Total synthesis of pleosporol A and its stereoisomers

Marine natural products

“…271 A homodimeric bispyrrolidinoindoline dioxopiperazine alkaloid isolated from sponge-derived Aspergillus violaceofuscus has been prepared, 272 and synthesis of chlorinated alkaloids gymnastatin G and dankastatins B and C has also been achieved. 273 Cyclohexenone derivative pleosporol A (and its stereoisomers) has been prepared from arabinose, 274 peniciaculins A and B and hydroxysydonic acid have been synthesised via an enantioselective method, 275 as have (+)-peniciketals A and B, 276,277 and (−)-spiroxin D. 278 In silico prediction of SARS-CoV-2 main protease binding ability for marine fungal compounds predicted wailupemycins H and I, and cottoquinazoline B to have high nanomolar inhibition for preventing viral replication, 279 and another in silico study indicated that epolactaene would also inhibit this protease. 280 3-Bromoascochlorin suppressed small cell lung cancer growth in a xenogra mouse model without affecting body weight.…”

“…271 A homodimeric bispyrrolidinoindoline dioxopiperazine alkaloid isolated from sponge-derived Aspergillus violaceofuscus has been prepared, 272 and synthesis of chlorinated alkaloids gymnastatin G and dankastatins B and C has also been achieved. 273 Cyclohexenone derivative pleosporol A (and its stereoisomers) has been prepared from arabinose, 274 peniciaculins A and B and hydroxysydonic acid have been synthesised via an enantioselective method, 275 as have (+)-peniciketals A and B, 276,277 and (−)-spiroxin D. 278…”