Total IgE at 6 months predicts remittance or persistence of atopic dermatitis at 14 months

Abstract

Some patients with infantile atopic dermatitis (AD) achieve remission around 1 year old, but in others it persists. The difference between them is unclear. We performed a birth cohort study to find the markers predicting the outcome of infantile AD. We followed up a cohort (n = 314) from birth to 14 months of age, and cord blood was taken from the participants. Some of them (n = 144) had a physical examination and a blood test at 6 and 14 months of age. The subjects who had AD at 6 months (n = 34) were divided into two groups, named the transient group (those who had no AD at 14 months of age; n = 16) and the persistent group (those who still had AD at 14 months of age; n = 18). Then, laboratory data were compared between these two groups. Percentage of CD8 in cord blood lymphocytes and total IgE at 6 months of age in the persistent group was significantly higher than those of the transient group. The area under the curves of a receiver operating characteristic analysis were 0.792 (p = 0.007) and 0.722 (p = 0.027). In the persistent group, total IgE, percentages of T-helper (Th) 2 and phytohemagglutinin-induced IL-4 production from peripheral blood mononuclear cells at 14 months of age were also significantly higher than those of the transient group. Thus Th2 polarization in the persistent group was confirmed. In clinical use, total IgE at 6 months of age is the most useful predictive marker to know the outcome of infantile AD. The clinical trial registration ID is UMIN000002926.

Association between egg and staphylococcal superantigen IgE sensitizations in atopic dermatitis

“…8 In addition, Kawamoto et al have more recently shown that egg white IgE sensitization at 6 months in infants with AD is significantly associated with more persistent AD. 10 These observations are consistent with the notion that the subgroup of AD infants with food IgE sensitization may be predisposed to involve a more T helper 2-biassed adaptive immunity in cutaneous inflammation. This is supported by the current observation that IgE sensitization to egg white is strongly associated with IgE sensitization to staphylococcal superantigens in older children with AD.…”

Persistence of atopic dermatitis (AD): A systematic review and meta-analysis

“…6,23,28,31,44,45,48 The duration of AD persistence was significantly higher in females (median: 9.0 years; mean ± SE: 12.7 ± 0.2 years) compared with males (median: 7.0 years; mean±SE: 11.7 ± 0.2 years) (HR 1.15; 95% CI 1.04-1.27; P = .006) (Fig 2, E).…”

“…After review of the titles and abstracts, 9326 were excluded; an additional 634 articles were excluded after full-text review. In total, 46 studies were included in the review, of which 44 had valid frequency data that could be pooled, 7 had valid data to assess the effects of gender, 6,23,28,31,44,45,48 6 for allergen sensitization, 6,17,23,36,40,45 and 3 for baseline AD severity 17,28,40 on disease persistence. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram is presented in Fig 1. …”

Detection of ovomucoid‐specific low‐affinity IgE in infants and its relationship to eczema

“…We conducted the Gifu Allergy and Immunology Cohort Study (GAICS) (UMIN‐CTR registration number: UMIN000002926) , the details of which are described elsewhere . Written informed consent and CB samples were obtained at the time of birth.…”