Total Oxidant/Antioxidant Status in Sera of Patients with Esophageal Cancer

Huang, Qingmei; Feng, Jiafu; Wu, Rong; Yang, Yuwei; Dai, Chunmei; Li, Jie; Liao, Yixiang; Xiang, Miao; Wang, Dong; Du, Xiaobo

doi:10.12659/msm.902210

Cited by 14 publications

(14 citation statements)

References 27 publications

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“…The increase in the level of MDA and TOS in advanced group more than early group is perhaps due to excessive free radicals formation and lipid peroxidation occur due to the malignant interprets the utilization of existing antioxidant system for defending the additional oxidative stress. Huang et al (2017) measured serum TOS, TAS, and OSI in patients with esophageal cancer and healthy controls and were all significantly different, but they found no significant differences across different clinical stages in the cancer group.…”

Section: Discussionmentioning

confidence: 93%

Oxidative Stress Parameters in Patients with Breast Cancer before and after Radiotherapy

Youssef

Salem

2019

Egypt. J. Rad.Sci.

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R EACTIVE oxygen species (ROS) are generated in response to endogenous or exogenous stimuli. Antioxidants defense system resists for balancing ROS-mediated injury; if oxidation exceeds the defense mechanisms, oxidative stress is generated. Oxidative stress may be involved in the development of breast cancer. Moreover, radiationtherapy (RT), used for the treatment of breast cancer, works by the production of reactive oxygen species at the site of radiation which leads to local oxidative stress. Studies which detect one or few oxidant and antioxidant markers failed to detect the overall oxidant/antioxidant status of the subjects. The authors aim at studying the impact of radiotherapy on the total oxidant status (TOS), total antioxidant status (TAS) with calculation of oxidative stress index (OSI), and measure the lipid peroxidation (MDA) in breast cancer patients. TAS, TOS, MDA and OSI in healthy and breast cancer groups are measured. In breast cancer group, all parameters were measuredbefore and after radiation therapy. In the breast cancer group, TOS, OSI and MDA levels have increased significantly (P<0.001) and the TAS level has decreased (P<0.001) in the breast cancer patients after radiotherapy than before radiotherapy. Breast cancer group TAS after RT reaches about forth its level measured inthe control group. Radiotherapy in breast cancer patients depletes the total antioxidants (TAS), increases total oxidative status (TOS), lipid peroxidation (MDA) and OSI. Breast cancer and its treatment modalities display the patients in a state of severe oxidative stress which requires the supplementation of antioxidants.

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Section: Discussionmentioning

confidence: 93%

Oxidative Stress Parameters in Patients with Breast Cancer before and after Radiotherapy

Youssef

Salem

2019

Egypt. J. Rad.Sci.

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“…[18] Furthermore, the relationship between different malignancies with TOS and TAC levels was investigated in a great number of studies. [19][20][21] TOS and OSI index were found higher in esophageal cancer patients compared to controls. [21] Moreover, these biomarkers were reported to be candidates in the diagnosis of esophageal cancer.…”

Section: Discussionmentioning

confidence: 75%

“…[19][20][21] TOS and OSI index were found higher in esophageal cancer patients compared to controls. [21] Moreover, these biomarkers were reported to be candidates in the diagnosis of esophageal cancer. [21] On the other hand, authors demonstrated no correlation between stage of cancer and TOS levels.…”

Section: Discussionmentioning

confidence: 75%

“…[21] On the other hand, authors demonstrated no correlation between stage of cancer and TOS levels. [21] This correlation was shown in breast cancer patients; the TOS and the TAC levels were presented as prognostic biomarkers in breast cancer. [19] In the current research, we found a correlation between stage and oxidative stress status in contrast with the other study related to esophageal cancer.…”

Section: Discussionmentioning

confidence: 97%

“…[21] Moreover, these biomarkers were reported to be candidates in the diagnosis of esophageal cancer. [21] On the other hand, authors demonstrated no correlation between stage of cancer and TOS levels. [21] This correlation was shown in breast cancer patients; the TOS and the TAC levels were presented as prognostic biomarkers in breast cancer.…”

Section: Discussionmentioning

confidence: 99%

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Serum prolidase activity, total oxidant/antioxidant, and nitric oxide levels in patients with esophageal squamous cell carcinoma

Sayır

Şehitoğulları

Demır

et al. 2019

Turk Gogus Kalp Dama

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Bu çalışmada özofagusun skuamöz hücreli karsinomu olan hastalarda prolidaz aktivitesi, nitrik oksit düzeyleri ve oksidatif durum değerlendirildi.Ça lış ma pla nı: Çalışmaya özofagusun skuamöz hücreli karsinomu olan 30 hasta (11 erkek, 19 kadın; ort. yaş 61±3 yıl; dağılım, 28-77 yıl) ve 30 sağlıklı kontrol (10 erkek, 20 kadın; ort. yaş 58±5 yıl; dağılım, 31-73 yıl) dahil edildi. Serum prolidaz aktivitesi, total antioksidan kapasitesi, total oksidan durumu ve nitrik oksit düzeyleri ölçüldü. Ayrıca, oksidatif stres indeksi hesaplandı. Bul gu lar:Hasta grubunda belirgin şekilde artmış serum prolidaz aktivitesi, oksidatif stres indeksi değerleri, total oksidan durumu ve nitrik oksit düzeyleri saptandı (p<0.05). Hasta grubunda daha düşük total antioksidan kapasitesi düzeyleri gözlendi (p<0.05).So nuç:Özofagusun skuamöz hücreli karsinomu olan hastalarda artmış nitrik oksit düzeyleri ve prolidaz aktivitesi ile artmış oksidan durumu bulundu. Artmış prolidaz aktivitesi ve nitrik oksit düzeyleri ile antioksidan mekanizma bozukluğu, özofagusun skuamöz hücreli karsinomunun etyopatogenezinde önemli rol oynayabilir.Anah tar söz cük ler: Özofagus kanseri, nitrik oksit, prolidaz, total antioksidan kapasitesi, total oksidan durumu.

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Protective effects of rosmarinic acid against azoxymethane‐induced colorectal cancer in rats

İlhan

Bektaş

Susam

et al. 2021

J Biochem & Molecular Tox

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Colorectal cancer (CRC) incidence is increasing gradually and has been become one of the most common cancers worldwide. Hence, it is important to discover cheap, naturally occurring compounds to be effective in suppressing the devastating effect of colonrelated tumors. Rosmarinic acid (RA), one of the compounds of plant origin, possesses attractive features for use as an agent for cancer prevention and treatment. This study investigated the ability of RA to prevent azoxymethane (AOM)-induced rat colon carcinogenesis by evaluating the effect of RA on tumor formation and circulatory oxidantantioxidant status. Moreover, plasma levels of adiponectin (APN) monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6) were detected by enzyme linked immunosorbent assay. The animals were divided into three groups: Control, AOM, and AOM + RA. Rats were fed a modified pellet diet (15.8% peanut oil was added to the standard diet) during the experimental period. Colon cancer was formed by applying 15 mg/kg AOM intraperitoneal once a week for 4 weeks in both the CRC group and AOM + RA group. Besides AOM, AOM + RA group received 5 mg/kg body weight RA orally every day during the study. The results showed that adenocarcinoma rates formed 87.5% of the AOM group. With treatment of RA, a reduction in the incidence of adenocarcinoma was observed in the AOM + RA group. The plasma MCP-1, IL-6, and TO levels were significantly higher, APN and TAS levels were significantly lower in the AOM group with respect to controls. In addition, there was a significant increase in TAS levels in the RA treatment group compared to the AOM group. These findings suggested that RA may be beneficial in preventing AOM-induced colon carcinogenesis formation.

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Total Oxidant/Antioxidant Status in Sera of Patients with Esophageal Cancer

Cited by 14 publications

References 27 publications

Oxidative Stress Parameters in Patients with Breast Cancer before and after Radiotherapy

Oxidative Stress Parameters in Patients with Breast Cancer before and after Radiotherapy

Serum prolidase activity, total oxidant/antioxidant, and nitric oxide levels in patients with esophageal squamous cell carcinoma

Protective effects of rosmarinic acid against azoxymethane‐induced colorectal cancer in rats

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