Total orthotopic heart transplantation for primary cardiac rhabdomyosarcoma: factors influencing long-term survival

Grandmougin, Daniel; Fayad, Georges; Decoene, Christophe; Pol, Annie; Warembourg, H

doi:10.1016/s0003-4975(01)02480-8

Cited by 39 publications

(25 citation statements)

References 11 publications

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“…Due to their rarity, primary MV tumors are usually presented in the literature as case reports [5,6,7,8,9,10,11,12,13,14,15,16,17,18,19]. This retrospective study describes the surgical treatment of 11 patients with primary MV tumors from a single cardiac surgical center during a 25-year period.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, aggressive chemotherapy or radiotherapy is mandatory and surgery alone is not sufficient to cure the patient or to significantly improve life expectancy. In 2001, Grandmougin et al [9] reported a 102-month survival of a patient who underwent a heart transplant for primary rhabdomyosarcoma without any signs of metastasis. Although it is probably uncommon to achieve such a long survival, they argued that transplantation remained the best option for patients with primary cardiac sarcoma if no metastatic locations were found.…”

Section: Discussionmentioning

confidence: 99%

“…Our data indicate that primary MV tumors accounted for 0.011% (11/95,980) of all open-heart operations and 1.62% (11/678) of primary heart tumors. To date, the majority of information regarding primary MV tumors has accumulated from either scattered case reports [5,6,7,8,9,10,11,12,13,14,15,16,17,18,19] or general series of heart tumors [20,21,22,23,24], while there are no larger surgical cohorts on this rare entity. In this paper, we present our experience with primary MV tumors in a series of 11 patients, based on our previous cohort [25], in terms of clinical and pathological features and report the long-term results of surgical treatment over a 25-year period.…”

Section: Introductionmentioning

confidence: 99%

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Surgical Treatment for Primary Mitral Valve Tumor: A 25-Year Single-Center Experience

Ma²,

Sun³

et al. 2011

Cardiology

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Objective: Primary mitral valve (MV) tumor is a rare lesion, and to date, there have been few larger surgical series of MV tumors. We retrospectively analyzed 11 cases of primary MV tumors regarding clinical and pathological features, surgical procedure and long-term outcomes. Methods: From November 1983 to December 2008, we operated on 11 patients (age 36.3 ± 17.7 years, weight 55.4 ± 11.2 kg) with primary MV tumors. Symptoms were cardiac in 8 cases (72.7%) and neurologic in 3 (26.3%). Surgical procedures included en bloc excision and MV repair in 8 cases and tumor resection and MV replacement in 3. No radiotherapy or chemotherapy was given to patients with malignant tumors. Results: Pathological diagnosis was papillary fibroelastoma in 3 cases, myxoma in 3, lymphangioma in 1, lipoma in 1, hemangioma in 1 and sarcoma in 2. No early deaths or complications occurred. Late death occurred in 2 patients with sarcoma 1 year postoperatively. At the latest follow-up, with a maximum of 25 years (mean 10.6 ± 8.8), the 9 survivors were in New York Heart Association functional class I with normal MV function and no echocardiographic evidence of local recurrence. Conclusions:The majority of primary MV tumors are benign. They can cause cardiac or neurologic symptoms and should be excised as soon as a diagnosis is made. For benign tumors, valve-sparing resection and valve repair are often possible with excellent long-term outcomes. The prognosis of malignant MV tumors is poor.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Surgical Treatment for Primary Mitral Valve Tumor: A 25-Year Single-Center Experience

Ma²,

Sun³

et al. 2011

Cardiology

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“…In contrast, local extension, such as pericardial location may not exclude the possibility of transplantation. Although long term survivors are known to be extremely rare, the limited experience reported by some authors in the literature confirms that heart transplantation, including in some cases a local pericardial and pleural resection, may be consistent with long term survival without relapse [49]. Despite the usual admittedly dismal prognosis related to the development of local or distant recurrence, cardiac transplantation can be mainly proposed for selected patients with no vascular cardiac sarcoma and no obvious distant metastases.…”

mentioning

confidence: 98%

“…Orthotopic cardiac transplantation is a controversial treatment for primary cardiac sarcoma, but has been associated with prolonged survival in selected cases [49][50][51]. Cardiac transplantation for unresectable tumours has been described, although its use is limited by possible explosive recurrence postoperatively probably related to immunosuppressive therapy.…”

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confidence: 99%

Surgical treatment of cardiac tumors - an overview and presentation of interesting cases

2011

Cardiovasc Med

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Tumors of the Heart and Great Vessels

Chahinian¹,

Gutstein²,

Fuster³

2017

Holland‐Frei Cancer Medicine

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Overview Primary tumors of the heart and great vessels are rare, but secondary tumors are significantly more common. Clinical manifestations of cardiac tumors depend on the location and size of the mass, not on the histopathology of the tumor. Several noninvasive imaging modalities including echocardiography, cardiac MRI, cardiac CT, and PET are currently available to provide complementary information on the location, extent, and tissue characteristics of a cardiac tumor. The clinical management of patients with cardiac tumors varies based on the type of tumor, clinical symptoms, and overall prognosis.

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Total orthotopic heart transplantation for primary cardiac rhabdomyosarcoma: factors influencing long-term survival

Cited by 39 publications

References 11 publications

Surgical Treatment for Primary Mitral Valve Tumor: A 25-Year Single-Center Experience

Surgical Treatment for Primary Mitral Valve Tumor: A 25-Year Single-Center Experience

Surgical treatment of cardiac tumors - an overview and presentation of interesting cases

Tumors of the Heart and Great Vessels

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