Total protein in gingival crevicular fluid as indicators of periodontal disease activity: A clinico biochemical analysis

Koregol, Arati C; More, Shobha P; Koregol, Savita; Kalburgi, Nagaraj B

doi:10.4103/2394-2002.148885

Cited by 7 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In present study, we noticed elevated levels of total protein in periodontitis subjects, this increase in concentration may be attributed to modulation by extent of plasma protein exudation. Present study was in accordance with study conducted by Amita Ahire et al, Arati et al, Swati et al and Nada et al [14][15][16][17] Elevated levels of ROS levels were noted in the saliva of chronic periodontitis subjects. These elevated levels of ROS in saliva can result in imbalance between oxidants and antioxidants causing destruction of the periodontium leading to periodontitis.…”

Section: Discussionsupporting

confidence: 92%

Estimation of salivary glycoconjugates and salivary ros levels in chronic periodontitis: a clinico-biochemical study

Roy¹,

Manjunath²,

Bhat³

et al. 2017

Int J Res Med Sci

View full text Add to dashboard Cite

Background: Periodontitis is a chronic inflammatory disease of periodontal tissue, characterized by persistent inflammation of the connective tissue and alveolar bone destruction. Patients with periodontal disease show the differences in the composition of saliva. Newer diagnostic tools based on analysis of body fluids such as saliva, GCF and serum are found to be useful for diagnosis as well as monitoring the disease activity. Thus, aim of the study was to estimate the concentration of salivary glycoconjugates (sialic acid, total protein) and salivary ROS in unstimulated whole saliva of subjects with chronic periodontitis and to compare the concentration with healthy/gingivitis subjects.Methods: The study sample consisted of 60 subjects (33 males and 27 females) with age ranging from 30-60 years. A detailed case history was taken from all the subjects and periodontal disease parameters (bleeding on probing, probing pocket depth and clinical attachment levels) were recorded at baseline and subjects were divided into 2 groups. Group I- control group (healthy/gingivitis subjects) and Group II -test group (chronic periodontitis). Saliva samples were collected from the subjects and stored at -700 ºC. Periodate Resorcinol Assay was done to estimate the levels of sialic acid, Biuret test was done to assess the levels of total protein and d-ROMs test was done to assess the level of ROS. Statistical analysis was done using students unpaired ‘t’ test and Pearsons correlation test. Results: It was found that the levels of salivary glycoconjugates and ROS are increased in subjects with chronic periodontitis when compared to healthy/gingivitis subjects. Thus it can reflect the clinical status of gingival and periodontal tissues.Conclusions: Estimation of the levels of glycoconjugates and ROS may be used as one of the reliable biomarkers to assess the severity of periodontal disease and to monitor the disease progression.

show abstract

Section: Discussionsupporting

confidence: 92%

Estimation of salivary glycoconjugates and salivary ros levels in chronic periodontitis: a clinico-biochemical study

Roy¹,

Manjunath²,

Bhat³

et al. 2017

Int J Res Med Sci

View full text Add to dashboard Cite

show abstract

“…Chamazulene, another MTC constituent, has been shown to substantially protect against lipid peroxidation [24]. These observations are consistent with other researchers' findings, on the effects of matrica mouthwash on bacterial plaque and gingival inflammation, which found that this mouthwash has a major impact on plaque accumulation, bleeding on probing, and gingival inflammation [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25].In the treatment of chronic gingivitis, a related process could be found in the effect of 0.12 % CHX mouthwash after scaling and polishing, leading to a reduction in clinical periodontal parameters such as PI, GI, and BOP compared to scaling and polishing alone [26]. The decline may be due to CHX mouthwash's positive effect on plaque formation by its antibacterial activity, which greatly decreases and controls gingival inflammation in patients with poor oral hygiene [27].The results showed no significant difference in the mean values of gingival indices between the chlorhexidine and chamomile as mouthwashes [19].…”

Section: Discussionsupporting

confidence: 87%

“…As a result, 1 kilogram of concentrated liquid extract (chamomile mouthwash) was produced. Concentration of 1% is obtained by dilute 1 mL of mouthwash in 100 mL of pre-boiled water [11][12][13][14][15][16][17][18][19].…”

Section: Chamomile Mouth Washing Preparationmentioning

confidence: 99%

“…It may be used in gingivitis and periodontitis as a possible biochemical marker to evaluate the activities of periodontal disease [13].Alkaline phosphatase (ALP) is a biochemical marker that has the special property of being implicated in periodontal inflammation, also, Dilyar Ahmed Baban Efficacy of Chamomile Mouthwash on Clinical And Serum Inflammatory Parameters in Relation to Chlorhexidine in Chronic Gingivitis Patients it is an essential biochemical marker that is characterized by its participation in periodontal inflammation [14].Total protein (TP) can be used as a potential biochemical marker for assessing periodontal disease occurrence in gingivitis and periodontitis. It can be used as a potential diagnostic marker of active disease status in periodontal tissues and to estimate successful prevention and treatment strategies [15].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of Chamomile Mouthwash on Clinical And Serum Inflammatory Parameters in Relation to Chlorhexidine in Chronic Gingivitis Patients

Baban¹

2021

DJM

View full text Add to dashboard Cite

Background: Oral and systemic infections are closely linked to poor oral hygiene. Chlorhexidine mouthwash, in addition to tooth brushing has been commonly recommended. About the fact that there is a lot of studies on the effectiveness of chamomile as an herbal mouthwash, there isn't much evidence on its competitive effect with chlorhexidine. Objective: To determine the clinical and inflammatory effects of chamomile as mouthwash (MTC) in the treatment of chronic gingivitis and compare its effect with 0.12% chlorhexidine (CHX). Patients and Methods: A total of 45 subjects aged 18-45 years with chronic gingivitis underwent scaling and polishing with oral hygiene instruction; 15 patients received 1% of (MTC) as mouthwash, 15 patients received 0.12% of chlorhexidine mouthwash, and 15 patients received scaling and polishing only (SRP). Mouthwash was twice daily for 14 days. At the start of the study, clinical periodontal parameters (PI, GI, and BOP) and blood samples were taken and after four weeks of treatment to estimate the levels of C-reactive protein (CRP), alkaline phosphatase (ALP) and total protein (TP). Results: After 4 weeks of periodontal treatment, there was a significant decrease in clinical periodontal parameters (P<0.01) and inflammatory markers (P<0.05) in the MTC and CHX and S&P alone groups. From periodontal treatment, there was no significant difference between the MTC and CHX groups with clinical periodontal parameters and inflammatory markers (P<0.05), although there was a significant difference between the MTC, CHX groups, and the S&P alone group in terms of clinical periodontal parameters and inflammatory markers (P<0.05). Conclusion: Chamomile has been shown to be comparable to CHX in terms of reducing gingivitis by decreasing clinical periodontal parameters and inflammatory chemical markers values such as CRP, ALP, and TP. Keywords: Chamomile; mouthwash; chlorhexidine; gingivitis, CRP, ALP, TP, serum

show abstract

“…Total protein (TP) used as a potential biochemical marker for determining periodontal disease occurrence in gingivitis and periodontitis. It is used as a potential diagnostic biomarker for active disease status in periodontal tissues and to determine successful treatment and prevention strategies [15].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Olive Leaf Extract Mouthwash on Clinical and Inflammatory Parameters of Gingival Inflammation in Relation to Chlorhexidine in Acute Gingivitis Serum Patients

Hasan¹,

Latif²,

Mohammed³

2022

DJM

View full text Add to dashboard Cite

Background: Oral and gum infections are mostly linked to poor oral hygiene. Chlorhexidine mouthwash, and teeth brushing, have been commonly recommended. There is many studies on the effectiveness of olive leaf extract (OLE) as herbal mouthwash, there is much guided on its competitive effect with chlorhexidine.Objective: To determine the clinical and inflammatory effects of olive leaf extract (OLE) as mouthwash in the treatment of acute gingivitis and compare its effect with 0.12% chlorhexidine mouthwash (CHX).Patients and Methods: A total of 60 subjects aged 18-35 years with acute gingivitis underwent scaling and polishing with oral hygiene instruction; 20 patients received 3% of (OLE) as mouthwash, 20 patients received of 0.12% of chlorhexidine mouthwash (CHX), and 20 patients received scaling and polishing only (SRP) without any mouthwash. Mouthwash was twice daily for 17 days. At the start of the study, clinical periodontal parameters (PI, GI and BOP) and blood samples were taken and after five weeks of treatment to estimate the levels of C-reactive protein (CRP), alkaline phosphatase (ALP) and total protein (TP). Results: After 5 weeks of periodontal treatment, there was a significant decrease in clinical periodontal parameters (P<0.01) and inflammatory markers (P<0.05) in the OLE and CHX and S&P alone groups. From periodontal treatment, there was no significant difference between the OLE and CHX groups with clinical periodontal parameters and inflammatory markers (P<0.05), although there was a significant difference between the OLE, CHX groups and the S&P alone group in terms of clinical periodontal parameters and inflammatory markers (P<0.05). Conclusion: Olive leaf extract (OLE) has been showed to be comparable to CHX aided in reducing gingivitis by decreasing clinical periodontal parameters and inflammatory chemical markers values such as CRP, ALP, and TP. Keywords: olive leaf extract (OLE, mouthwash, chlorhexidine, gingivitis, CRP, ALP, TP

show abstract

Total protein in gingival crevicular fluid as indicators of periodontal disease activity: A clinico biochemical analysis

Cited by 7 publications

References 0 publications

Estimation of salivary glycoconjugates and salivary ros levels in chronic periodontitis: a clinico-biochemical study

Estimation of salivary glycoconjugates and salivary ros levels in chronic periodontitis: a clinico-biochemical study

Efficacy of Chamomile Mouthwash on Clinical And Serum Inflammatory Parameters in Relation to Chlorhexidine in Chronic Gingivitis Patients

Efficacy of Olive Leaf Extract Mouthwash on Clinical and Inflammatory Parameters of Gingival Inflammation in Relation to Chlorhexidine in Acute Gingivitis Serum Patients

Contact Info

Product

Resources

About