Total serum immunoglobulin E as a marker for missed antigens on in vitro allergy screening

Hatcher, Jeanne L.; Cohen, Samuel D.; Mims, James W.

doi:10.1002/alr.21207

Cited by 9 publications

(5 citation statements)

References 15 publications

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“…In vitro testing (27) : a) Serum total IgE (tIgE) There is some disagreement over the role of serum tIgE in the diagnosis of atopic disorders. The capacity of the tIgE serum level to identify patients with atopy in general may be what makes it so significant.…”

Section: Intradermal Skin Test (Idst)mentioning

confidence: 99%

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Assessment of Allergic Rhinitis from Medical Microbiology Background: Review Article

Rashad¹,

Bahgat²,

Ali³

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: Sneezing, postnasal drip, nasal pruritis, and nasal congestion are all signs of allergic rhinitis (AR), an atopic condition. It affects one in six people and is linked to high morbidity, severe productivity loss, and high healthcare expenses. In the past, AR was believed to be a nasal airway-specific disease. However, the emergence of the unified airway hypothesis has identified the atopic dermatitis (AD) and other related disorders, such as asthma, as components of systemic allergic reaction.Objective: Review of literature about assessment of Allergic Rhinitis from Medical Microbiology Background Methods: We searched PubMed, Google Scholar, and Science Direct for relevant articles on allergic rhinitis and medical microbiology background. However, only the most recent or thorough studies were taken into account between February 2001 and May 2023. The authors also evaluated the value of resources culled from other works in the same genre. Therefore, documents written in languages other than English have been ignored due to a lack of translation funds. Unpublished works, oral presentations, conference abstracts, and dissertations were generally agreed upon not to qualify as scientific research. Conclusion: Due to changes in the immune system, AR is an IgE-mediated illness that develops in genetically vulnerable people after exposure to environmental allergens. The majority of the common allergens linked to AR are proteins and glycoproteins present in airborne particles. As a result of the inhalation of allergen particles, the nasal epithelium becomes coated, allowing soluble allergenic proteins to elute and diffuse into the nasal mucosa. Numerous aeroallergens enhance allergen entry to antigen presentating cells (APCs) during the early sensitization process. In AR tight junctions in the airway epithelium are cleaved and epithelial cells are activated thanks to the protease activities of these proteins. Skin prick testing is used to confirm an AR diagnosis alongside a patient's history and a physical exam.

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Section: Intradermal Skin Test (Idst)mentioning

confidence: 99%

“…In AR patients, a serum tIgE level more than 140 IU/mL may be indicative of atopy. In the absence of a positive inhalant-specific IgE test, a high tIgE may indicate inhalant sensitivity to unknown allergens or another kind of chronic respiratory inflammatory illness other than AR (27) .…”

Section: Intradermal Skin Test (Idst)mentioning

confidence: 99%

Assessment of Allergic Rhinitis from Medical Microbiology Background: Review Article

Rashad¹,

Bahgat²,

Ali³

et al. 2023

The Egyptian Journal of Hospital Medicine

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“…19,20 Başka bir çalışmada da, in vitro allerjen testi ile gözden kaçan antijen duyarlılığını değerlendirmede serum total IgE dü-zeyinin kullanılması önerilmiştir. 21 Astım ve allerjik rinitte IgE yüksekliği klinisyeni allerjen duyarlılığını incelemeye yönlendirmelidir.…”

Section: İmmünglobuli̇n E Yüksekli̇ği̇nde Ayirici Taniunclassified

Clinical Significance of Elevated Serum Total IgE: Review

Yılmaz¹

2015

Turkiye Klinikleri J Pediatr

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“…The vast majority of asthmatics display higher total serum IgE. Consequently, including a broader panel of allergens in the testing reveals more cases of "allergic asthma" (extrinsic asthma) among asthmatics (6). So far, many patients with asthma lack proper allergy diagnosis due to the fact that in vitro routine allergy diagnostic tests are missing clinically relevant allergen sources, and where allergen sources are included as raw extract allergens, these often lack clinically relevant single allergenic components and, therefore, appropriate sensitivity.…”

Section: Introductionmentioning

confidence: 99%

IgE Epitope Profiling for Allergy Diagnosis and Therapy – Parallel Analysis of a Multitude of Potential Linear Epitopes Using a High Throughput Screening Platform

et al. 2020

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Krause et al. OBOC-Library Screening With IgE library by using IgE directed against those test-peptides at physiological concentrations (≤20 IU/ml of specific IgE), and disease-relevant bead-bound epitopes of the major peanut allergen Ara h 2 by screening with sera from peanut allergics. Thus, we established a platform with which one can find and validate new immunoglobulin targets using patient material which displays a largely unknown immunoglobulin repertoire.

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Total serum immunoglobulin E as a marker for missed antigens on in vitro allergy screening

Cited by 9 publications

References 15 publications

Assessment of Allergic Rhinitis from Medical Microbiology Background: Review Article

Assessment of Allergic Rhinitis from Medical Microbiology Background: Review Article

Clinical Significance of Elevated Serum Total IgE: Review

IgE Epitope Profiling for Allergy Diagnosis and Therapy – Parallel Analysis of a Multitude of Potential Linear Epitopes Using a High Throughput Screening Platform

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