colome et al 2003;Huemer et al 2008;Schulpis et al 2002). Colomé et al found lower levels of homocysteine (hcy) concurrent with higher concentrations of folate and vitamin B12 (Colome et al 2003), while Schulpis et al found higher hcy levels and lower folate and vitamin B12 concentrations compared to controls (Huemer et al 2008;Schulpis et al 2002).…”
Section: Introductionmentioning
confidence: 99%
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“…According to some authors, PKU and HPA patients may receive excessive amounts of vitamin B 12 and folate (40)(41)(42). The risks of possible side effects from such a status, and particularly in relation to tumor growth are often discussed in literature.…”
Section: Discussionmentioning
confidence: 99%
“…It may influence growth, as there are differences in growth patterns between various groups/countries (Verkerk et al 1994; Hoeksma et al 2005; Acosta et al 1998; Schaefer et al 1994; Dobbelaere et al 2003). It clearly may result in deficiencies of, for example, long-chain unsaturated fatty acids and vitamin B 12 (Hanley et al 1993; Hvas et al 2006; Huemer et al 2008). It results in decreased bone density (Zeman et al 1999, Modan-Moses et al 2007).…”
Section: Drawbacks Of the Dietary Treatmentmentioning
confidence: 99%