Totally biodegradable poly(trimethylene carbonate/glycolide-block-L-lactide/glycolide) copolymers: synthesis, characterization and enzyme-catalyzed degradation behavior

Wu, Ye; Chen, Xiaoyu; Fan, Zhongyong

doi:10.1016/j.eurpolymj.2018.02.028

Cited by 16 publications

(13 citation statements)

References 50 publications

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“…However, PTG‐ b ‐LG showed a significant variation of degree of

\overset{M_{n}}{false}

reduction as compared with PT‐ b ‐LG in the final stage of the degradation process. It is well understood that PTG‐ b ‐LG possesses the Di ‐random block structures, and the regularity of the chain is lower, thus water diffuses into amorphous regions easily . PDI was obtained to further assess the change of

\overset{M_{n}}{false}

during the degradation process.…”

Section: Resultssupporting

confidence: 93%

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Effect of segment structures on the hydrolytic degradation behaviors of totally degradable poly(L‐lactic acid)‐based copolymers

Fan

et al. 2019

J of Applied Polymer Sci

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A series of high‐molecular‐weight terpolymers named PTG‐b‐LG and PT‐b‐LG were synthesized based on the macroinitiators of PTG copolymers and PTMC, respectively. In vitro degradation of PTG‐b‐LG and PT‐b‐LG was carried out by immersing into PBS, in comparison with that of PLLA. Mass loss, water uptake, GPC, DSC, WAXD, and 1H NMR were examined for the degradation study. It was found that PTG‐b‐LG degraded faster than PT‐b‐LG and PLLA due to the Di‐random block structure, which had lower regularity of chain and lower crystallinity. The compositional changes appeared to be more complex, but the molar mass decreased owing to chain fragmentation caused by hydrolysis. Moreover, morphological changes were also observed during the degradation in all situations with the crystallization of by‐products and a preferential degradation of amorphous domains. Specifically, PTG‐b‐LG presented an adjustable degradation rate and may be used for the fabrication of totally biodegradation stents in the future. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47887.

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“…However, PTG‐ b ‐LG showed a significant variation of degree of

\overset{M_{n}}{false}

\overset{M_{n}}{false}

during the degradation process.…”

Section: Resultssupporting

confidence: 93%

“…Compared with PLLA, introducing PTMC into PLLA segments enhances the toughness of copolymers . and degrades quickly through an enzymatic surface erosion degradation mechanism . Noticeably, copolymerization of PLGA with PTMC, and even TMC‐ co ‐GA is an effective approach to reduce the stiffness of the polymers …”

Section: Introductionmentioning

confidence: 99%

Effect of segment structures on the hydrolytic degradation behaviors of totally degradable poly(L‐lactic acid)‐based copolymers

Fan

et al. 2019

J of Applied Polymer Sci

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“…This finding could be assigned to the loss of TMC components together with the degradation of LA moieties, even PTMC itself does not degrade in phosphate-buffered saline without enzyme. Similar findings have also been reported in the case of other polylactide copolymers [22,31] Figure 5 shows the DSC curves of the first and the second scans of lcP(TMC-b-LLA)74 at different degradation times. The thermal property changes of linear-comb PLLA/PTMC copolymers are summarized in Table 3.…”

Section: Molecular Weight and Composition Evolutionsupporting

confidence: 84%

Hydrolytic Degradation of Comb-Like Graft Poly (Lactide-co-Trimethylene Carbonate): The Role of Comonomer Compositions and Sequences

et al. 2019

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The effect of sequence on copolymer properties is rarely studied, especially the degradation behavior of the biomaterials. A series of linear-comb block, gradient, random copolymers were successfully achieved using hydroxylated polybutadiene as the macroinitiator by simple ring-opening polymerization of l-lactide (l-LA) and 1,3-trimethylene carbonate (TMC). The hydrolytic degradation behaviors of the copolymers were systemically evaluated by using nuclear magnetic resonance (NMR), gel permeation chromatography (GPC), differential scanning calorimeter (DSC), and scanning electron microscopy (SEM) to illustrate the influences of comonomer compositions and sequence structures. The linear-comb block copolymers (lcP(TMC-b-LLA)) with different compositions had different degradation rates, which increased with l-LA content. Thermal property changes were observed with decreased Tm and increased ΔHm in all block copolymers during the degradation. To combine different sequence structures, unique degradation behaviors were observed for the linear-comb block, gradient and random copolymers even with similar comonomer composition. The degradation rates of linear-comb PLLA-gradient-PTMC (lcP(LLA-grad-TMC)) and linear-comb PLLA-random-PTMC (lcP(LLA-ran-TMC)) were accelerated due to the loss of regularity and crystallinity, resulting in a remarkable decrease on weight retention and molar mass. The hydrolysis degradation rate increased in the order lcP(TMC-b-LLA), lcP(LLA-ran-TMC), lcP(LLA-grad-TMC). Therefore, the hydrolytic degradation behavior of comb-like graft copolymers depends on both the compositions and the sequences dramatically.

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“…53 PLGA-PTMC-PLGA block terpolymers have also been explored. 54 Smola et al synthesized these using branched PTMC macroinitiators of various M n s. Branching was introduced into the PTMC macrodiols by using initiators with varying amounts of hydroxyl groups to synthesize them. Using glycerol or pentaerythritol as initiators created cross-linked PTMC oligomers, which, when used as macroinitiators, introduced small amounts of cross-linking into the terpolymer, improving the mechanical properties.…”

Section: Plgt -(Poly(lactic Acid-glycolic Acid-co-trimethylene Carbonate)mentioning

confidence: 99%

Poly(glycolic acid) (PGA): a versatile building block expanding high performance and sustainable bioplastic applications

et al. 2020

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Totally biodegradable poly(trimethylene carbonate/glycolide-block-L-lactide/glycolide) copolymers: synthesis, characterization and enzyme-catalyzed degradation behavior

Cited by 16 publications

References 50 publications

Effect of segment structures on the hydrolytic degradation behaviors of totally degradable poly(L‐lactic acid)‐based copolymers

Effect of segment structures on the hydrolytic degradation behaviors of totally degradable poly(L‐lactic acid)‐based copolymers

Hydrolytic Degradation of Comb-Like Graft Poly (Lactide-co-Trimethylene Carbonate): The Role of Comonomer Compositions and Sequences

Poly(glycolic acid) (PGA): a versatile building block expanding high performance and sustainable bioplastic applications

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